Progression of cortical thinning in early Parkinson's disease

The aim of this study was to investigate the progression of cortical thinning and gray-matter (GM) volume loss in early Parkinson's disease (PD). MRI and neuropsychological assessment were obtained at baseline and follow-up (mean ± standard deviation = 35.50 ± 1.88 months) in a group of 16 earl...

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Autores: Ibarretxe Bilbao, Naroa, Junqué i Plaja, Carme, 1955-, Segura i Fàbregas, Bàrbara, Baggio, Hugo César, Martí Domènech, Ma. Josep, Valldeoriola Serra, Francesc, Bargalló Alabart, Núria, Tolosa, Eduardo
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2012
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/161637
Acceso en línea:https://hdl.handle.net/2445/161637
Access Level:acceso abierto
Palabra clave:Imatges per ressonància magnètica
Escorça cerebral
Malaltia de Parkinson
Magnetic resonance imaging
Cerebral cortex
Parkinson's disease
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spelling Progression of cortical thinning in early Parkinson's diseaseIbarretxe Bilbao, NaroaJunqué i Plaja, Carme, 1955-Segura i Fàbregas, BàrbaraBaggio, Hugo CésarMartí Domènech, Ma. JosepValldeoriola Serra, FrancescBargalló Alabart, NúriaTolosa, EduardoImatges per ressonància magnèticaEscorça cerebralMalaltia de ParkinsonMagnetic resonance imagingCerebral cortexParkinson's diseaseThe aim of this study was to investigate the progression of cortical thinning and gray-matter (GM) volume loss in early Parkinson's disease (PD). MRI and neuropsychological assessment were obtained at baseline and follow-up (mean ± standard deviation = 35.50 ± 1.88 months) in a group of 16 early-PD patients (H & Y stage ≤II and disease duration ≤5 years) and 15 healthy controls matched for age, gender, and years of education. FreeSurfer software was used for the analysis of cortical thickness as well as for cortical and subcortical volumetric analyses. Voxel-based morphometry analysis was performed using SPM8. Compared to controls, PD patients showed greater regional cortical thinning in bilateral frontotemporal regions as well as greater over-time total GM loss and amygdalar volume reduction. PD patients and controls presented similar over-time changes in cognitive functioning. In early-PD patients, global GM loss, amygdalar atrophy, and cortical thinning in frontotemporal regions are specifically associated with the PD-degenerative process.Wiley2020202020122020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion25 p.application/pdfhttps://hdl.handle.net/2445/161637Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1002/mds.25240Movement Disorders, 2012, vol. 27, num. 14, p. 1746-1753https://doi.org/10.1002/mds.25240(c) International Parkinson and Movement Disorder Society, 2012info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1616372026-05-29T05:05:01Z
dc.title.none.fl_str_mv Progression of cortical thinning in early Parkinson's disease
title Progression of cortical thinning in early Parkinson's disease
spellingShingle Progression of cortical thinning in early Parkinson's disease
Ibarretxe Bilbao, Naroa
Imatges per ressonància magnètica
Escorça cerebral
Malaltia de Parkinson
Magnetic resonance imaging
Cerebral cortex
Parkinson's disease
title_short Progression of cortical thinning in early Parkinson's disease
title_full Progression of cortical thinning in early Parkinson's disease
title_fullStr Progression of cortical thinning in early Parkinson's disease
title_full_unstemmed Progression of cortical thinning in early Parkinson's disease
title_sort Progression of cortical thinning in early Parkinson's disease
dc.creator.none.fl_str_mv Ibarretxe Bilbao, Naroa
Junqué i Plaja, Carme, 1955-
Segura i Fàbregas, Bàrbara
Baggio, Hugo César
Martí Domènech, Ma. Josep
Valldeoriola Serra, Francesc
Bargalló Alabart, Núria
Tolosa, Eduardo
author Ibarretxe Bilbao, Naroa
author_facet Ibarretxe Bilbao, Naroa
Junqué i Plaja, Carme, 1955-
Segura i Fàbregas, Bàrbara
Baggio, Hugo César
Martí Domènech, Ma. Josep
Valldeoriola Serra, Francesc
Bargalló Alabart, Núria
Tolosa, Eduardo
author_role author
author2 Junqué i Plaja, Carme, 1955-
Segura i Fàbregas, Bàrbara
Baggio, Hugo César
Martí Domènech, Ma. Josep
Valldeoriola Serra, Francesc
Bargalló Alabart, Núria
Tolosa, Eduardo
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Imatges per ressonància magnètica
Escorça cerebral
Malaltia de Parkinson
Magnetic resonance imaging
Cerebral cortex
Parkinson's disease
topic Imatges per ressonància magnètica
Escorça cerebral
Malaltia de Parkinson
Magnetic resonance imaging
Cerebral cortex
Parkinson's disease
description The aim of this study was to investigate the progression of cortical thinning and gray-matter (GM) volume loss in early Parkinson's disease (PD). MRI and neuropsychological assessment were obtained at baseline and follow-up (mean ± standard deviation = 35.50 ± 1.88 months) in a group of 16 early-PD patients (H & Y stage ≤II and disease duration ≤5 years) and 15 healthy controls matched for age, gender, and years of education. FreeSurfer software was used for the analysis of cortical thickness as well as for cortical and subcortical volumetric analyses. Voxel-based morphometry analysis was performed using SPM8. Compared to controls, PD patients showed greater regional cortical thinning in bilateral frontotemporal regions as well as greater over-time total GM loss and amygdalar volume reduction. PD patients and controls presented similar over-time changes in cognitive functioning. In early-PD patients, global GM loss, amygdalar atrophy, and cortical thinning in frontotemporal regions are specifically associated with the PD-degenerative process.
publishDate 2012
dc.date.none.fl_str_mv 2012
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/161637
url https://hdl.handle.net/2445/161637
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1002/mds.25240
Movement Disorders, 2012, vol. 27, num. 14, p. 1746-1753
https://doi.org/10.1002/mds.25240
dc.rights.none.fl_str_mv (c) International Parkinson and Movement Disorder Society, 2012
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) International Parkinson and Movement Disorder Society, 2012
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 25 p.
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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