Toxic epidermal necrolysis: A paradigm of critical illness

Toxic epidermal necrolysis is an adverse immunological skin reaction secondary in most cases to the administration of a drug. Toxic epidermal necrolysis, Stevens-Johnson syndrome, and multiform exudative erythema are part of the same disease spectrum. The mortality rate from toxic epidermal necrolys...

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Detalhes bibliográficos
Autores: Estrella Alonso, Alfonso, Aramburú González, José Antonio, González Ruiz, Mercedes Yolanda, Cachafeiro, Lucía, Sánchez Sánchez, Manuel, Lorente Balanza, José Ángel
Tipo de documento: artigo
Data de publicação:2017
País:España
Recursos:Universidad Europea (UEM)
Repositório:ABACUS. Repositorio de Producción Científica
Idioma:inglês
OAI Identifier:oai:abacus.universidadeuropea.com:11268/9802
Acesso em linha:http://hdl.handle.net/11268/9802
Access Level:Acceso aberto
Palavra-chave:Enfermedades de la piel
Terapéutica
Enfermedad de la piel
Tratamiento médico
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spelling Toxic epidermal necrolysis: A paradigm of critical illnessNecrólisis epidérmica tóxica: un paradigma de enfermedad críticaEstrella Alonso, AlfonsoAramburú González, José AntonioGonzález Ruiz, Mercedes YolandaCachafeiro, LucíaSánchez Sánchez, ManuelLorente Balanza, José ÁngelEnfermedades de la pielTerapéuticaEnfermedad de la pielTratamiento médicoToxic epidermal necrolysis is an adverse immunological skin reaction secondary in most cases to the administration of a drug. Toxic epidermal necrolysis, Stevens-Johnson syndrome, and multiform exudative erythema are part of the same disease spectrum. The mortality rate from toxic epidermal necrolysis is approximately 30%. The pathophysiology of toxic epidermal necrolysis is similar in many respects to that of superficial skin burns. Mucosal involvement of the ocular and genital epithelium is associated with serious sequelae if the condition is not treated early. It is generally accepted that patients with toxic epidermal necrolysis are better treated in burn units, which are experienced in the management of patients with extensive skin loss. Treatment includes support, elimination, and coverage with biosynthetic derivatives of the skin in affected areas, treatment of mucosal involvement, and specific immunosuppressive treatment. Of the treatments tested, only immunoglobulin G and cyclosporin A are currently used in most centers, even though there is no solid evidence to recommend any specific treatment. The particular aspects of the treatment of this disease include the prevention of sequelae related to the formation of synechiae, eye care to prevent serious sequelae that can lead to blindness, and specific immunosuppressive treatment. Better knowledge of the management principles of toxic epidermal necrolysis will lead to better disease management, higher survival rates, and lower prevalence of sequelae.20212021-01-2820172017-01-0120172017-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articlehttp://hdl.handle.net/11268/9802reponame:ABACUS. Repositorio de Producción Científicainstname:Universidad Europea (UEM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:abacus.universidadeuropea.com:11268/98022026-06-11T12:41:27Z
dc.title.none.fl_str_mv Toxic epidermal necrolysis: A paradigm of critical illness
Necrólisis epidérmica tóxica: un paradigma de enfermedad crítica
title Toxic epidermal necrolysis: A paradigm of critical illness
spellingShingle Toxic epidermal necrolysis: A paradigm of critical illness
Estrella Alonso, Alfonso
Enfermedades de la piel
Terapéutica
Enfermedad de la piel
Tratamiento médico
title_short Toxic epidermal necrolysis: A paradigm of critical illness
title_full Toxic epidermal necrolysis: A paradigm of critical illness
title_fullStr Toxic epidermal necrolysis: A paradigm of critical illness
title_full_unstemmed Toxic epidermal necrolysis: A paradigm of critical illness
title_sort Toxic epidermal necrolysis: A paradigm of critical illness
dc.creator.none.fl_str_mv Estrella Alonso, Alfonso
Aramburú González, José Antonio
González Ruiz, Mercedes Yolanda
Cachafeiro, Lucía
Sánchez Sánchez, Manuel
Lorente Balanza, José Ángel
author Estrella Alonso, Alfonso
author_facet Estrella Alonso, Alfonso
Aramburú González, José Antonio
González Ruiz, Mercedes Yolanda
Cachafeiro, Lucía
Sánchez Sánchez, Manuel
Lorente Balanza, José Ángel
author_role author
author2 Aramburú González, José Antonio
González Ruiz, Mercedes Yolanda
Cachafeiro, Lucía
Sánchez Sánchez, Manuel
Lorente Balanza, José Ángel
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Enfermedades de la piel
Terapéutica
Enfermedad de la piel
Tratamiento médico
topic Enfermedades de la piel
Terapéutica
Enfermedad de la piel
Tratamiento médico
description Toxic epidermal necrolysis is an adverse immunological skin reaction secondary in most cases to the administration of a drug. Toxic epidermal necrolysis, Stevens-Johnson syndrome, and multiform exudative erythema are part of the same disease spectrum. The mortality rate from toxic epidermal necrolysis is approximately 30%. The pathophysiology of toxic epidermal necrolysis is similar in many respects to that of superficial skin burns. Mucosal involvement of the ocular and genital epithelium is associated with serious sequelae if the condition is not treated early. It is generally accepted that patients with toxic epidermal necrolysis are better treated in burn units, which are experienced in the management of patients with extensive skin loss. Treatment includes support, elimination, and coverage with biosynthetic derivatives of the skin in affected areas, treatment of mucosal involvement, and specific immunosuppressive treatment. Of the treatments tested, only immunoglobulin G and cyclosporin A are currently used in most centers, even though there is no solid evidence to recommend any specific treatment. The particular aspects of the treatment of this disease include the prevention of sequelae related to the formation of synechiae, eye care to prevent serious sequelae that can lead to blindness, and specific immunosuppressive treatment. Better knowledge of the management principles of toxic epidermal necrolysis will lead to better disease management, higher survival rates, and lower prevalence of sequelae.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01
2017
2017-01-01
2021
2021-01-28
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/11268/9802
url http://hdl.handle.net/11268/9802
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:ABACUS. Repositorio de Producción Científica
instname:Universidad Europea (UEM)
instname_str Universidad Europea (UEM)
reponame_str ABACUS. Repositorio de Producción Científica
collection ABACUS. Repositorio de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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