Tuberculosis outbreak caused by Mycobacterium caprae in a rabbit farm in Spain
[EN] Animal tuberculosis remains a great source of socioeconomic and health concern worldwide. Its main causative agents, Mycobacterium bovis and Mycobacterium caprae, have been isolated from many different domestic and wild animals. Naturally, occurring tuberculosis is extremely rare in rabbits, an...
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión enviada para evaluación y publicación |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Universidad de León |
| Repositorio: | BULERIA. Repositorio Institucional de la Universidad de León |
| OAI Identifier: | oai:buleria.unileon.es:10612/26495 |
| Acceso en línea: | https://onlinelibrary.wiley.com/doi/10.1111/tbed.13366 https://hdl.handle.net/10612/26495 |
| Access Level: | acceso abierto |
| Palabra clave: | Sanidad animal Veterinaria Tuberculosis Outbreak Mycobacterium caprae Rabbit Zoonoses 3109 Ciencias Veterinarias |
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Tuberculosis outbreak caused by Mycobacterium caprae in a rabbit farm in SpainSevilla, Iker A.Arnal, María CruzFuertes Franco, MiguelMartín, ElviraComenge, JesúsElguezabal, NataliaFernández de Luco, DanielGarrido, Joseba M.Sanidad animalVeterinariaTuberculosisOutbreakMycobacterium capraeRabbitZoonoses3109 Ciencias Veterinarias[EN] Animal tuberculosis remains a great source of socioeconomic and health concern worldwide. Its main causative agents, Mycobacterium bovis and Mycobacterium caprae, have been isolated from many different domestic and wild animals. Naturally, occurring tuberculosis is extremely rare in rabbits, and implication of M. caprae has never been reported earlier. This study describes a severe tuberculosis outbreak caused by M. caprae in a Spanish farm of rabbits raised for meat for human consumption. The disease was first identified in a cachectic dam, and then it was confirmed in ten does with similar clinical signs. Subsequently, a depopulation operation was ordered for public health, animal welfare and environmental reasons. To broaden knowledge of spontaneous tuberculosis in rabbits, a study focused on pathological, epidemiological and diagnostic aspects was carried out on 51 does and 16 kittens after receiving the necessary authorizations. These animals were subjected to a modified intradermal test. After being euthanized, rabbits were examined for the presence of visible tuberculosis-compatible lesions. Lung, kidney, caecal appendix and sacculus rotundus samples underwent microbiological and anatomopathological analysis. Infection was revealed by at least one of the methods used in 71% of dams and in 44% of kittens. The intradermal test was shown to be a good indicator of infection. Lung was the tissue for which more animals were positive but renal and intestinal tissues were also affected in many cases. Apparently, M. caprae spread mainly through the aerogenous route. Infection was pathologically characterized by the absence of evident fibrous capsules surrounding granulomas. A spoligotype (SB0415) frequently found in this area was considered responsible for the outbreak but the source could not be established. Regardless of the exceptional nature of animal tuberculosis in this host, rabbit industry might not escape from its effects and therefore, current biosafety and surveillance strategies should also consider this diseaseNOWe would like to thank the rabbit farm owner and the competent authorities from the Government of Aragón for allowing us to carry out this study. We are also grateful for the technical support provided by Amaia Etxezarreta and Mariví Geijo from NEIKER. The work of Iker A. Sevilla, Miguel Fuertes, Natalia Elguezabal and Joseba M. Garrido was supported with funds from the Department of Economic Development and Infrastructures of the Basque Government. The work of María Cruz Arnal and Daniel Fernández de Luco was supported with funds from the Government of Aragón for health surveillance on wildlifeWileySanidad AnimalFacultad de Veterinaria2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/submittedVersionhttps://onlinelibrary.wiley.com/doi/10.1111/tbed.13366https://hdl.handle.net/10612/26495reponame:BULERIA. Repositorio Institucional de la Universidad de Leóninstname:Universidad de LeónIngléshttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:buleria.unileon.es:10612/264952026-06-24T12:43:27Z |
| dc.title.none.fl_str_mv |
Tuberculosis outbreak caused by Mycobacterium caprae in a rabbit farm in Spain |
| title |
Tuberculosis outbreak caused by Mycobacterium caprae in a rabbit farm in Spain |
| spellingShingle |
Tuberculosis outbreak caused by Mycobacterium caprae in a rabbit farm in Spain Sevilla, Iker A. Sanidad animal Veterinaria Tuberculosis Outbreak Mycobacterium caprae Rabbit Zoonoses 3109 Ciencias Veterinarias |
