Diet and lifestyle in relation to small intestinal cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)

Purpose The incidence of small intestinal cancer (SIC) is increasing, however, its aetiology remains unclear due to a lack of data from large-scale prospective cohorts. We examined modifiable risk factors in relation to SIC overall and by histological subtype. Methods We analysed 450,107 participant...

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Autores: Ersoy Guller, Zeynep Betul, Harewood, Rhea, Weiderpass, Elisabete, Huybrechts, Inge, Jenab, Mazda, Huerta, José María, Sánchez, María-José, Jakszyn, Paula, Amiano, Pilar, Ardanaz, Eva, Agnoli, Claudia, Tumino, Rosario, Palli, Domenico, Skeie, Guri, Manjer, Jonas, Papier, Keren, Tjønneland, Anne, Eriksen, Anne Kirstine, Schulze, Matthias B., Kaaks, Rudolf, Katzke, Verena Andrea, Bergmann, Manuela M., Riboli, Elio, Gunter, Marc J., Cross, Amanda J.
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.14342/5232
Acceso en línea:http://hdl.handle.net/20.500.14342/5232
https://doi.org/10.1007/s10552-023-01731-w
Access Level:acceso abierto
Palabra clave:Intestí prim -- Càncer
Adenocarcinoma
Carcinoide
Alimentació
Estil de vida
Alcohol
Hàbit de fumar
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spelling Diet and lifestyle in relation to small intestinal cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)Ersoy Guller, Zeynep BetulHarewood, RheaWeiderpass, ElisabeteHuybrechts, IngeJenab, MazdaHuerta, José MaríaSánchez, María-JoséJakszyn, PaulaAmiano, PilarArdanaz, EvaAgnoli, ClaudiaTumino, RosarioPalli, DomenicoSkeie, GuriManjer, JonasPapier, KerenTjønneland, AnneEriksen, Anne KirstineSchulze, Matthias B.Kaaks, RudolfKatzke, Verena AndreaBergmann, Manuela M.Riboli, ElioGunter, Marc J.Cross, Amanda J.Intestí prim -- CàncerAdenocarcinomaCarcinoideAlimentacióEstil de vidaAlcoholHàbit de fumarPurpose The incidence of small intestinal cancer (SIC) is increasing, however, its aetiology remains unclear due to a lack of data from large-scale prospective cohorts. We examined modifiable risk factors in relation to SIC overall and by histological subtype. Methods We analysed 450,107 participants enrolled in the European Prospective Investigation into Cancer and Nutrition cohort. Cox proportional hazards models were used to estimate univariable and multivariable hazard ratios (HRs) and 95% confidence intervals (CIs). Results During an average of 14.1 years of follow-up, 160 incident SICs (62 carcinoids, 51 adenocarcinomas) were identified. Whilst univariable models revealed a positive association for current versus never smokers and SIC (HR, 95% CI: 1.77, 1.21–2.60), this association attenuated in multivariable models. In energy-adjusted models, there was an inverse association across vegetable intake tertiles for SIC overall (HRT3vsT1, 95% CI: 0.48, 0.32–0.71, p-trend: < 0.001) and for carcinoids (HRT3vsT1, 95% CI: 0.44, 0.24–0.82, p-trend: 0.01); however, these attenuated in multivariable models. Total fat was also inversely associated with total SIC and both subtypes but only in the second tertile (SIC univariable HRT2vsT1, 95% CI: 0.57, 0.38–0.84; SIC multivariable HRT2vsT1, 95% CI: 0.55, 0.37–0.81). Physical activity, intake of alcohol, red or processed meat, dairy products, or fibre were not associated with SIC. Conclusion These exploratory analyses found limited evidence for a role of modifiable risk factors in SIC aetiology. However, sample size was limited, particularly for histologic subtypes; therefore, larger studies are needed to delineate these associations and robustly identify risk factors for SIC.info:eu-repo/semantics/publishedVersionSpringer NatureUniversitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna2023info:eu-repo/semantics/article11 p.http://hdl.handle.net/20.500.14342/5232https://doi.org/10.1007/s10552-023-01731-wreponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésCancer Causes and Control, 2023, 34: 927-937© L'autor/aAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.14342/52322026-05-29T05:05:01Z
dc.title.none.fl_str_mv Diet and lifestyle in relation to small intestinal cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)
title Diet and lifestyle in relation to small intestinal cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)
spellingShingle Diet and lifestyle in relation to small intestinal cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)
Ersoy Guller, Zeynep Betul
Intestí prim -- Càncer
Adenocarcinoma
Carcinoide
Alimentació
Estil de vida
Alcohol
Hàbit de fumar
title_short Diet and lifestyle in relation to small intestinal cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)
title_full Diet and lifestyle in relation to small intestinal cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)
title_fullStr Diet and lifestyle in relation to small intestinal cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)
title_full_unstemmed Diet and lifestyle in relation to small intestinal cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)
title_sort Diet and lifestyle in relation to small intestinal cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)
dc.creator.none.fl_str_mv Ersoy Guller, Zeynep Betul
Harewood, Rhea
Weiderpass, Elisabete
Huybrechts, Inge
Jenab, Mazda
Huerta, José María
Sánchez, María-José
Jakszyn, Paula
Amiano, Pilar
Ardanaz, Eva
Agnoli, Claudia
Tumino, Rosario
Palli, Domenico
Skeie, Guri
Manjer, Jonas
Papier, Keren
Tjønneland, Anne
Eriksen, Anne Kirstine
Schulze, Matthias B.
