Antioxidant efficacy and “In Vivo” safety of a bentonite/vitamin C hybrid

L-ascorbic acid (LAA), commonly known as vitamin C, is an excellent and recognized antioxidant molecule used in pharmaceutical and cosmetic formulations. Several strategies have been developed in order to preserve its chemical stability, connected with its antioxidant power, but there is little rese...

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Autores: Hernández, Dayaris, Montalvo, Anaela, Pérez, Irela, Charnay, Clarence, Sánchez Espejo, Rita, Cerezo, Pilar, Viseras, César, Riela, Serena, Cinà, Giuseppe, Rivera, Aramis
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/342568
Acesso em linha:http://hdl.handle.net/10261/342568
Access Level:acceso abierto
Palavra-chave:Bentonite
L-ascorbic acid
Antioxidant capacity
Photoprotection
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spelling Antioxidant efficacy and “In Vivo” safety of a bentonite/vitamin C hybridHernández, DayarisMontalvo, AnaelaPérez, IrelaCharnay, ClarenceSánchez Espejo, RitaCerezo, PilarViseras, CésarRiela, SerenaCinà, GiuseppeRivera, AramisBentoniteL-ascorbic acidAntioxidant capacityPhotoprotectionL-ascorbic acid (LAA), commonly known as vitamin C, is an excellent and recognized antioxidant molecule used in pharmaceutical and cosmetic formulations. Several strategies have been developed in order to preserve its chemical stability, connected with its antioxidant power, but there is little research regarding the employment of natural clays as LAA host. A safe bentonite (Bent)—which was verified by in vivo ophthalmic irritability and acute dermal toxicity assays—was used as carrier of LAA. The supramolecular complex between LAA and clay may constitute an excellent alternative, since the molecule integrity does not seem to be affected, at least from the point of view of its antioxidant capacity. The Bent/LAA hybrid was prepared and characterized through ultraviolet (UV) spectroscopy, X-ray diffraction (XRD), infrared (IR) spectroscopy, thermogravimetric analysis (TG/DTG) and zeta potential measurements. Photostability and antioxidant capacity tests were also performed. The LAA incorporation into Bent clay was demonstrated, as well as the drug stability due to the Bent photoprotective effect onto the LAA molecule. Moreover, the antioxidant capacity of the drug in the Bent/LAA composite was confirmed.We acknowledge the National Research Projects PN211LH008-027 and PN223LH010-017Multidisciplinary Digital Publishing InstituteConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2024202420232024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/342568reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.3390/pharmaceutics15041171Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3425682026-05-22T06:33:51Z
dc.title.none.fl_str_mv Antioxidant efficacy and “In Vivo” safety of a bentonite/vitamin C hybrid
title Antioxidant efficacy and “In Vivo” safety of a bentonite/vitamin C hybrid
spellingShingle Antioxidant efficacy and “In Vivo” safety of a bentonite/vitamin C hybrid
Hernández, Dayaris
Bentonite
L-ascorbic acid
Antioxidant capacity
Photoprotection
title_short Antioxidant efficacy and “In Vivo” safety of a bentonite/vitamin C hybrid
title_full Antioxidant efficacy and “In Vivo” safety of a bentonite/vitamin C hybrid
title_fullStr Antioxidant efficacy and “In Vivo” safety of a bentonite/vitamin C hybrid
title_full_unstemmed Antioxidant efficacy and “In Vivo” safety of a bentonite/vitamin C hybrid
title_sort Antioxidant efficacy and “In Vivo” safety of a bentonite/vitamin C hybrid
dc.creator.none.fl_str_mv Hernández, Dayaris
Montalvo, Anaela
Pérez, Irela
Charnay, Clarence
Sánchez Espejo, Rita
Cerezo, Pilar
Viseras, César
Riela, Serena
Cinà, Giuseppe
Rivera, Aramis
author Hernández, Dayaris
author_facet Hernández, Dayaris
Montalvo, Anaela
Pérez, Irela
Charnay, Clarence
Sánchez Espejo, Rita
Cerezo, Pilar
Viseras, César
Riela, Serena
Cinà, Giuseppe
Rivera, Aramis
author_role author
author2 Montalvo, Anaela
Pérez, Irela
Charnay, Clarence
Sánchez Espejo, Rita
Cerezo, Pilar
Viseras, César
Riela, Serena
Cinà, Giuseppe
Rivera, Aramis
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Bentonite
L-ascorbic acid
Antioxidant capacity
Photoprotection
topic Bentonite
L-ascorbic acid
Antioxidant capacity
Photoprotection
description L-ascorbic acid (LAA), commonly known as vitamin C, is an excellent and recognized antioxidant molecule used in pharmaceutical and cosmetic formulations. Several strategies have been developed in order to preserve its chemical stability, connected with its antioxidant power, but there is little research regarding the employment of natural clays as LAA host. A safe bentonite (Bent)—which was verified by in vivo ophthalmic irritability and acute dermal toxicity assays—was used as carrier of LAA. The supramolecular complex between LAA and clay may constitute an excellent alternative, since the molecule integrity does not seem to be affected, at least from the point of view of its antioxidant capacity. The Bent/LAA hybrid was prepared and characterized through ultraviolet (UV) spectroscopy, X-ray diffraction (XRD), infrared (IR) spectroscopy, thermogravimetric analysis (TG/DTG) and zeta potential measurements. Photostability and antioxidant capacity tests were also performed. The LAA incorporation into Bent clay was demonstrated, as well as the drug stability due to the Bent photoprotective effect onto the LAA molecule. Moreover, the antioxidant capacity of the drug in the Bent/LAA composite was confirmed.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/342568
url http://hdl.handle.net/10261/342568
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.3390/pharmaceutics15041171
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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