Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1

Hernández, Gonzalo; Ramírez, María José; Minguillón, Jordi; Quiles, Paco; Ruiz de Garibay, Gorka; Aza-Carmona, Miriam; Bogliolo, Massimo; Pujol, Roser; Prados-Carvajal, Rosario; Fernández, Juana; García, Nadia; López, Adrià; Gutiérrez-Enríquez, Sara; Diez, Orland; Benítez, Javier; Salinas, Mónica; Teulé, Alex; Brunet, Joan; Radice, Paolo; Peterlongo, Paolo; Schindler, Detlev; Huertas, Pablo; Puente, Xose S.; Lázaro, Conxi; Pujana, Miquel Àngel; Surrallés, Jordi

Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1

We thank Dr. Andre Nussenzweig and Dr. Elsa Callen for critical reading of the manuscript and helpful comments and Dr. Joaquin Dopazo for his help with the CIBERER Spanish Variant Server. Surrallés laboratory is supported by the ICREAAcademia program, the Marató de TV3 (project 464/C/2012), the Span...

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Autores:	Hernández, Gonzalo, Ramírez, María José, Minguillón, Jordi, Quiles, Paco, Ruiz de Garibay, Gorka, Aza-Carmona, Miriam, Bogliolo, Massimo, Pujol, Roser, Prados-Carvajal, Rosario, Fernández, Juana, García, Nadia, López, Adrià, Gutiérrez-Enríquez, Sara, Diez, Orland, Benítez, Javier, Salinas, Mónica, Teulé, Alex, Brunet, Joan, Radice, Paolo, Peterlongo, Paolo, Schindler, Detlev, Huertas, Pablo, Puente, Xose S., Lázaro, Conxi, Pujana, Miquel Àngel, Surrallés, Jordi
Tipo de recurso:	artículo
Fecha de publicación:	2018
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:20.500.12328/3946
Acceso en línea:	http://hdl.handle.net/20.500.12328/3946 https://dx.doi.org/10.1038/s41467-018-03433-3
Access Level:	acceso abierto
Palabra clave:	Càncer Inestabilitat genòmica Metabolisme de l'ARN Cancer Genomic instability RNA metabolism Cáncer Inestabilidad genómica Metabolismo del ARN 61

