Gene expression changes elicited by a parasitic B chromosome in the grasshopper Eyprepocnemis plorans are consistent with its phenotypic effects

Parasitism evokes adaptive physiological changes in the host, many of which take place through gene expression changes. This response can be more or less local, depending on the organ or tissue affected by the parasite, or else systemic when the parasite affects the entire host body. The most extrem...

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Autores: Navarro-Domínguez, Beatriz, Martín-Peciña, María, Ruiz-Ruano, Francisco J., Cabrero, Josefa, Corral, José María, López-León, María Dolores, Sharbel, Timothy F., Camacho, Juan Pedro M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Jaén
Repositorio:RUJA. Repositorio Institucional de la Producción Científica de la Universidad de Jaén
OAI Identifier:oai:ruja.ujaen.es:10953/7308
Acceso en línea:https://doi.org/10.1007/s00412-018-00689-y
https://link.springer.com/article/10.1007/s00412-018-00689-y
https://hdl.handle.net/10953/7308
Access Level:acceso abierto
Palabra clave:B chromosome , Gene expression, Microarrays, qPCR, Transcriptome
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spelling Gene expression changes elicited by a parasitic B chromosome in the grasshopper Eyprepocnemis plorans are consistent with its phenotypic effectsNavarro-Domínguez, BeatrizMartín-Peciña, MaríaRuiz-Ruano, Francisco J.Cabrero, JosefaCorral, José MaríaLópez-León, María DoloresSharbel, Timothy F.Camacho, Juan Pedro M.B chromosome , Gene expression, Microarrays, qPCR, TranscriptomeB chromosome , Gene expression, Microarrays, qPCR, TranscriptomeParasitism evokes adaptive physiological changes in the host, many of which take place through gene expression changes. This response can be more or less local, depending on the organ or tissue affected by the parasite, or else systemic when the parasite affects the entire host body. The most extreme of the latter cases is intragenomic parasitism, where the parasite is present in all host nuclei as any other genomic element. Here, we show the molecular crosstalk between a parasitic chromosome (also named B chromosome) and the host genome, manifested through gene expression changes. The transcriptome analysis of 0B and 1B females of the grasshopper Eyprepocnemis plorans, validated by a microarray experiment performed on four B-lacking and five B-carrying females, revealed changes in gene expression for 188 unigenes being consistent in both experiments. Once discarded B-derived transcripts, there were 46 differentially expressed genes (30 up- and 16 downregulated) related with the adaptation of the host genome to the presence of the parasitic chromosome. Interestingly, the functions of these genes could explain some of the most important effects of B chromosomes, such as nucleotypic effects derived from the additional DNA they represent, chemical defense and detoxification, protein modification and response to stress, ovary function, and regulation of gene expression. Collectively, these changes uncover an intimate host-parasite interaction between A and B chromosomes during crucial steps of gene expression and protein function.Springer Nature202620262019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.1007/s00412-018-00689-yhttps://link.springer.com/article/10.1007/s00412-018-00689-yhttps://hdl.handle.net/10953/7308reponame:RUJA. Repositorio Institucional de la Producción Científica de la Universidad de Jaéninstname:Universidad de JaénInglésChromosomainfo:eu-repo/semantics/openAccessoai:ruja.ujaen.es:10953/73082026-06-24T12:41:07Z
dc.title.none.fl_str_mv Gene expression changes elicited by a parasitic B chromosome in the grasshopper Eyprepocnemis plorans are consistent with its phenotypic effects
title Gene expression changes elicited by a parasitic B chromosome in the grasshopper Eyprepocnemis plorans are consistent with its phenotypic effects
spellingShingle Gene expression changes elicited by a parasitic B chromosome in the grasshopper Eyprepocnemis plorans are consistent with its phenotypic effects
Navarro-Domínguez, Beatriz
B chromosome , Gene expression, Microarrays, qPCR, Transcriptome
B chromosome , Gene expression, Microarrays, qPCR, Transcriptome
title_short Gene expression changes elicited by a parasitic B chromosome in the grasshopper Eyprepocnemis plorans are consistent with its phenotypic effects
title_full Gene expression changes elicited by a parasitic B chromosome in the grasshopper Eyprepocnemis plorans are consistent with its phenotypic effects
title_fullStr Gene expression changes elicited by a parasitic B chromosome in the grasshopper Eyprepocnemis plorans are consistent with its phenotypic effects
title_full_unstemmed Gene expression changes elicited by a parasitic B chromosome in the grasshopper Eyprepocnemis plorans are consistent with its phenotypic effects
title_sort Gene expression changes elicited by a parasitic B chromosome in the grasshopper Eyprepocnemis plorans are consistent with its phenotypic effects
dc.creator.none.fl_str_mv Navarro-Domínguez, Beatriz
Martín-Peciña, María
Ruiz-Ruano, Francisco J.
