Identification of Resistance to Exogenous Thyroxine in Humans

[Background]: Thyroxine (T4) to triiodothyronine (T3) deiodination in the hypothalamus/pituitary is mediated by deiodinase type-2 (D2) activity. Dio2(−/−) mice show central resistance to exogenous T4. Patients with resistance to exogenous thyroxine (RETH) have not been described. The aim of this stu...

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Detalles Bibliográficos
Autores: Lacámara, Nerea, Lecumberri, Beatriz, Barquiel, Beatriz, Escribano, Arancha, González-Casado, Isabel, Álvarez-Escolá, Cristina, Aleixandre-Blanquer, Fernando, Morales, Francisco, Alfayate, Rocío, Bernal-Soriano, Mari Carmen, Miralles, Raquel, Yildirim Simsir, Ilgin, Gökhan Özgen, Ahmet, Bernal, Juan, Berbel, Pere, Moreno, José C.
Tipo de recurso: artículo
Estado:Versión enviada para evaluación y publicación
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/232361
Acceso en línea:http://hdl.handle.net/10261/232361
Access Level:acceso abierto
Palabra clave:Resistance to levothyroxine
RETH
Biomarker T3/rT3 ratio
Iatrogenic hyperthyroidism
T4+T3 therapy for hypothyroidism
Thyroid hormone metabolism
Iodothyronine ratios
Descripción
Sumario:[Background]: Thyroxine (T4) to triiodothyronine (T3) deiodination in the hypothalamus/pituitary is mediated by deiodinase type-2 (D2) activity. Dio2(−/−) mice show central resistance to exogenous T4. Patients with resistance to exogenous thyroxine (RETH) have not been described. The aim of this study was to identify hypothyroid patients with thyrotropin (TSH) unresponsiveness to levothyroxine (LT4) and to characterize the clinical, hormonal, and genetic features of human RETH.

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