Transcranial static magnetic stimulation reduces seizures in a mouse model of Dravet syndrome

Dravet syndrome is a rare form of severe genetic epilepsy characterized by recurrent and long-lasting seizures. It appears around the first year of life, with a quick evolution toward an increase in the frequency of the seizures, accompanied by a delay in motor and cognitive development, and does no...

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Detalles Bibliográficos
Autor: Aguilar Lepe, Juan de los Reyes
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/42343
Acceso en línea:https://hdl.handle.net/10578/42343
Access Level:acceso abierto
Palabra clave:Dravet
Epilepsy
Magnetic stimulation
Non invasive neuromodulation
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spelling Transcranial static magnetic stimulation reduces seizures in a mouse model of Dravet syndromeAguilar Lepe, Juan de los ReyesDravetEpilepsyMagnetic stimulationNon invasive neuromodulationDravet syndrome is a rare form of severe genetic epilepsy characterized by recurrent and long-lasting seizures. It appears around the first year of life, with a quick evolution toward an increase in the frequency of the seizures, accompanied by a delay in motor and cognitive development, and does not respond well to antiepileptic medication. Most patients carry a mutation in the gene SCN1A encoding the a subunit of the voltage-gated sodium channel Nav1.1, resulting in hyperexcitability of neural circuits and seizure onset. In this work, we applied transcranial static magnetic stimulation (tSMS), a non-invasive, safe, easy-to-use and affordable neuromodulatory tool that reduces neural excitability in a mouse model of Dravet syndrome. We demonstrate that tSMS dramatically reduced the number of crises. Furthermore, crises recorded in the presence of the tSMS were shorter and less intense than in the sham condition. Since tSMS has demonstrated its efficacy at reducing cortical excitability in humans without showing unwanted side effects, in an attempt to anticipate a possible use of tSMS for Dravet Syndrome patients, we performed a numerical simulation in which the magnetic field generated by the magnet was modeled to estimate the magnetic field intensity reached in the cerebral cortex, which could help to design stimulation strategies in these patients. Our results provide a proof of concept for nonpharmacological treatment of Dravet syndrome, which opens the door to the design of new protocols for treatment.Academic Press Inc.202520252023info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://hdl.handle.net/10578/42343reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaInglésinfo:eu-repo/semantics/openAccessoai:ruidera.uclm.es:10578/423432026-05-27T07:36:41Z
dc.title.none.fl_str_mv Transcranial static magnetic stimulation reduces seizures in a mouse model of Dravet syndrome
title Transcranial static magnetic stimulation reduces seizures in a mouse model of Dravet syndrome
spellingShingle Transcranial static magnetic stimulation reduces seizures in a mouse model of Dravet syndrome
Aguilar Lepe, Juan de los Reyes
Dravet
Epilepsy
Magnetic stimulation
Non invasive neuromodulation
title_short Transcranial static magnetic stimulation reduces seizures in a mouse model of Dravet syndrome
title_full Transcranial static magnetic stimulation reduces seizures in a mouse model of Dravet syndrome
title_fullStr Transcranial static magnetic stimulation reduces seizures in a mouse model of Dravet syndrome
title_full_unstemmed Transcranial static magnetic stimulation reduces seizures in a mouse model of Dravet syndrome
title_sort Transcranial static magnetic stimulation reduces seizures in a mouse model of Dravet syndrome
dc.creator.none.fl_str_mv Aguilar Lepe, Juan de los Reyes
author Aguilar Lepe, Juan de los Reyes
author_facet Aguilar Lepe, Juan de los Reyes
author_role author
dc.subject.none.fl_str_mv Dravet
Epilepsy
Magnetic stimulation
Non invasive neuromodulation
topic Dravet
Epilepsy
Magnetic stimulation
Non invasive neuromodulation
description Dravet syndrome is a rare form of severe genetic epilepsy characterized by recurrent and long-lasting seizures. It appears around the first year of life, with a quick evolution toward an increase in the frequency of the seizures, accompanied by a delay in motor and cognitive development, and does not respond well to antiepileptic medication. Most patients carry a mutation in the gene SCN1A encoding the a subunit of the voltage-gated sodium channel Nav1.1, resulting in hyperexcitability of neural circuits and seizure onset. In this work, we applied transcranial static magnetic stimulation (tSMS), a non-invasive, safe, easy-to-use and affordable neuromodulatory tool that reduces neural excitability in a mouse model of Dravet syndrome. We demonstrate that tSMS dramatically reduced the number of crises. Furthermore, crises recorded in the presence of the tSMS were shorter and less intense than in the sham condition. Since tSMS has demonstrated its efficacy at reducing cortical excitability in humans without showing unwanted side effects, in an attempt to anticipate a possible use of tSMS for Dravet Syndrome patients, we performed a numerical simulation in which the magnetic field generated by the magnet was modeled to estimate the magnetic field intensity reached in the cerebral cortex, which could help to design stimulation strategies in these patients. Our results provide a proof of concept for nonpharmacological treatment of Dravet syndrome, which opens the door to the design of new protocols for treatment.
publishDate 2023
dc.date.none.fl_str_mv 2023
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10578/42343
url https://hdl.handle.net/10578/42343
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc.
publisher.none.fl_str_mv Academic Press Inc.
dc.source.none.fl_str_mv reponame:RUIdeRA. Repositorio Institucional de la UCLM
instname:Universidad de Castilla-La Mancha
instname_str Universidad de Castilla-La Mancha
reponame_str RUIdeRA. Repositorio Institucional de la UCLM
collection RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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