SOCS1-derived peptide administered by eye drops prevents retinal neuroinflammation and vascular leakage in experimental diabetes

Current treatments for diabetic retinopathy (DR) target late stages when vision has already been significantly a ected. Accumulating evidence suggests that neuroinflammation plays a major role in the pathogenesis of DR, resulting in the disruption of the blood-retinal barrier. Suppressors of cytokin...

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Autores: Hernández, Cristina, Bogdanov, Patricia, Gómez Guerrero, Carmen, Sampedro, Joel, Solà Adell, Cristina, Espejo, Carmen, García Ramírez, Marta, Prieto, Ignacio, Egido de los Ríos, Jesús, Simó, Rafael
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/690635
Acceso en línea:http://hdl.handle.net/10486/690635
https://dx.doi.org/10.3390/ijms20153615
Access Level:acceso abierto
Palabra clave:diabetic retinopathy
neuroinflammation
suppressors of cytokine signaling
microvascular impairment
db/db mouse
Medicina
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spelling SOCS1-derived peptide administered by eye drops prevents retinal neuroinflammation and vascular leakage in experimental diabetesHernández, CristinaBogdanov, PatriciaGómez Guerrero, CarmenSampedro, JoelSolà Adell, CristinaEspejo, CarmenGarcía Ramírez, MartaPrieto, IgnacioEgido de los Ríos, JesúsSimó, Rafaeldiabetic retinopathyneuroinflammationsuppressors of cytokine signalingmicrovascular impairmentdb/db mouseMedicinaCurrent treatments for diabetic retinopathy (DR) target late stages when vision has already been significantly a ected. Accumulating evidence suggests that neuroinflammation plays a major role in the pathogenesis of DR, resulting in the disruption of the blood-retinal barrier. Suppressors of cytokine signaling (SOCS) are cytokine-inducible proteins that function as a negative feedback loop regulating cytokine responses. On this basis, the aim of the present study was to evaluate the e ect of a SOCS1-derived peptide administered by eye drops (2 weeks) on retinal neuroinflammation and early microvascular abnormalities in a db/db mouse model. In brief, we found that SOCS1-derived peptide significantly reduced glial activation and neural apoptosis induced by diabetes, as well as retinal levels of proinflammatory cytokines. Moreover, a significant improvement of electroretinogram parameters was observed, thus revealing a clear impact of the histological findings on global retinal function. Finally, SOCS1-derived peptide prevented the disruption of the blood-retinal barrier. Overall, our results suggest that topical administration of SOCS1-derived peptide is e ective in preventing retinal neuroinflammation and early microvascular impairment. These findings could open up a new strategy for the treatment of early stages of DRThis study was supported by grants from the Ministerio de Economía y Competitividad (PI16/00541, SAF2015-63696-R, PI14/00386, PI17/01495 and DTS-2017/00203)MDPIDepartamento de MedicinaFacultad de Medicina20192019-07-24research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/690635https://dx.doi.org/10.3390/ijms20153615reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6906352026-06-23T12:46:27Z
dc.title.none.fl_str_mv SOCS1-derived peptide administered by eye drops prevents retinal neuroinflammation and vascular leakage in experimental diabetes
title SOCS1-derived peptide administered by eye drops prevents retinal neuroinflammation and vascular leakage in experimental diabetes
spellingShingle SOCS1-derived peptide administered by eye drops prevents retinal neuroinflammation and vascular leakage in experimental diabetes
Hernández, Cristina
diabetic retinopathy
neuroinflammation
suppressors of cytokine signaling
microvascular impairment
db/db mouse
Medicina
title_short SOCS1-derived peptide administered by eye drops prevents retinal neuroinflammation and vascular leakage in experimental diabetes
title_full SOCS1-derived peptide administered by eye drops prevents retinal neuroinflammation and vascular leakage in experimental diabetes
title_fullStr SOCS1-derived peptide administered by eye drops prevents retinal neuroinflammation and vascular leakage in experimental diabetes
title_full_unstemmed SOCS1-derived peptide administered by eye drops prevents retinal neuroinflammation and vascular leakage in experimental diabetes
title_sort SOCS1-derived peptide administered by eye drops prevents retinal neuroinflammation and vascular leakage in experimental diabetes
dc.creator.none.fl_str_mv Hernández, Cristina
Bogdanov, Patricia
Gómez Guerrero, Carmen
Sampedro, Joel
Solà Adell, Cristina
Espejo, Carmen
García Ramírez, Marta
Prieto, Ignacio
Egido de los Ríos, Jesús
Simó, Rafael
author Hernández, Cristina
author_facet Hernández, Cristina
Bogdanov, Patricia
Gómez Guerrero, Carmen
Sampedro, Joel
Solà Adell, Cristina
Espejo, Carmen
García Ramírez, Marta
Prieto, Ignacio
Egido de los Ríos, Jesús
Simó, Rafael
author_role author
author2 Bogdanov, Patricia
Gómez Guerrero, Carmen
Sampedro, Joel
Solà Adell, Cristina
Espejo, Carmen
García Ramírez, Marta
Prieto, Ignacio
Egido de los Ríos, Jesús
Simó, Rafael
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Medicina
Facultad de Medicina
dc.subject.none.fl_str_mv diabetic retinopathy
neuroinflammation
suppressors of cytokine signaling
microvascular impairment
db/db mouse
Medicina
topic diabetic retinopathy
neuroinflammation
suppressors of cytokine signaling
microvascular impairment
db/db mouse
Medicina
description Current treatments for diabetic retinopathy (DR) target late stages when vision has already been significantly a ected. Accumulating evidence suggests that neuroinflammation plays a major role in the pathogenesis of DR, resulting in the disruption of the blood-retinal barrier. Suppressors of cytokine signaling (SOCS) are cytokine-inducible proteins that function as a negative feedback loop regulating cytokine responses. On this basis, the aim of the present study was to evaluate the e ect of a SOCS1-derived peptide administered by eye drops (2 weeks) on retinal neuroinflammation and early microvascular abnormalities in a db/db mouse model. In brief, we found that SOCS1-derived peptide significantly reduced glial activation and neural apoptosis induced by diabetes, as well as retinal levels of proinflammatory cytokines. Moreover, a significant improvement of electroretinogram parameters was observed, thus revealing a clear impact of the histological findings on global retinal function. Finally, SOCS1-derived peptide prevented the disruption of the blood-retinal barrier. Overall, our results suggest that topical administration of SOCS1-derived peptide is e ective in preventing retinal neuroinflammation and early microvascular impairment. These findings could open up a new strategy for the treatment of early stages of DR
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-07-24
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/690635
https://dx.doi.org/10.3390/ijms20153615
url http://hdl.handle.net/10486/690635
https://dx.doi.org/10.3390/ijms20153615
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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