Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study

Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated...

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Detalles Bibliográficos
Autores: de Rojas, Itziar, Hernández, Isabel, Montrreal, Laura, Quintela, Inés, Calero, Miguel, Royo Sánchez-Palencia, José Luis, Huerto Vilas, Raquel, González Pérez, Antonio, Franco Macías, Emilio, Macías, Juan, Menéndez González, Manuel, Frank García, Ana, Diez Fairen, Mónica, Lage, Carmen, García Madrona, Sebastián, Aguilera, Nuria, García González, Pablo, Puerta, Raquel, Sotolongo Grau, Oscar, Alonso Lana, Silvia, Rábano, Alberto, Arias Pastor, Alfonso, Pastor, Ana Belén, Corma Gómez, Anaïs, Martín Montes, Ángel, Martínez Rodríguez, Carmen, Buiza Rueda, Dolores, Rodríguez Rodríguez, Eloy, Álvarez, Ignacio, Rosas Allende, Irene, Pineda, Juan A., Bernal Sánchez-Arjona, María, Fernández Fuertes, Marta, Mendoza, Silvia, Del Ser, Teodoro, García Ribas, Guillermo, Sánchez Juan, Pascual, Pastor, Pau, Bullido, María J., Álvarez, Victoria, Real, Luis M., Mir, Pablo, Piñol Ripoll, Gerard, García Alberca, Jose María, Medina, Miguel, Orellana, Adelina, Butler, Chris R., Marquié, Marta, Sáez, María Eugenia, Carracedo, Angel, Tárraga, Lluís, Boada, Mercè, Ruiz, Agustín
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/73447
Acceso en línea:https://doi.org/10.3390/jpm11121318
http://hdl.handle.net/10459.1/73447
Access Level:acceso abierto
Palabra clave:APOE
COVID-19
GR@ACE/DEGESCO
GWAS
SARS-CoV-2
Dementia
Descripción
Sumario:Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the APOE locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (LZTFL1, SLC6A20) implicated in the susceptibility to SARS-CoV-2 infection and TYK2 gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the APOE locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis.

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