Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain

Several anticancer properties have been largely attributed to phenolics in in vivo and in vitro studies, but epidemiologic evidence is still scarce. Furthermore, some classes have not been studied in relation to gastric cancer (GC). The aim of this study was to assess the relationship between the in...

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Autores: Rubín García, María, Vitelli Storelli, Facundo, Molina de la Torre, Antonio José, Zamora-Ros, Raul, Aragonès Sanz, Núria, Adarnaz, Eva, Castaño-Vinyals, Gemma, Obón Santacana, Mireia, Gómez Acebo, Inés, Molina Barceló, Ana, Fernández Tardón, Guillermo, Jiménez Moleón, José Juan, Alguacil, Juan, Chirlaque, María Dolores, Toledo Atucha, Estefanía, Pérez Gómez, Beatriz, Pollán, Marina, Kogevinas, Manolis, Martín Sánchez, Vicente
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/173806
Acceso en línea:https://hdl.handle.net/2445/173806
Access Level:acceso abierto
Palabra clave:Càncer d'estómac
Nutrició
Epidemiologia
Stomach cancer
Nutrition
Epidemiology
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spelling Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-SpainRubín García, MaríaVitelli Storelli, FacundoMolina de la Torre, Antonio JoséZamora-Ros, RaulAragonès Sanz, NúriaAdarnaz, EvaCastaño-Vinyals, GemmaObón Santacana, MireiaGómez Acebo, InésMolina Barceló, AnaFernández Tardón, GuillermoJiménez Moleón, José JuanAlguacil, JuanChirlaque, María DoloresToledo Atucha, EstefaníaPérez Gómez, BeatrizPollán, MarinaKogevinas, ManolisMartín Sánchez, VicenteCàncer d'estómacNutricióEpidemiologiaStomach cancerNutritionEpidemiologySeveral anticancer properties have been largely attributed to phenolics in in vivo and in vitro studies, but epidemiologic evidence is still scarce. Furthermore, some classes have not been studied in relation to gastric cancer (GC). The aim of this study was to assess the relationship between the intake of phenolic acids, stilbenes, and other phenolics and the risk of developing GC and its anatomical and histological subtypes. We used data from a multi-case-control study (MCC-Spain) obtained from different regions of Spain. We included 2700 controls and 329 GC cases. Odds ratios (ORs) were calculated using mixed effects logistic regression considering quartiles of phenolic intake. Our results showed an inverse association between stilbene and lignan intake and GC risk (ORQ4 vs. Q1 = 0.47; 95% CI: 0.32-0.69 and ORQ4 vs. Q1 = 0.53; 95% CI: 0.36-0.77, respectively). We found no overall association between total phenolic acid and other polyphenol class intake and GC risk. However, hydroxybenzaldehydes (ORQ4 vs. Q1 = 0.41; 95% CI: 0.28-0.61), hydroxycoumarins (ORQ4 vs. Q1 = 0.49; 95% CI: 0.34-0.71), and tyrosols (ORQ4 vs. Q1 = 0.56; 95% CI: 0.39-0.80) were inversely associated with GC risk. No differences were found in the analysis by anatomical or histological subtypes. In conclusion, a diet high in stilbenes, lignans, hydroxybenzaldehydes, hydroxycoumarins, and tyrosols was associated with a lower GC risk. Further prospective studies are needed to confirm our results.MDPI2021202120202021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion16 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/173806Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/nu12113281Nutrients, 2020, vol. 12, num. 11https://doi.org/10.3390/nu12113281cc by (c) Rubín García et al., 2020http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1738062026-05-29T05:05:01Z
dc.title.none.fl_str_mv Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain
title Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain
spellingShingle Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain
Rubín García, María
Càncer d'estómac
Nutrició
Epidemiologia
Stomach cancer
Nutrition
Epidemiology
title_short Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain
