Influence of behavioral traits in the inter-individual variability of nociceptive, emotional and cognitive manifestations of neuropathic pain

Neuropathic pain is a complex disorder associated with emotional and cognitive deficits that may impair nociceptive manifestations. There is high inter-individual variability in the manifestations of human neuropathic pain, which largely depends on personality traits. We aim to identify the influenc...

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Authors: Martínez-Navarro, Miriam, Lara Mayorga, Itzel Montserrat, 1982-, Negrete Buela, Roger, Bilecki, Wiktor, Wawrzczak-Bargiela, Agnieszka, Gonçalves, Leonor, Dickenson, Anthony Henry, Przewlocki, Ryszard, Baños i Díez, Josep Eladi, Maldonado, Rafael, 1961-
Format: article
Status:Versión aceptada para publicación
Publication Date:2019
Country:España
Institution:Universitat Pompeu Fabra
Repository:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/36362
Online Access:http://hdl.handle.net/10230/36362
http://dx.doi.org/10.1016/j.neuropharm.2019.01.012
Access Level:Open access
Keyword:Dolor
Conducta (Psicologia)
Angoixa
Depressius
Nucli amigdaloide
id ES_b6f8bccae097d6ad2e2a26183b2bcc76
oai_identifier_str oai:repositori.upf.edu:10230/36362
network_acronym_str ES
network_name_str España
repository_id_str
spelling Influence of behavioral traits in the inter-individual variability of nociceptive, emotional and cognitive manifestations of neuropathic painMartínez-Navarro, MiriamLara Mayorga, Itzel Montserrat, 1982-Negrete Buela, RogerBilecki, WiktorWawrzczak-Bargiela, AgnieszkaGonçalves, LeonorDickenson, Anthony HenryPrzewlocki, RyszardBaños i Díez, Josep EladiMaldonado, Rafael, 1961-DolorConducta (Psicologia)AngoixaDepressiusNucli amigdaloideNeuropathic pain is a complex disorder associated with emotional and cognitive deficits that may impair nociceptive manifestations. There is high inter-individual variability in the manifestations of human neuropathic pain, which largely depends on personality traits. We aim to identify the influence of different behavioral traits in the interindividual vulnerability to neuropathic pain manifestations using behavioral, electrophysiological and genetic approaches. We first selected mice with extreme social and emotional traits and look for correlation with the spontaneous neuronal activity in the central amygdala. Neuropathic pain was induced to these mice to evaluate the influence of behavioral traits on nociceptive manifestations and gene expression profiles in the amygdala. Our results show an association of the spontaneous central amygdala neuronal activity with the sociability behavior. We demonstrate that low sociable, high anxious and low depressive phenotypes develop enhanced nociceptive hypersensitivity after nerve injury. However, greater emotional alterations and cognitive impairment are observed in high sociable, anxious-like and depressive-like mice, indicating that nociceptive, emotional and cognitive manifestations of neuropathic pain do not correlate with each other. Gene analyses identify high Pdyn and Il6 levels in the amygdala as indicative of enhanced nociceptive hypersensitivity and reveal an association between high Gadd45 expression and attenuated emotional and cognitive manifestations of neuropathic pain.This work was supported by the European Commission, FP7 (#HEALTH-F2-2013- 602891), the Spanish Ministerio de Economía y Competitividad MINECO (#SAF2014-59648-P and #SAF2017-84060-R), the Spanish Instituto de Salud Carlos III, RETICS-RTA (#RD12/0028/0023) and the Generalitat de Catalunya, AGAUR (#2014-SGR-1547) and Polish Ministry of Science and Education (#3070/7.PR/2014/2). M.M.N. and R.N. are recipients of a predoctoral fellowship from the Spanish Ministerio de Educación, Cultura y Deporte (MECD). I.M.L.M. is recipient of a predoctoral fellowship from the Mexican Consejo Nacional de Ciencia y Tecnología (CONACyT). FEDER partial funding is also acknowledged. W.B. and A.B. are recipients of Polish Ministry of Science and Education and European Commission grantsElsevier20192019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/36362http://dx.doi.org/10.1016/j.neuropharm.2019.01.012reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésNeuropharmacology. 2019;148:291-304info:eu-repo/grantAgreement/EC/FP7/602891info:eu-repo/grantAgreement/ES/1PE/SAF2014-59648-Pinfo:eu-repo/grantAgreement/ES/1PE/SAF2017-84060-R© Elsevier http://dx.doi.org/10.1016/j.neuropharm.2019.01.012info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/363622026-06-12T07:21:37Z