| title_short |
Tuberculosis outbreak caused by Mycobacterium caprae in a rabbit farm in Spain |
| title_full |
Tuberculosis outbreak caused by Mycobacterium caprae in a rabbit farm in Spain |
| title_fullStr |
Tuberculosis outbreak caused by Mycobacterium caprae in a rabbit farm in Spain |
| title_full_unstemmed |
Tuberculosis outbreak caused by Mycobacterium caprae in a rabbit farm in Spain |
| title_sort |
Tuberculosis outbreak caused by Mycobacterium caprae in a rabbit farm in Spain |
| dc.creator.none.fl_str_mv |
Sevilla, Iker A. Arnal, María Cruz Fuertes Franco, Miguel Martín, Elvira Comenge, Jesús Elguezabal, Natalia Fernández de Luco, Daniel Garrido, Joseba M. |
| author |
Sevilla, Iker A. |
| author_facet |
Sevilla, Iker A. Arnal, María Cruz Fuertes Franco, Miguel Martín, Elvira Comenge, Jesús Elguezabal, Natalia Fernández de Luco, Daniel Garrido, Joseba M. |
| author_role |
author |
| author2 |
Arnal, María Cruz Fuertes Franco, Miguel Martín, Elvira Comenge, Jesús Elguezabal, Natalia Fernández de Luco, Daniel Garrido, Joseba M. |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Sanidad Animal Facultad de Veterinaria |
| dc.subject.none.fl_str_mv |
Sanidad animal Veterinaria Tuberculosis Outbreak Mycobacterium caprae Rabbit Zoonoses 3109 Ciencias Veterinarias |
| topic |
Sanidad animal Veterinaria Tuberculosis Outbreak Mycobacterium caprae Rabbit Zoonoses 3109 Ciencias Veterinarias |
| description |
[EN] Animal tuberculosis remains a great source of socioeconomic and health concern worldwide. Its main causative agents, Mycobacterium bovis and Mycobacterium caprae, have been isolated from many different domestic and wild animals. Naturally, occurring tuberculosis is extremely rare in rabbits, and implication of M. caprae has never been reported earlier. This study describes a severe tuberculosis outbreak caused by M. caprae in a Spanish farm of rabbits raised for meat for human consumption. The disease was first identified in a cachectic dam, and then it was confirmed in ten does with similar clinical signs. Subsequently, a depopulation operation was ordered for public health, animal welfare and environmental reasons. To broaden knowledge of spontaneous tuberculosis in rabbits, a study focused on pathological, epidemiological and diagnostic aspects was carried out on 51 does and 16 kittens after receiving the necessary authorizations. These animals were subjected to a modified intradermal test. After being euthanized, rabbits were examined for the presence of visible tuberculosis-compatible lesions. Lung, kidney, caecal appendix and sacculus rotundus samples underwent microbiological and anatomopathological analysis. Infection was revealed by at least one of the methods used in 71% of dams and in 44% of kittens. The intradermal test was shown to be a good indicator of infection. Lung was the tissue for which more animals were positive but renal and intestinal tissues were also affected in many cases. Apparently, M. caprae spread mainly through the aerogenous route. Infection was pathologically characterized by the absence of evident fibrous capsules surrounding granulomas. A spoligotype (SB0415) frequently found in this area was considered responsible for the outbreak but the source could not be established. Regardless of the exceptional nature of animal tuberculosis in this host, rabbit industry might not escape from its effects and therefore, current biosafety and surveillance strategies should also consider this disease |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/submittedVersion |
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article |
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submittedVersion |
| dc.identifier.none.fl_str_mv |
https://onlinelibrary.wiley.com/doi/10.1111/tbed.13366 https://hdl.handle.net/10612/26495 |
| url |
https://onlinelibrary.wiley.com/doi/10.1111/tbed.13366 https://hdl.handle.net/10612/26495 |
| dc.language.none.fl_str_mv |
Inglés |
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Inglés |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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Wiley |
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Wiley |
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reponame:BULERIA. Repositorio Institucional de la Universidad de León instname:Universidad de León |
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Universidad de León |
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BULERIA. Repositorio Institucional de la Universidad de León |
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BULERIA. Repositorio Institucional de la Universidad de León |
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