Photodithazine-mediated antimicrobial photodynamic therapy: a systematic review of efficacy and applications

Antimicrobial resistance is a critical global health issue exacerbated by biofilm-associated infections that often resist conventional therapies. Photodithazine-mediated antimicrobial photodynamic therapy (PDZ-aPDT) has emerged as a promising alternative, demonstrating a broad-spectrum antimicrobial...

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Autores: Wiench, Rafal, Fiegler-Rudol, Jakub, Grzech-Leśniak, Kinga, Skaba, Dariusz, Arnabat Domínguez, Josep
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/223139
Acceso en línea:https://hdl.handle.net/2445/223139
Access Level:acceso abierto
Palabra clave:Medicaments antiinfecciosos
Animals
Biofilms
Fotoquimioteràpia
Anti-infective agents
Photochemotherapy
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spelling Photodithazine-mediated antimicrobial photodynamic therapy: a systematic review of efficacy and applicationsWiench, RafalFiegler-Rudol, JakubGrzech-Leśniak, KingaSkaba, DariuszArnabat Domínguez, JosepMedicaments antiinfecciososAnimalsBiofilmsFotoquimioteràpiaAnti-infective agentsAnimalsBiofilmsPhotochemotherapyAntimicrobial resistance is a critical global health issue exacerbated by biofilm-associated infections that often resist conventional therapies. Photodithazine-mediated antimicrobial photodynamic therapy (PDZ-aPDT) has emerged as a promising alternative, demonstrating a broad-spectrum antimicrobial efficacy against multidrug-resistant bacteria and fungi, including those in biofilms. This systematic review evaluates the efficacy, safety, and clinical applications of PDZ-aPDT by synthesizing evidence from preclinical and clinical studies. Databases including PubMed, Embase, Scopus, and Cochrane were systematically searched, resulting in the inclusion of 13 studies for qualitative analysis. PDZ-aPDT consistently reduced the microbial burden in various models, including oral candidiasis, denture stomatitis, acne, and infections related to medical devices. Synergistic combinations with conventional antimicrobials and adjunctive therapies (e.g., DNase I) further enhanced its effectiveness. However, the evidence base remains limited by methodological variability, small sample sizes, and short follow-up periods. Future research should focus on rigorous clinical trials with standardized protocols and extended follow-up to establish definitive efficacy and safety profiles, facilitating a broader clinical implementation in combating antimicrobial resistance.MDPI2025202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion22 p.application/pdfhttps://hdl.handle.net/2445/223139Articles publicats en revistes (Odontoestomatologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/ijms26168049International Journal of Molecular Sciences, 2025, vol. 26, num.16https://doi.org/10.3390/ijms26168049cc-by (c) Wiench, R. et al., 2025http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2231392026-05-29T05:05:01Z
dc.title.none.fl_str_mv Photodithazine-mediated antimicrobial photodynamic therapy: a systematic review of efficacy and applications
title Photodithazine-mediated antimicrobial photodynamic therapy: a systematic review of efficacy and applications
spellingShingle Photodithazine-mediated antimicrobial photodynamic therapy: a systematic review of efficacy and applications
Wiench, Rafal
Medicaments antiinfecciosos
Animals
Biofilms
Fotoquimioteràpia
Anti-infective agents
Animals
Biofilms
Photochemotherapy
title_short Photodithazine-mediated antimicrobial photodynamic therapy: a systematic review of efficacy and applications
title_full Photodithazine-mediated antimicrobial photodynamic therapy: a systematic review of efficacy and applications
title_fullStr Photodithazine-mediated antimicrobial photodynamic therapy: a systematic review of efficacy and applications
title_full_unstemmed Photodithazine-mediated antimicrobial photodynamic therapy: a systematic review of efficacy and applications
title_sort Photodithazine-mediated antimicrobial photodynamic therapy: a systematic review of efficacy and applications
dc.creator.none.fl_str_mv Wiench, Rafal
Fiegler-Rudol, Jakub
Grzech-Leśniak, Kinga
Skaba, Dariusz
Arnabat Domínguez, Josep
author Wiench, Rafal
author_facet Wiench, Rafal
Fiegler-Rudol, Jakub
Grzech-Leśniak, Kinga
Skaba, Dariusz
Arnabat Domínguez, Josep
author_role author
author2 Fiegler-Rudol, Jakub
Grzech-Leśniak, Kinga
Skaba, Dariusz
Arnabat Domínguez, Josep
author2_role author
author
author
author
dc.subject.none.fl_str_mv Medicaments antiinfecciosos
Animals
Biofilms
Fotoquimioteràpia
Anti-infective agents
Animals
Biofilms
Photochemotherapy
topic Medicaments antiinfecciosos
Animals
Biofilms
Fotoquimioteràpia
Anti-infective agents
Animals
Biofilms
Photochemotherapy
description Antimicrobial resistance is a critical global health issue exacerbated by biofilm-associated infections that often resist conventional therapies. Photodithazine-mediated antimicrobial photodynamic therapy (PDZ-aPDT) has emerged as a promising alternative, demonstrating a broad-spectrum antimicrobial efficacy against multidrug-resistant bacteria and fungi, including those in biofilms. This systematic review evaluates the efficacy, safety, and clinical applications of PDZ-aPDT by synthesizing evidence from preclinical and clinical studies. Databases including PubMed, Embase, Scopus, and Cochrane were systematically searched, resulting in the inclusion of 13 studies for qualitative analysis. PDZ-aPDT consistently reduced the microbial burden in various models, including oral candidiasis, denture stomatitis, acne, and infections related to medical devices. Synergistic combinations with conventional antimicrobials and adjunctive therapies (e.g., DNase I) further enhanced its effectiveness. However, the evidence base remains limited by methodological variability, small sample sizes, and short follow-up periods. Future research should focus on rigorous clinical trials with standardized protocols and extended follow-up to establish definitive efficacy and safety profiles, facilitating a broader clinical implementation in combating antimicrobial resistance.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/223139
url https://hdl.handle.net/2445/223139
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/ijms26168049
International Journal of Molecular Sciences, 2025, vol. 26, num.16
https://doi.org/10.3390/ijms26168049
dc.rights.none.fl_str_mv cc-by (c) Wiench, R. et al., 2025
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Wiench, R. et al., 2025
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 22 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Odontoestomatologia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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