Cabrero, Josefa
Corral, José María
López-León, María Dolores
Sharbel, Timothy F.
Camacho, Juan Pedro M.
author Navarro-Domínguez, Beatriz
author_facet Navarro-Domínguez, Beatriz
Martín-Peciña, María
Ruiz-Ruano, Francisco J.
Cabrero, Josefa
Corral, José María
López-León, María Dolores
Sharbel, Timothy F.
Camacho, Juan Pedro M.
author_role author
author2 Martín-Peciña, María
Ruiz-Ruano, Francisco J.
Cabrero, Josefa
Corral, José María
López-León, María Dolores
Sharbel, Timothy F.
Camacho, Juan Pedro M.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv B chromosome , Gene expression, Microarrays, qPCR, Transcriptome
B chromosome , Gene expression, Microarrays, qPCR, Transcriptome
topic B chromosome , Gene expression, Microarrays, qPCR, Transcriptome
B chromosome , Gene expression, Microarrays, qPCR, Transcriptome
description Parasitism evokes adaptive physiological changes in the host, many of which take place through gene expression changes. This response can be more or less local, depending on the organ or tissue affected by the parasite, or else systemic when the parasite affects the entire host body. The most extreme of the latter cases is intragenomic parasitism, where the parasite is present in all host nuclei as any other genomic element. Here, we show the molecular crosstalk between a parasitic chromosome (also named B chromosome) and the host genome, manifested through gene expression changes. The transcriptome analysis of 0B and 1B females of the grasshopper Eyprepocnemis plorans, validated by a microarray experiment performed on four B-lacking and five B-carrying females, revealed changes in gene expression for 188 unigenes being consistent in both experiments. Once discarded B-derived transcripts, there were 46 differentially expressed genes (30 up- and 16 downregulated) related with the adaptation of the host genome to the presence of the parasitic chromosome. Interestingly, the functions of these genes could explain some of the most important effects of B chromosomes, such as nucleotypic effects derived from the additional DNA they represent, chemical defense and detoxification, protein modification and response to stress, ovary function, and regulation of gene expression. Collectively, these changes uncover an intimate host-parasite interaction between A and B chromosomes during crucial steps of gene expression and protein function.
publishDate 2019
dc.date.none.fl_str_mv 2019
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1007/s00412-018-00689-y
https://link.springer.com/article/10.1007/s00412-018-00689-y
https://hdl.handle.net/10953/7308
url https://doi.org/10.1007/s00412-018-00689-y
https://link.springer.com/article/10.1007/s00412-018-00689-y
https://hdl.handle.net/10953/7308
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Chromosoma
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:RUJA. Repositorio Institucional de la Producción Científica de la Universidad de Jaén
instname:Universidad de Jaén
instname_str Universidad de Jaén
reponame_str RUJA. Repositorio Institucional de la Producción Científica de la Universidad de Jaén
collection RUJA. Repositorio Institucional de la Producción Científica de la Universidad de Jaén
repository.name.fl_str_mv
repository.mail.fl_str_mv
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