Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses Such as SARS-CoV-2

The current pandemic is urgently demanding the development of alternative materials capable of inactivating the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes the coronavirus 2019 (COVID-19) disease. Calcium alginate is a crosslinked hydrophilic biopolymer with an immense r...

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Detalhes bibliográficos
Autores: Cano Vicent, Alba, Hashimoto, Rina, Takayama, Kazuo, Serrano Aroca, Ángel
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Universidad Católica de Valencia San Vicente Mártir
Repositorio:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
Idioma:inglés
OAI Identifier:oai:riucv.ucv.es:20.500.12466/7186
Acesso em linha:https://hdl.handle.net/20.500.12466/7186
Access Level:acceso abierto
Palavra-chave:Calcium alginate
SARS-CoV-2
Bacteriophage
Phi 6
Biomaterials
Films
Hydrogels
24 Ciencias de la Vida
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spelling Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses Such as SARS-CoV-2Cano Vicent, AlbaHashimoto, RinaTakayama, KazuoSerrano Aroca, ÁngelCalcium alginateSARS-CoV-2BacteriophagePhi 6BiomaterialsFilmsHydrogels24 Ciencias de la VidaThe current pandemic is urgently demanding the development of alternative materials capable of inactivating the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes the coronavirus 2019 (COVID-19) disease. Calcium alginate is a crosslinked hydrophilic biopolymer with an immense range of biomedical applications due to its excellent chemical, physical, and biological properties. In this study, the cytotoxicity and antiviral activity of calcium alginate in the form of films were studied. The results showed that these films, prepared by solvent casting and subsequent crosslinking with calcium cations, are biocompatible in human keratinocytes and are capable of inactivating enveloped viruses such as bacteriophage phi 6 with a 1.43-log reduction (94.92% viral inactivation) and SARS-CoV-2 Delta variant with a 1.64-log reduction (96.94% viral inactivation) in virus titers. The antiviral activity of these calcium alginate films can be attributed to its compacted negative charges that may bind to viral envelopes inactivating membrane receptors.20252025-12-1720222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12466/7186reponame:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártirinstname:Universidad Católica de Valencia San Vicente MártirInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riucv.ucv.es:20.500.12466/71862026-06-19T08:32:07Z
dc.title.none.fl_str_mv Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses Such as SARS-CoV-2
title Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses Such as SARS-CoV-2
spellingShingle Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses Such as SARS-CoV-2
Cano Vicent, Alba
Calcium alginate
SARS-CoV-2
Bacteriophage
Phi 6
Biomaterials
Films
Hydrogels
24 Ciencias de la Vida
title_short Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses Such as SARS-CoV-2
title_full Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses Such as SARS-CoV-2
title_fullStr Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses Such as SARS-CoV-2
title_full_unstemmed Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses Such as SARS-CoV-2
title_sort Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses Such as SARS-CoV-2
dc.creator.none.fl_str_mv Cano Vicent, Alba
Hashimoto, Rina
Takayama, Kazuo
Serrano Aroca, Ángel
author Cano Vicent, Alba
author_facet Cano Vicent, Alba
Hashimoto, Rina
Takayama, Kazuo
Serrano Aroca, Ángel
author_role author
author2 Hashimoto, Rina
Takayama, Kazuo
Serrano Aroca, Ángel
author2_role author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Calcium alginate
SARS-CoV-2
Bacteriophage
Phi 6
Biomaterials
Films
Hydrogels
24 Ciencias de la Vida
topic Calcium alginate
SARS-CoV-2
Bacteriophage
Phi 6
Biomaterials
Films
Hydrogels
24 Ciencias de la Vida
description The current pandemic is urgently demanding the development of alternative materials capable of inactivating the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes the coronavirus 2019 (COVID-19) disease. Calcium alginate is a crosslinked hydrophilic biopolymer with an immense range of biomedical applications due to its excellent chemical, physical, and biological properties. In this study, the cytotoxicity and antiviral activity of calcium alginate in the form of films were studied. The results showed that these films, prepared by solvent casting and subsequent crosslinking with calcium cations, are biocompatible in human keratinocytes and are capable of inactivating enveloped viruses such as bacteriophage phi 6 with a 1.43-log reduction (94.92% viral inactivation) and SARS-CoV-2 Delta variant with a 1.64-log reduction (96.94% viral inactivation) in virus titers. The antiviral activity of these calcium alginate films can be attributed to its compacted negative charges that may bind to viral envelopes inactivating membrane receptors.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01
2022
2022-01-01
2025
2025-12-17
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12466/7186
url https://hdl.handle.net/20.500.12466/7186
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
instname:Universidad Católica de Valencia San Vicente Mártir
instname_str Universidad Católica de Valencia San Vicente Mártir
reponame_str RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
collection RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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