Kaaks, Rudolf
Katzke, Verena Andrea
Bergmann, Manuela M.
Riboli, Elio
Gunter, Marc J.
Cross, Amanda J.
author Ersoy Guller, Zeynep Betul
author_facet Ersoy Guller, Zeynep Betul
Harewood, Rhea
Weiderpass, Elisabete
Huybrechts, Inge
Jenab, Mazda
Huerta, José María
Sánchez, María-José
Jakszyn, Paula
Amiano, Pilar
Ardanaz, Eva
Agnoli, Claudia
Tumino, Rosario
Palli, Domenico
Skeie, Guri
Manjer, Jonas
Papier, Keren
Tjønneland, Anne
Eriksen, Anne Kirstine
Schulze, Matthias B.
Kaaks, Rudolf
Katzke, Verena Andrea
Bergmann, Manuela M.
Riboli, Elio
Gunter, Marc J.
Cross, Amanda J.
author_role author
author2 Harewood, Rhea
Weiderpass, Elisabete
Huybrechts, Inge
Jenab, Mazda
Huerta, José María
Sánchez, María-José
Jakszyn, Paula
Amiano, Pilar
Ardanaz, Eva
Agnoli, Claudia
Tumino, Rosario
Palli, Domenico
Skeie, Guri
Manjer, Jonas
Papier, Keren
Tjønneland, Anne
Eriksen, Anne Kirstine
Schulze, Matthias B.
Kaaks, Rudolf
Katzke, Verena Andrea
Bergmann, Manuela M.
Riboli, Elio
Gunter, Marc J.
Cross, Amanda J.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
dc.subject.none.fl_str_mv Intestí prim -- Càncer
Adenocarcinoma
Carcinoide
Alimentació
Estil de vida
Alcohol
Hàbit de fumar
topic Intestí prim -- Càncer
Adenocarcinoma
Carcinoide
Alimentació
Estil de vida
Alcohol
Hàbit de fumar
description Purpose The incidence of small intestinal cancer (SIC) is increasing, however, its aetiology remains unclear due to a lack of data from large-scale prospective cohorts. We examined modifiable risk factors in relation to SIC overall and by histological subtype. Methods We analysed 450,107 participants enrolled in the European Prospective Investigation into Cancer and Nutrition cohort. Cox proportional hazards models were used to estimate univariable and multivariable hazard ratios (HRs) and 95% confidence intervals (CIs). Results During an average of 14.1 years of follow-up, 160 incident SICs (62 carcinoids, 51 adenocarcinomas) were identified. Whilst univariable models revealed a positive association for current versus never smokers and SIC (HR, 95% CI: 1.77, 1.21–2.60), this association attenuated in multivariable models. In energy-adjusted models, there was an inverse association across vegetable intake tertiles for SIC overall (HRT3vsT1, 95% CI: 0.48, 0.32–0.71, p-trend: < 0.001) and for carcinoids (HRT3vsT1, 95% CI: 0.44, 0.24–0.82, p-trend: 0.01); however, these attenuated in multivariable models. Total fat was also inversely associated with total SIC and both subtypes but only in the second tertile (SIC univariable HRT2vsT1, 95% CI: 0.57, 0.38–0.84; SIC multivariable HRT2vsT1, 95% CI: 0.55, 0.37–0.81). Physical activity, intake of alcohol, red or processed meat, dairy products, or fibre were not associated with SIC. Conclusion These exploratory analyses found limited evidence for a role of modifiable risk factors in SIC aetiology. However, sample size was limited, particularly for histologic subtypes; therefore, larger studies are needed to delineate these associations and robustly identify risk factors for SIC.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.14342/5232
https://doi.org/10.1007/s10552-023-01731-w
url http://hdl.handle.net/20.500.14342/5232
https://doi.org/10.1007/s10552-023-01731-w
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Cancer Causes and Control, 2023, 34: 927-937
dc.rights.none.fl_str_mv © L'autor/a
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © L'autor/a
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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