dc.title.none.fl_str_mv Influence of behavioral traits in the inter-individual variability of nociceptive, emotional and cognitive manifestations of neuropathic pain
title Influence of behavioral traits in the inter-individual variability of nociceptive, emotional and cognitive manifestations of neuropathic pain
spellingShingle Influence of behavioral traits in the inter-individual variability of nociceptive, emotional and cognitive manifestations of neuropathic pain
Martínez-Navarro, Miriam
Dolor
Conducta (Psicologia)
Angoixa
Depressius
Nucli amigdaloide
title_short Influence of behavioral traits in the inter-individual variability of nociceptive, emotional and cognitive manifestations of neuropathic pain
title_full Influence of behavioral traits in the inter-individual variability of nociceptive, emotional and cognitive manifestations of neuropathic pain
title_fullStr Influence of behavioral traits in the inter-individual variability of nociceptive, emotional and cognitive manifestations of neuropathic pain
title_full_unstemmed Influence of behavioral traits in the inter-individual variability of nociceptive, emotional and cognitive manifestations of neuropathic pain
title_sort Influence of behavioral traits in the inter-individual variability of nociceptive, emotional and cognitive manifestations of neuropathic pain
dc.creator.none.fl_str_mv Martínez-Navarro, Miriam
Lara Mayorga, Itzel Montserrat, 1982-
Negrete Buela, Roger
Bilecki, Wiktor
Wawrzczak-Bargiela, Agnieszka
Gonçalves, Leonor
Dickenson, Anthony Henry
Przewlocki, Ryszard
Baños i Díez, Josep Eladi
Maldonado, Rafael, 1961-
author Martínez-Navarro, Miriam
author_facet Martínez-Navarro, Miriam
Lara Mayorga, Itzel Montserrat, 1982-
Negrete Buela, Roger
Bilecki, Wiktor
Wawrzczak-Bargiela, Agnieszka
Gonçalves, Leonor
Dickenson, Anthony Henry
Przewlocki, Ryszard
Baños i Díez, Josep Eladi
Maldonado, Rafael, 1961-
author_role author
author2 Lara Mayorga, Itzel Montserrat, 1982-
Negrete Buela, Roger
Bilecki, Wiktor
Wawrzczak-Bargiela, Agnieszka
Gonçalves, Leonor
Dickenson, Anthony Henry
Przewlocki, Ryszard
Baños i Díez, Josep Eladi
Maldonado, Rafael, 1961-
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Dolor
Conducta (Psicologia)
Angoixa
Depressius
Nucli amigdaloide
topic Dolor
Conducta (Psicologia)
Angoixa
Depressius
Nucli amigdaloide
description Neuropathic pain is a complex disorder associated with emotional and cognitive deficits that may impair nociceptive manifestations. There is high inter-individual variability in the manifestations of human neuropathic pain, which largely depends on personality traits. We aim to identify the influence of different behavioral traits in the interindividual vulnerability to neuropathic pain manifestations using behavioral, electrophysiological and genetic approaches. We first selected mice with extreme social and emotional traits and look for correlation with the spontaneous neuronal activity in the central amygdala. Neuropathic pain was induced to these mice to evaluate the influence of behavioral traits on nociceptive manifestations and gene expression profiles in the amygdala. Our results show an association of the spontaneous central amygdala neuronal activity with the sociability behavior. We demonstrate that low sociable, high anxious and low depressive phenotypes develop enhanced nociceptive hypersensitivity after nerve injury. However, greater emotional alterations and cognitive impairment are observed in high sociable, anxious-like and depressive-like mice, indicating that nociceptive, emotional and cognitive manifestations of neuropathic pain do not correlate with each other. Gene analyses identify high Pdyn and Il6 levels in the amygdala as indicative of enhanced nociceptive hypersensitivity and reveal an association between high Gadd45 expression and attenuated emotional and cognitive manifestations of neuropathic pain.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/36362
http://dx.doi.org/10.1016/j.neuropharm.2019.01.012
url http://hdl.handle.net/10230/36362
http://dx.doi.org/10.1016/j.neuropharm.2019.01.012
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Neuropharmacology. 2019;148:291-304
info:eu-repo/grantAgreement/EC/FP7/602891
info:eu-repo/grantAgreement/ES/1PE/SAF2014-59648-P
info:eu-repo/grantAgreement/ES/1PE/SAF2017-84060-R
dc.rights.none.fl_str_mv © Elsevier http://dx.doi.org/10.1016/j.neuropharm.2019.01.012
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier http://dx.doi.org/10.1016/j.neuropharm.2019.01.012
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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