Tailorable Piezoelectric Chain Morphology in Biocompatible Poly-l-lactide Induced by Melt-Based 3D Printing

Biobased and biodegradable poly-l-lactide (PLLA) stands out among piezoelectric polymers for its biocompatibility and environmental sustainability. Its piezoelectric response is closely related to the crystallinity and the alignment of polymer chains, which is conventionally obtained by drawing tech...

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Autores: Pascual-González, Cristina, Pacheco-Carpio, Gustavo, Fernandez-Blazquez, J.P., Serrano, María C., Wicklein, Bernd, Algueró, Miguel, Amorín, Harvey
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/413779
Acceso en línea:http://hdl.handle.net/10261/413779
https://www.scopus.com/inward/record.uri?eid=2-s2.0-105004375325&doi=10.1021%2Facsapm.5c00450&partnerID=40&md5=c86fe7e0bead145ad9c0859c64ba0e08
Access Level:acceso abierto
Palabra clave:Crystallinity
Fused deposition modeling
Piezoelectricity
Poly-l-lactide
Polymer orientation
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dc.title.none.fl_str_mv Tailorable Piezoelectric Chain Morphology in Biocompatible Poly-l-lactide Induced by Melt-Based 3D Printing
title Tailorable Piezoelectric Chain Morphology in Biocompatible Poly-l-lactide Induced by Melt-Based 3D Printing
spellingShingle Tailorable Piezoelectric Chain Morphology in Biocompatible Poly-l-lactide Induced by Melt-Based 3D Printing
Pascual-González, Cristina
Crystallinity
Fused deposition modeling
Piezoelectricity
Poly-l-lactide
Polymer orientation
title_short Tailorable Piezoelectric Chain Morphology in Biocompatible Poly-l-lactide Induced by Melt-Based 3D Printing
title_full Tailorable Piezoelectric Chain Morphology in Biocompatible Poly-l-lactide Induced by Melt-Based 3D Printing
title_fullStr Tailorable Piezoelectric Chain Morphology in Biocompatible Poly-l-lactide Induced by Melt-Based 3D Printing
title_full_unstemmed Tailorable Piezoelectric Chain Morphology in Biocompatible Poly-l-lactide Induced by Melt-Based 3D Printing
title_sort Tailorable Piezoelectric Chain Morphology in Biocompatible Poly-l-lactide Induced by Melt-Based 3D Printing
dc.creator.none.fl_str_mv Pascual-González, Cristina
Pacheco-Carpio, Gustavo
Fernandez-Blazquez, J.P.
Serrano, María C.
Wicklein, Bernd
Algueró, Miguel
Amorín, Harvey
author Pascual-González, Cristina
author_facet Pascual-González, Cristina
Pacheco-Carpio, Gustavo
Fernandez-Blazquez, J.P.
Serrano, María C.
Wicklein, Bernd
Algueró, Miguel
Amorín, Harvey
author_role author
author2 Pacheco-Carpio, Gustavo
Fernandez-Blazquez, J.P.
Serrano, María C.
Wicklein, Bernd
Algueró, Miguel
Amorín, Harvey
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Comunidad de Madrid
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Crystallinity
Fused deposition modeling
Piezoelectricity
Poly-l-lactide
Polymer orientation
topic Crystallinity
Fused deposition modeling
Piezoelectricity
Poly-l-lactide
Polymer orientation
description Biobased and biodegradable poly-l-lactide (PLLA) stands out among piezoelectric polymers for its biocompatibility and environmental sustainability. Its piezoelectric response is closely related to the crystallinity and the alignment of polymer chains, which is conventionally obtained by drawing techniques. These are two-step processes with tight shape constraints, and the material technology implementation would strongly benefit from the demonstration of a single-step process capable of directly achieving tailored piezoelectric morphology in PLLA biopolymer from polymer melt. Fused deposition modeling (FDM) three-dimensional (3D) printing can play this role, directly achieving tailored piezoelectric morphology in PLLA biopolymer by the microscale control of molecular chain orientation through preparation parameters, such as 3D printing speed or bed temperature. The printing-crystal phase content and texture-piezoelectric property relationships are comprehensively presented, and the key 3D printing parameters to obtain optimized piezoelectric chain morphologies are defined. Results reveal melt-based 3D printing to be a suitable technique for manufacturing biocompatible PLLA piezoelectric platforms that are also biodegradable. A commercial PLLA (molecular weight of 160 kDa) has been used, with which a large shear piezoelectric coefficient (d<inf>14</inf> = 8.5 pC/N) was attained after optimized printing. Biocompatibility in vitro with murine L929 fibroblasts is confirmed for this specific material, opening its use not only for smart monitoring but also for biomedical applications, including tissue engineering. © 2025 Elsevier B.V., All rights reserved.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
