Intermittent inotropic support with levosimendan in advanced heart failure as destination therapy
Patients with advanced heart failure (AHF) who are not candidates to advanced therapies have poor prognosis. Some trials have shown that intermittent levosimendan can reduce HF hospitalizations in AHF in the short term. In this real-life registry, we describe the patterns of use, safety and factors...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:301691 |
| Acceso en línea: | https://ddd.uab.cat/record/301691 https://dx.doi.org/urn:doi:10.1002/ehf2.14278 |
| Access Level: | acceso abierto |
| Palabra clave: | Advanced heart failure Inotropes Levosimendan Palliative care |
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Intermittent inotropic support with levosimendan in advanced heart failure as destination therapyThe LEVO-D registryDobarro, David|||0000-0003-0716-254XDonoso-Trenado, VíctorSolé González, Eduard|||0000-0002-5727-9925Moliner-Abós, Carles|||0000-0002-9264-5804García Pinilla, José Manuel|||0000-0001-5999-5741Lopez-Fernandez, Silvia|||0000-0002-2461-8492Ruiz Bustillo, Sonia|||0000-0002-6074-914XDíez-López, Carles|||0000-0002-3734-4777Castrodeza, Javier|||0000-0002-4779-6849Méndez-Fernández, Ana B.Vaqueriza-Cubillo, David|||0000-0002-8207-7604Cobo-Marcos, M.|||0000-0002-9026-061XTobar, JavierSagasti-Aboitiz, IgorRodriguez, MiguelEscolar, VanessaAbecia, AnaCodina, Pau|||0000-0002-2469-5711Gómez-Otero, InésPastor, Francisco|||0000-0002-9818-2409Marzoa-Rivas, RaquelGonzález-Babarro, Evade Juan-Baguda, JavierMelendo-Viu, MaríaDe Frutos, Fernando|||0000-0003-4350-3217González-Costello, José|||0000-0002-7437-3630Advanced heart failureInotropesLevosimendanPalliative carePatients with advanced heart failure (AHF) who are not candidates to advanced therapies have poor prognosis. Some trials have shown that intermittent levosimendan can reduce HF hospitalizations in AHF in the short term. In this real-life registry, we describe the patterns of use, safety and factors related to the response to intermittent levosimendan infusions in AHF patients not candidates to advanced therapies. Multicentre retrospective study of patients diagnosed with advanced heart failure, not HT or LVAD candidates. Patients needed to be on the optimal medical therapy according to their treating physician. Patients with de novo heart failure or who underwent any procedure that could improve prognosis were not included in the registry. Four hundred three patients were included; 77.9% needed at least one admission the year before levosimendan was first administered because of heart failure. Death rate at 1 year was 26.8% and median survival was 24.7 [95% CI: 20.4-26.9] months, and 43.7% of patients fulfilled the criteria for being considered a responder lo levosimendan (no death, heart failure admission or unplanned HF visit at 1 year after first levosimendan administration). Compared with the year before there was a significant reduction in HF admissions (38.7% vs. 77.9%; P < 0.0001), unplanned HF visits (22.7% vs. 43.7%; P < 0.0001) or the combined event including deaths (56.3% vs. 81.4%; P < 0.0001) during the year after. We created a score that helps predicting the responder status at 1 year after levosimendan, resulting in a score summatory of five variables: TEER (+2), treatment with beta-blockers (+1.5), Haemoglobin.Universitat Autònoma de Barcelona 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/301691https://dx.doi.org/urn:doi:10.1002/ehf2.14278reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3016912026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Intermittent inotropic support with levosimendan in advanced heart failure as destination therapy The LEVO-D registry |
| title |
Intermittent inotropic support with levosimendan in advanced heart failure as destination therapy |
| spellingShingle |
Intermittent inotropic support with levosimendan in advanced heart failure as destination therapy Dobarro, David|||0000-0003-0716-254X Advanced heart failure Inotropes Levosimendan Palliative care |
| title_short |
Intermittent inotropic support with levosimendan in advanced heart failure as destination therapy |
| title_full |
Intermittent inotropic support with levosimendan in advanced heart failure as destination therapy |
| title_fullStr |
Intermittent inotropic support with levosimendan in advanced heart failure as destination therapy |
| title_full_unstemmed |
Intermittent inotropic support with levosimendan in advanced heart failure as destination therapy |
| title_sort |
Intermittent inotropic support with levosimendan in advanced heart failure as destination therapy |
| dc.creator.none.fl_str_mv |
