New Insights Into the Role of Qa-2 and HLA-G Non-classical MHC-I Complexes in Malignancy

It is well established that the immune system can identify and destroy neoplastic transformed cells in a process known as immunosurveillance. Most studies have focused on the classical major histocompatibility complex (MHC) class Ia molecules, which are known to play an important role on the present...

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Detalles Bibliográficos
Autores: Da Silva, Istéfani L., Montero-Montero, Lucía, Ferreira, Enio, Quintanilla, Miguel
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/688174
Acceso en línea:http://hdl.handle.net/10486/688174
https://dx.doi.org/10.3389/fimmu.2018.02894
Access Level:acceso abierto
Palabra clave:Cancer
HLA-G
Immunosurveillance
MHC-I
Qa-2
Medicina
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spelling New Insights Into the Role of Qa-2 and HLA-G Non-classical MHC-I Complexes in MalignancyDa Silva, Istéfani L.Montero-Montero, LucíaFerreira, EnioQuintanilla, MiguelCancerHLA-GImmunosurveillanceMHC-IQa-2MedicinaIt is well established that the immune system can identify and destroy neoplastic transformed cells in a process known as immunosurveillance. Most studies have focused on the classical major histocompatibility complex (MHC) class Ia molecules, which are known to play an important role on the presentation of tumor antigens to the immune system in order to activate a response against tumor cells. However, a larger family of non-classical MHC class Ib-related molecules has received less attention. In this mini-review, we discuss the role of class Ib murine Qa-2 and its proposed human HLA-G homolog on immunosurveillance during embryogenesis and cancer. Whereas, both HLA-G and Qa-2 are involved in immune tolerance in pregnancy, the current evidence suggests that they play opposite roles in cancer. HLA-G appears to promote tumor progression while Qa-2 acts as a tumor suppressor awaking the immune system to reject tumor cells, as suggested by studies on different cancer cell models, such as melanoma, lymphoma, lung carcinoma, and our own results in mammary carcinoma.The research developed in our laboratories is supported by grants SAF2017-84183-R from the Spanish Ministry of Science, Innovation and Universities to MQ, and APQ-04269-10 and RED-00011-14 from the Foundation for Research Support of the State of Minas Gerais (FAPEMIG) to EFFrontiers Media20182018-12-06research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/688174https://dx.doi.org/10.3389/fimmu.2018.02894reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6881742026-06-23T12:46:27Z
dc.title.none.fl_str_mv New Insights Into the Role of Qa-2 and HLA-G Non-classical MHC-I Complexes in Malignancy
title New Insights Into the Role of Qa-2 and HLA-G Non-classical MHC-I Complexes in Malignancy
spellingShingle New Insights Into the Role of Qa-2 and HLA-G Non-classical MHC-I Complexes in Malignancy
Da Silva, Istéfani L.
Cancer
HLA-G
Immunosurveillance
MHC-I
Qa-2
Medicina
title_short New Insights Into the Role of Qa-2 and HLA-G Non-classical MHC-I Complexes in Malignancy
title_full New Insights Into the Role of Qa-2 and HLA-G Non-classical MHC-I Complexes in Malignancy
title_fullStr New Insights Into the Role of Qa-2 and HLA-G Non-classical MHC-I Complexes in Malignancy
title_full_unstemmed New Insights Into the Role of Qa-2 and HLA-G Non-classical MHC-I Complexes in Malignancy
title_sort New Insights Into the Role of Qa-2 and HLA-G Non-classical MHC-I Complexes in Malignancy
dc.creator.none.fl_str_mv Da Silva, Istéfani L.
Montero-Montero, Lucía
Ferreira, Enio
Quintanilla, Miguel
author Da Silva, Istéfani L.
author_facet Da Silva, Istéfani L.
Montero-Montero, Lucía
Ferreira, Enio
Quintanilla, Miguel
author_role author
author2 Montero-Montero, Lucía
Ferreira, Enio
Quintanilla, Miguel
author2_role author
author
author
dc.subject.none.fl_str_mv Cancer
HLA-G
Immunosurveillance
MHC-I
Qa-2
Medicina
topic Cancer
HLA-G
Immunosurveillance
MHC-I
Qa-2
Medicina
description It is well established that the immune system can identify and destroy neoplastic transformed cells in a process known as immunosurveillance. Most studies have focused on the classical major histocompatibility complex (MHC) class Ia molecules, which are known to play an important role on the presentation of tumor antigens to the immune system in order to activate a response against tumor cells. However, a larger family of non-classical MHC class Ib-related molecules has received less attention. In this mini-review, we discuss the role of class Ib murine Qa-2 and its proposed human HLA-G homolog on immunosurveillance during embryogenesis and cancer. Whereas, both HLA-G and Qa-2 are involved in immune tolerance in pregnancy, the current evidence suggests that they play opposite roles in cancer. HLA-G appears to promote tumor progression while Qa-2 acts as a tumor suppressor awaking the immune system to reject tumor cells, as suggested by studies on different cancer cell models, such as melanoma, lymphoma, lung carcinoma, and our own results in mammary carcinoma.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-12-06
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/688174
https://dx.doi.org/10.3389/fimmu.2018.02894
url http://hdl.handle.net/10486/688174
https://dx.doi.org/10.3389/fimmu.2018.02894
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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