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Publisher's version
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dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/413779
https://www.scopus.com/inward/record.uri?eid=2-s2.0-105004375325&doi=10.1021%2Facsapm.5c00450&partnerID=40&md5=c86fe7e0bead145ad9c0859c64ba0e08
url http://hdl.handle.net/10261/413779
https://www.scopus.com/inward/record.uri?eid=2-s2.0-105004375325&doi=10.1021%2Facsapm.5c00450&partnerID=40&md5=c86fe7e0bead145ad9c0859c64ba0e08
dc.language.none.fl_str_mv Inglés
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dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
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spelling Tailorable Piezoelectric Chain Morphology in Biocompatible Poly-l-lactide Induced by Melt-Based 3D PrintingPascual-González, CristinaPacheco-Carpio, GustavoFernandez-Blazquez, J.P.Serrano, María C.Wicklein, BerndAlgueró, MiguelAmorín, HarveyCrystallinityFused deposition modelingPiezoelectricityPoly-l-lactidePolymer orientationBiobased and biodegradable poly-l-lactide (PLLA) stands out among piezoelectric polymers for its biocompatibility and environmental sustainability. Its piezoelectric response is closely related to the crystallinity and the alignment of polymer chains, which is conventionally obtained by drawing techniques. These are two-step processes with tight shape constraints, and the material technology implementation would strongly benefit from the demonstration of a single-step process capable of directly achieving tailored piezoelectric morphology in PLLA biopolymer from polymer melt. Fused deposition modeling (FDM) three-dimensional (3D) printing can play this role, directly achieving tailored piezoelectric morphology in PLLA biopolymer by the microscale control of molecular chain orientation through preparation parameters, such as 3D printing speed or bed temperature. The printing-crystal phase content and texture-piezoelectric property relationships are comprehensively presented, and the key 3D printing parameters to obtain optimized piezoelectric chain morphologies are defined. Results reveal melt-based 3D printing to be a suitable technique for manufacturing biocompatible PLLA piezoelectric platforms that are also biodegradable. A commercial PLLA (molecular weight of 160 kDa) has been used, with which a large shear piezoelectric coefficient (d<inf>14</inf> = 8.5 pC/N) was attained after optimized printing. Biocompatibility in vitro with murine L929 fibroblasts is confirmed for this specific material, opening its use not only for smart monitoring but also for biomedical applications, including tissue engineering. © 2025 Elsevier B.V., All rights reserved.Research was funded by projects PID2023-152475OB-100, PID2021-122708OB-C33, CNS2023-144808, and TED2021-130871B–C21, funded by MCIN/AEI/10.13039/501100011033, and, as appropriate, by ERDF A way of making Europe by the “European Union” or by the “European Union NextGeneration EU/PRTR”. CPG and BW also acknowledge the support of Ramón y Cajal programme (grant RYC2021-034194-I, RYC2021-034164-I). Víctor Caz is acknowledged for assistance with biocompatibility studies. The Advanced Light Microscopy Service at the Centro Nacional de Biotecnología (CNB–CSIC) is acknowledged for assistance with confocal microscopy studies and the Scanning Electron Microscopy Service at the Instituto de Micro y Nanotecnología (IMN-CSIC) for FE-SEM. The MiNa Laboratory at IMN-CSIC acknowledges funding from CM (project S2018/NMT-4291 TEC2SPACE), MINECO (project CSIC13-4 × 10–1794), and EU (FEDER, FSE).Peer reviewedAmerican Chemical SocietyAgencia Estatal de Investigación (España)Comunidad de MadridConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202620262025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/413779https://www.scopus.com/inward/record.uri?eid=2-s2.0-105004375325&doi=10.1021%2Facsapm.5c00450&partnerID=40&md5=c86fe7e0bead145ad9c0859c64ba0e08reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2023-152475OB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2021-122708OB-C33CNS2023-144808info:eu-repo/grantAgreement/AEI//info:eu-repo/grantAgreement/AEI//info:eu-repo/grantAgreement/AEI//S2018/NMT-4291/TEC2SPACEACS Applied Polymer Materialshttps://doi.org/10.1021/acsapm.5c00450Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4137792026-05-22T06:33:51Z
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