title_full Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain
title_fullStr Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain
title_full_unstemmed Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain
title_sort Association between Polyphenol Intake and Gastric Cancer Risk by Anatomic and Histologic Subtypes: MCC-Spain
dc.creator.none.fl_str_mv Rubín García, María
Vitelli Storelli, Facundo
Molina de la Torre, Antonio José
Zamora-Ros, Raul
Aragonès Sanz, Núria
Adarnaz, Eva
Castaño-Vinyals, Gemma
Obón Santacana, Mireia
Gómez Acebo, Inés
Molina Barceló, Ana
Fernández Tardón, Guillermo
Jiménez Moleón, José Juan
Alguacil, Juan
Chirlaque, María Dolores
Toledo Atucha, Estefanía
Pérez Gómez, Beatriz
Pollán, Marina
Kogevinas, Manolis
Martín Sánchez, Vicente
author Rubín García, María
author_facet Rubín García, María
Vitelli Storelli, Facundo
Molina de la Torre, Antonio José
Zamora-Ros, Raul
Aragonès Sanz, Núria
Adarnaz, Eva
Castaño-Vinyals, Gemma
Obón Santacana, Mireia
Gómez Acebo, Inés
Molina Barceló, Ana
Fernández Tardón, Guillermo
Jiménez Moleón, José Juan
Alguacil, Juan
Chirlaque, María Dolores
Toledo Atucha, Estefanía
Pérez Gómez, Beatriz
Pollán, Marina
Kogevinas, Manolis
Martín Sánchez, Vicente
author_role author
author2 Vitelli Storelli, Facundo
Molina de la Torre, Antonio José
Zamora-Ros, Raul
Aragonès Sanz, Núria
Adarnaz, Eva
Castaño-Vinyals, Gemma
Obón Santacana, Mireia
Gómez Acebo, Inés
Molina Barceló, Ana
Fernández Tardón, Guillermo
Jiménez Moleón, José Juan
Alguacil, Juan
Chirlaque, María Dolores
Toledo Atucha, Estefanía
Pérez Gómez, Beatriz
Pollán, Marina
Kogevinas, Manolis
Martín Sánchez, Vicente
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer d'estómac
Nutrició
Epidemiologia
Stomach cancer
Nutrition
Epidemiology
topic Càncer d'estómac
Nutrició
Epidemiologia
Stomach cancer
Nutrition
Epidemiology
description Several anticancer properties have been largely attributed to phenolics in in vivo and in vitro studies, but epidemiologic evidence is still scarce. Furthermore, some classes have not been studied in relation to gastric cancer (GC). The aim of this study was to assess the relationship between the intake of phenolic acids, stilbenes, and other phenolics and the risk of developing GC and its anatomical and histological subtypes. We used data from a multi-case-control study (MCC-Spain) obtained from different regions of Spain. We included 2700 controls and 329 GC cases. Odds ratios (ORs) were calculated using mixed effects logistic regression considering quartiles of phenolic intake. Our results showed an inverse association between stilbene and lignan intake and GC risk (ORQ4 vs. Q1 = 0.47; 95% CI: 0.32-0.69 and ORQ4 vs. Q1 = 0.53; 95% CI: 0.36-0.77, respectively). We found no overall association between total phenolic acid and other polyphenol class intake and GC risk. However, hydroxybenzaldehydes (ORQ4 vs. Q1 = 0.41; 95% CI: 0.28-0.61), hydroxycoumarins (ORQ4 vs. Q1 = 0.49; 95% CI: 0.34-0.71), and tyrosols (ORQ4 vs. Q1 = 0.56; 95% CI: 0.39-0.80) were inversely associated with GC risk. No differences were found in the analysis by anatomical or histological subtypes. In conclusion, a diet high in stilbenes, lignans, hydroxybenzaldehydes, hydroxycoumarins, and tyrosols was associated with a lower GC risk. Further prospective studies are needed to confirm our results.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/173806
url https://hdl.handle.net/2445/173806
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/nu12113281
Nutrients, 2020, vol. 12, num. 11
https://doi.org/10.3390/nu12113281
dc.rights.none.fl_str_mv cc by (c) Rubín García et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Rubín García et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 16 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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