Dobarro, David|||0000-0003-0716-254X Donoso-Trenado, Víctor Solé González, Eduard|||0000-0002-5727-9925 Moliner-Abós, Carles|||0000-0002-9264-5804 García Pinilla, José Manuel|||0000-0001-5999-5741 Lopez-Fernandez, Silvia|||0000-0002-2461-8492 Ruiz Bustillo, Sonia|||0000-0002-6074-914X Díez-López, Carles|||0000-0002-3734-4777 Castrodeza, Javier|||0000-0002-4779-6849 Méndez-Fernández, Ana B. Vaqueriza-Cubillo, David|||0000-0002-8207-7604 Cobo-Marcos, M.|||0000-0002-9026-061X Tobar, Javier Sagasti-Aboitiz, Igor Rodriguez, Miguel Escolar, Vanessa Abecia, Ana Codina, Pau|||0000-0002-2469-5711 Gómez-Otero, Inés Pastor, Francisco|||0000-0002-9818-2409 Marzoa-Rivas, Raquel González-Babarro, Eva de Juan-Baguda, Javier Melendo-Viu, María De Frutos, Fernando|||0000-0003-4350-3217 González-Costello, José|||0000-0002-7437-3630 |
| author |
Dobarro, David|||0000-0003-0716-254X |
| author_facet |
Dobarro, David|||0000-0003-0716-254X Donoso-Trenado, Víctor Solé González, Eduard|||0000-0002-5727-9925 Moliner-Abós, Carles|||0000-0002-9264-5804 García Pinilla, José Manuel|||0000-0001-5999-5741 Lopez-Fernandez, Silvia|||0000-0002-2461-8492 Ruiz Bustillo, Sonia|||0000-0002-6074-914X Díez-López, Carles|||0000-0002-3734-4777 Castrodeza, Javier|||0000-0002-4779-6849 Méndez-Fernández, Ana B. Vaqueriza-Cubillo, David|||0000-0002-8207-7604 Cobo-Marcos, M.|||0000-0002-9026-061X Tobar, Javier Sagasti-Aboitiz, Igor Rodriguez, Miguel Escolar, Vanessa Abecia, Ana Codina, Pau|||0000-0002-2469-5711 Gómez-Otero, Inés Pastor, Francisco|||0000-0002-9818-2409 Marzoa-Rivas, Raquel González-Babarro, Eva de Juan-Baguda, Javier Melendo-Viu, María De Frutos, Fernando|||0000-0003-4350-3217 González-Costello, José|||0000-0002-7437-3630 |
| author_role |
author |
| author2 |
Donoso-Trenado, Víctor Solé González, Eduard|||0000-0002-5727-9925 Moliner-Abós, Carles|||0000-0002-9264-5804 García Pinilla, José Manuel|||0000-0001-5999-5741 Lopez-Fernandez, Silvia|||0000-0002-2461-8492 Ruiz Bustillo, Sonia|||0000-0002-6074-914X Díez-López, Carles|||0000-0002-3734-4777 Castrodeza, Javier|||0000-0002-4779-6849 Méndez-Fernández, Ana B. Vaqueriza-Cubillo, David|||0000-0002-8207-7604 Cobo-Marcos, M.|||0000-0002-9026-061X Tobar, Javier Sagasti-Aboitiz, Igor Rodriguez, Miguel Escolar, Vanessa Abecia, Ana Codina, Pau|||0000-0002-2469-5711 Gómez-Otero, Inés Pastor, Francisco|||0000-0002-9818-2409 Marzoa-Rivas, Raquel González-Babarro, Eva de Juan-Baguda, Javier Melendo-Viu, María De Frutos, Fernando|||0000-0003-4350-3217 González-Costello, José|||0000-0002-7437-3630 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Advanced heart failure Inotropes Levosimendan Palliative care |
| topic |
Advanced heart failure Inotropes Levosimendan Palliative care |
| description |
Patients with advanced heart failure (AHF) who are not candidates to advanced therapies have poor prognosis. Some trials have shown that intermittent levosimendan can reduce HF hospitalizations in AHF in the short term. In this real-life registry, we describe the patterns of use, safety and factors related to the response to intermittent levosimendan infusions in AHF patients not candidates to advanced therapies. Multicentre retrospective study of patients diagnosed with advanced heart failure, not HT or LVAD candidates. Patients needed to be on the optimal medical therapy according to their treating physician. Patients with de novo heart failure or who underwent any procedure that could improve prognosis were not included in the registry. Four hundred three patients were included; 77.9% needed at least one admission the year before levosimendan was first administered because of heart failure. Death rate at 1 year was 26.8% and median survival was 24.7 [95% CI: 20.4-26.9] months, and 43.7% of patients fulfilled the criteria for being considered a responder lo levosimendan (no death, heart failure admission or unplanned HF visit at 1 year after first levosimendan administration). Compared with the year before there was a significant reduction in HF admissions (38.7% vs. 77.9%; P < 0.0001), unplanned HF visits (22.7% vs. 43.7%; P < 0.0001) or the combined event including deaths (56.3% vs. 81.4%; P < 0.0001) during the year after. We created a score that helps predicting the responder status at 1 year after levosimendan, resulting in a score summatory of five variables: TEER (+2), treatment with beta-blockers (+1.5), Haemoglobin. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2 2023-01-01 2023 2023-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/301691 https://dx.doi.org/urn:doi:10.1002/ehf2.14278 |
| url |
https://ddd.uab.cat/record/301691 https://dx.doi.org/urn:doi:10.1002/ehf2.14278 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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