Highly Enantioselective Iridium-Catalyzed Hydrogenation of Cyclic Enamides
The MaxPHOX-Ir catalyst system provided the highest selectivity ever reported for the redn. of cyclic enamides derived from α- and β-tetralones. This result indicates that iridium catalysts are also proficient in reducing alkenes bearing metal-coordinating groups. In the present system, selectivity...
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/101981 |
| Acceso en línea: | https://hdl.handle.net/2445/101981 |
| Access Level: | acceso abierto |
| Palabra clave: | Hidrogenació Catàlisi asimètrica Enantiòmers Hydrogenation Enantioselective catalysis Enantiomers |
| Sumario: | The MaxPHOX-Ir catalyst system provided the highest selectivity ever reported for the redn. of cyclic enamides derived from α- and β-tetralones. This result indicates that iridium catalysts are also proficient in reducing alkenes bearing metal-coordinating groups. In the present system, selectivity was pressure-dependent: in most cases, a decrease in the H2 pressure to 3 bar resulted in an increase in enantioselectivity. Moreover, the process can be carried out in environmentally friendly solvents, such as methanol and Et acetate, with no loss of selectivity. |
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