Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium

Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here, the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium presents the largest-ever analysis of cerebral c...

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Autores: Kong, XZ, Mathias, SR, Guadalupe, T, Glahn, DC, Franke, B, Crivello, F, Tzourio-Mazoyer, N, Fisher, SE, Thompson, PM, Francks, C, Portella M.J., Orhan, Funda
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Recursos:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p6200
Acesso em linha:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6200
Access Level:acceso abierto
Palavra-chave:brain asymmetry
lateralization
cortical thickness
surface area
meta-analysis
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spelling Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA ConsortiumKong, XZMathias, SRGuadalupe, TGlahn, DCFranke, BCrivello, FTzourio-Mazoyer, NFisher, SEThompson, PMFrancks, CPortella M.J.Orhan, Fundabrain asymmetrylateralizationcortical thicknesssurface areameta-analysisHemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here, the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium presents the largest-ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric and regional levels, with a generally thicker cortex but smaller surface area in the left hemisphere relative to the right. Regionally, asymmetries of cortical thickness and/or surface area were found in the inferior frontal gyrus, transverse temporal gyrus, parahippocampal gyrus, and entorhinal cortex. These regions are involved in lateralized functions, including language and visuospatial processing. In addition to population-level asymmetries, variability in brain asymmetry was related to sex, age, and intracranial volume. Interestingly, we did not find significant associations between asymmetries and handedness. Finally, with two independent pedigree datasets (n = 1,443 and 1,113, respectively), we found several asymmetries showing significant, replicable heritability. The structural asymmetries identified and their variabilities and heritability provide a reference resource for future studies on the genetic basis of brain asymmetry and altered laterality in cognitive, neurological, and psychiatric disorders.NATL ACAD SCIENCES2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6200PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAISSN: 00278424ISSNe: 10916490reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p62002026-06-14T12:41:47Z
dc.title.none.fl_str_mv Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium
title Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium
spellingShingle Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium
Kong, XZ
brain asymmetry
lateralization
cortical thickness
surface area
meta-analysis
title_short Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium
title_full Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium
title_fullStr Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium
title_full_unstemmed Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium
title_sort Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium
dc.creator.none.fl_str_mv Kong, XZ
Mathias, SR
Guadalupe, T
Glahn, DC
Franke, B
Crivello, F
Tzourio-Mazoyer, N
Fisher, SE
Thompson, PM
Francks, C
Portella M.J.
Orhan, Funda
author Kong, XZ
author_facet Kong, XZ
Mathias, SR
Guadalupe, T
Glahn, DC
Franke, B
Crivello, F
Tzourio-Mazoyer, N
Fisher, SE
Thompson, PM
Francks, C
Portella M.J.
Orhan, Funda
author_role author
author2 Mathias, SR
Guadalupe, T
Glahn, DC
Franke, B
Crivello, F
Tzourio-Mazoyer, N
Fisher, SE
Thompson, PM
Francks, C
Portella M.J.
Orhan, Funda
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv brain asymmetry
lateralization
cortical thickness
surface area
meta-analysis
topic brain asymmetry
lateralization
cortical thickness
surface area
meta-analysis
description Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here, the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium presents the largest-ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric and regional levels, with a generally thicker cortex but smaller surface area in the left hemisphere relative to the right. Regionally, asymmetries of cortical thickness and/or surface area were found in the inferior frontal gyrus, transverse temporal gyrus, parahippocampal gyrus, and entorhinal cortex. These regions are involved in lateralized functions, including language and visuospatial processing. In addition to population-level asymmetries, variability in brain asymmetry was related to sex, age, and intracranial volume. Interestingly, we did not find significant associations between asymmetries and handedness. Finally, with two independent pedigree datasets (n = 1,443 and 1,113, respectively), we found several asymmetries showing significant, replicable heritability. The structural asymmetries identified and their variabilities and heritability provide a reference resource for future studies on the genetic basis of brain asymmetry and altered laterality in cognitive, neurological, and psychiatric disorders.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6200
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6200
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv NATL ACAD SCIENCES
publisher.none.fl_str_mv NATL ACAD SCIENCES
dc.source.none.fl_str_mv PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN: 00278424
ISSNe: 10916490
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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