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network_acronym_str	ES
network_name_str	España
repository_id_str
dc.title.none.fl_str_mv	Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1
title	Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1
spellingShingle	Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1 Hernández, Gonzalo Càncer Inestabilitat genòmica Metabolisme de l'ARN Cancer Genomic instability RNA metabolism Cáncer Inestabilidad genómica Metabolismo del ARN 61
title_short	Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1
title_full	Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1
title_fullStr	Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1
title_full_unstemmed	Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1
title_sort	Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1
dc.creator.none.fl_str_mv	Hernández, Gonzalo Ramírez, María José Minguillón, Jordi Quiles, Paco Ruiz de Garibay, Gorka Aza-Carmona, Miriam Bogliolo, Massimo Pujol, Roser Prados-Carvajal, Rosario Fernández, Juana García, Nadia López, Adrià Gutiérrez-Enríquez, Sara Diez, Orland Benítez, Javier Salinas, Mónica Teulé, Alex Brunet, Joan Radice, Paolo Peterlongo, Paolo Schindler, Detlev Huertas, Pablo Puente, Xose S. Lázaro, Conxi Pujana, Miquel Àngel Surrallés, Jordi
author	Hernández, Gonzalo
author_facet	Hernández, Gonzalo Ramírez, María José Minguillón, Jordi Quiles, Paco Ruiz de Garibay, Gorka Aza-Carmona, Miriam Bogliolo, Massimo Pujol, Roser Prados-Carvajal, Rosario Fernández, Juana García, Nadia López, Adrià Gutiérrez-Enríquez, Sara Diez, Orland Benítez, Javier Salinas, Mónica Teulé, Alex Brunet, Joan Radice, Paolo Peterlongo, Paolo Schindler, Detlev Huertas, Pablo Puente, Xose S. Lázaro, Conxi Pujana, Miquel Àngel Surrallés, Jordi
author_role	author
author2	Ramírez, María José Minguillón, Jordi Quiles, Paco Ruiz de Garibay, Gorka Aza-Carmona, Miriam Bogliolo, Massimo Pujol, Roser Prados-Carvajal, Rosario Fernández, Juana García, Nadia López, Adrià Gutiérrez-Enríquez, Sara Diez, Orland Benítez, Javier Salinas, Mónica Teulé, Alex Brunet, Joan Radice, Paolo Peterlongo, Paolo Schindler, Detlev Huertas, Pablo Puente, Xose S. Lázaro, Conxi Pujana, Miquel Àngel Surrallés, Jordi
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Càncer Inestabilitat genòmica Metabolisme de l'ARN Cancer Genomic instability RNA metabolism Cáncer Inestabilidad genómica Metabolismo del ARN 61
topic	Càncer Inestabilitat genòmica Metabolisme de l'ARN Cancer Genomic instability RNA metabolism Cáncer Inestabilidad genómica Metabolismo del ARN 61
description	We thank Dr. Andre Nussenzweig and Dr. Elsa Callen for critical reading of the manuscript and helpful comments and Dr. Joaquin Dopazo for his help with the CIBERER Spanish Variant Server. Surrallés laboratory is supported by the ICREAAcademia program, the Marató de TV3 (project 464/C/2012), the Spanish Ministry of Health (projects FANCOSTEM and FANCOLEN), the Spanish Ministry of Economy and Competiveness (projects CB06/07/0023, SAF2012-31881, SAF2013-45836-R and SAF2015-64152-R), the European Commission (EUROFANCOLEN project HEALTHF5-2012-305421 and P-SPHERE COFUND project), the Fanconi Anemia Research Fund Inc., and the “Fondo Europeo de Desarrollo Regional, una manera de hacer Europa” (FEDER). CIBERER is an initiative of the Instituto de Salud Carlos III, Spain. This work was also supported by grants from the Asociación Española Contra el Cáncer (AECC, Hereditary Cancer group, 2010), the Generalitat de Catalunya (SGR 2014-364 and 2014-338), and the Instituto de Salud Carlos III (PIE13/00022-ONCOPROFILE, CP10/00617, PI10/01422, PI12/02585, PI13/00285, PI15/00854, PI16/00563, PI16/01218, and RTICC RD12/0036/0008). S.G.-E. is funded by a Miguel Servet contract from the Instituto de Salud Carlos III.
publishDate	2018
dc.date.none.fl_str_mv	2018
dc.type.none.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	http://hdl.handle.net/20.500.12328/3946 https://dx.doi.org/10.1038/s41467-018-03433-3
url	http://hdl.handle.net/20.500.12328/3946 https://dx.doi.org/10.1038/s41467-018-03433-3
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Nature Communications 9 info:eu-repo/grantAgreement/ES/MINECO/SAF2012-31881 info:eu-repo/grantAgreement/ES/MINECO/SAF2013-45836-R info:eu-repo/grantAgreement/ES/MINECO/SAF2015-64152-R
dc.rights.none.fl_str_mv	http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	11
dc.publisher.none.fl_str_mv	Springer Nature
publisher.none.fl_str_mv	Springer Nature
dc.source.none.fl_str_mv	reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
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spelling	Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1Hernández, GonzaloRamírez, María JoséMinguillón, JordiQuiles, PacoRuiz de Garibay, GorkaAza-Carmona, MiriamBogliolo, MassimoPujol, RoserPrados-Carvajal, RosarioFernández, JuanaGarcía, NadiaLópez, AdriàGutiérrez-Enríquez, SaraDiez, OrlandBenítez, JavierSalinas, MónicaTeulé, AlexBrunet, JoanRadice, PaoloPeterlongo, PaoloSchindler, DetlevHuertas, PabloPuente, Xose S.Lázaro, ConxiPujana, Miquel ÀngelSurrallés, JordiCàncerInestabilitat genòmicaMetabolisme de l'ARNCancerGenomic instabilityRNA metabolismCáncerInestabilidad genómicaMetabolismo del ARN61We thank Dr. Andre Nussenzweig and Dr. Elsa Callen for critical reading of the manuscript and helpful comments and Dr. Joaquin Dopazo for his help with the CIBERER Spanish Variant Server. Surrallés laboratory is supported by the ICREAAcademia program, the Marató de TV3 (project 464/C/2012), the Spanish Ministry of Health (projects FANCOSTEM and FANCOLEN), the Spanish Ministry of Economy and Competiveness (projects CB06/07/0023, SAF2012-31881, SAF2013-45836-R and SAF2015-64152-R), the European Commission (EUROFANCOLEN project HEALTHF5-2012-305421 and P-SPHERE COFUND project), the Fanconi Anemia Research Fund Inc., and the “Fondo Europeo de Desarrollo Regional, una manera de hacer Europa” (FEDER). CIBERER is an initiative of the Instituto de Salud Carlos III, Spain. This work was also supported by grants from the Asociación Española Contra el Cáncer (AECC, Hereditary Cancer group, 2010), the Generalitat de Catalunya (SGR 2014-364 and 2014-338), and the Instituto de Salud Carlos III (PIE13/00022-ONCOPROFILE, CP10/00617, PI10/01422, PI12/02585, PI13/00285, PI15/00854, PI16/00563, PI16/01218, and RTICC RD12/0036/0008). S.G.-E. is funded by a Miguel Servet contract from the Instituto de Salud Carlos III.BRCA1 is a tumor suppressor that regulates DNA repair by homologous recombination. Germline mutations in BRCA1 are associated with increased risk of breast and ovarian cancer and BRCA1 deficient tumors are exquisitely sensitive to poly (ADP-ribose) polymerase (PARP) inhibitors. Therefore, uncovering additional components of this DNA repair pathway is of extreme importance for further understanding cancer development and therapeutic vulnerabilities. Here, we identify EDC4, a known component of processing-bodies and regulator of mRNA decapping, as a member of the BRCA1-BRIP1-TOPBP1 complex. EDC4 plays a key role in homologous recombination by stimulating end resection at double-strand breaks. EDC4 deficiency leads to genome instability and hypersensitivity to DNA interstrand cross-linking drugs and PARP inhibitors. Lack-of-function mutations in EDC4 were detected in BRCA1/2-mutation-negative breast cancer cases, suggesting a role in breast cancer susceptibility. Collectively, this study recognizes EDC4 with a dual role in decapping and DNA repair whose inactivation phenocopies BRCA1 deficiency.info:eu-repo/semantics/publishedVersionSpringer Nature2018info:eu-repo/semantics/article11http://hdl.handle.net/20.500.12328/3946https://dx.doi.org/10.1038/s41467-018-03433-3reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésNature Communications9info:eu-repo/grantAgreement/ES/MINECO/SAF2012-31881info:eu-repo/grantAgreement/ES/MINECO/SAF2013-45836-Rinfo:eu-repo/grantAgreement/ES/MINECO/SAF2015-64152-RThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12328/39462026-05-29T05:05:01Z
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Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1

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