Residential exposure to traffic pollution and mammographic density in premenopausal women
Background: Mammographic density (MD) is the most important breast cancer biomarker. Ambient pollution is a carcinogen, and its relationship with MD is unclear. This study aims to explore the association between exposure to traffic pollution and MD in premenopausal women. Methodology: This Spanish c...
| Autores: | , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Instituto de Salud Carlos III (ISCIII) |
| Repositorio: | Repisalud |
| Idioma: | inglés |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/26934 |
| Acceso en línea: | https://hdl.handle.net/20.500.12105/26934 |
| Access Level: | acceso abierto |
| Palabra clave: | Air pollution Breast cancer Breast density DDM-Madrid Premenopausal Traffic exposure Adult Air Pollutants Breast Density Breast Neoplasms Cross-Sectional Studies Environmental Exposure Female Humans Mammography Middle Aged Premenopause Spain Traffic-Related Pollution Vehicle Emissions |
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Residential exposure to traffic pollution and mammographic density in premenopausal womenJiménez, TamaraDomínguez-Castillo, AlejandroFernandez de Larrea-Baz, Nereade Lucas, Maria PilarSierra, Maria AngelesSalas-Trejo, DoloresLlobet, RafaelMartínez, InmaculadaPino, Marina NievesMartínez-Cortés, MercedesPerez-Gomez, BeatrizPollan-Santamaria, MarinaLope Carvajal, VirginiaGarcía-Pérez, JavierAir pollutionBreast cancerBreast densityDDM-MadridPremenopausalTraffic exposureAdultAir PollutantsBreast DensityBreast NeoplasmsCross-Sectional StudiesEnvironmental ExposureFemaleHumansMammographyMiddle AgedPremenopauseSpainTraffic-Related PollutionVehicle EmissionsBackground: Mammographic density (MD) is the most important breast cancer biomarker. Ambient pollution is a carcinogen, and its relationship with MD is unclear. This study aims to explore the association between exposure to traffic pollution and MD in premenopausal women. Methodology: This Spanish cross-sectional study involved 769 women attending gynecological examinations in Madrid. Annual Average Daily Traffic (AADT), extracted from 1944 measurement road points provided by the City Council of Madrid, was weighted by distances (d) between road points and women's addresses to develop a Weighted Traffic Exposure Index (WTEI). Three methods were employed: method-1 (1dAADT), method-2 (1dAADT), and method-3 (eAADT). Multiple linear regression models, considering both log-transformed percentage of MD and untransformed MD, were used to estimate MD differences by WTEI quartiles, through two strategies: "exposed (exposure buffers between 50 and 200 m) vs. not exposed (>200 m)"; and "degree of traffic exposure". Results: Results showed no association between MD and traffic pollution according to buffers of exposure to the WTEI (first strategy) for the three methods. The highest reductions in MD, although not statistically significant, were detected in the quartile with the highest traffic exposure. For instance, method-3 revealed a suggestive inverse trend (e = 1.23, e = 0.96, e = 0.85, e = 0.85, p-trend = 0.099) in the case of 75 m buffer. Similar non-statistically significant trends were observed with Methods-1 and -2. When we examined the effect of traffic exposure considering all the 1944 measurement road points in every participant (second strategy), results showed no association for any of the three methods. A slightly decreased MD, although not significant, was observed only in the quartile with the highest traffic exposure: e = 0.98 (method-1), and e = 0.95 (methods-2 and -3). Conclusions: Our results showed no association between exposure to traffic pollution and MD in premenopausal women. Further research is needed to validate these findings.ElsevierInstituto de Salud Carlos III20252025-10-2220242024-06-1020242024-06-10research articlehttp://purl.org/coar/resource_type/c_2df8fbb1SMURhttp://purl.org/coar/version/c_71e4c1898caa6e32info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.12105/26934reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengInstituto de Salud Carlos III http://dx.doi.org/10.13039/501100004587 Not available Not availableInstituto de Salud Carlos III http://dx.doi.org/10.13039/501100004587 Not available Not availableInstituto de Salud Carlos III http://dx.doi.org/10.13039/501100004587 Not available Not availableopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/269342026-06-12T12:43:37Z |
| dc.title.none.fl_str_mv |
Residential exposure to traffic pollution and mammographic density in premenopausal women |
| title |
Residential exposure to traffic pollution and mammographic density in premenopausal women |
| spellingShingle |
Residential exposure to traffic pollution and mammographic density in premenopausal women Jiménez, Tamara Air pollution Breast cancer Breast density DDM-Madrid Premenopausal Traffic exposure Adult Air Pollutants Breast Density Breast Neoplasms Cross-Sectional Studies Environmental Exposure Female Humans Mammography Middle Aged Premenopause Spain Traffic-Related Pollution Vehicle Emissions |
| title_short |
Residential exposure to traffic pollution and mammographic density in premenopausal women |
| title_full |
Residential exposure to traffic pollution and mammographic density in premenopausal women |
| title_fullStr |
Residential exposure to traffic pollution and mammographic density in premenopausal women |
| title_full_unstemmed |
Residential exposure to traffic pollution and mammographic density in premenopausal women |
| title_sort |
Residential exposure to traffic pollution and mammographic density in premenopausal women |
| dc.creator.none.fl_str_mv |
Jiménez, Tamara Domínguez-Castillo, Alejandro Fernandez de Larrea-Baz, Nerea de Lucas, Maria Pilar Sierra, Maria Angeles Salas-Trejo, Dolores Llobet, Rafael Martínez, Inmaculada Pino, Marina Nieves Martínez-Cortés, Mercedes Perez-Gomez, Beatriz Pollan-Santamaria, Marina Lope Carvajal, Virginia García-Pérez, Javier |
| author |
Jiménez, Tamara |
| author_facet |
Jiménez, Tamara Domínguez-Castillo, Alejandro Fernandez de Larrea-Baz, Nerea de Lucas, Maria Pilar Sierra, Maria Angeles Salas-Trejo, Dolores Llobet, Rafael Martínez, Inmaculada Pino, Marina Nieves Martínez-Cortés, Mercedes Perez-Gomez, Beatriz Pollan-Santamaria, Marina Lope Carvajal, Virginia García-Pérez, Javier |
| author_role |
author |
| author2 |
Domínguez-Castillo, Alejandro Fernandez de Larrea-Baz, Nerea de Lucas, Maria Pilar Sierra, Maria Angeles Salas-Trejo, Dolores Llobet, Rafael Martínez, Inmaculada Pino, Marina Nieves Martínez-Cortés, Mercedes Perez-Gomez, Beatriz Pollan-Santamaria, Marina Lope Carvajal, Virginia García-Pérez, Javier |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Salud Carlos III |
| dc.subject.none.fl_str_mv |
Air pollution Breast cancer Breast density DDM-Madrid Premenopausal Traffic exposure Adult Air Pollutants Breast Density Breast Neoplasms Cross-Sectional Studies Environmental Exposure Female Humans Mammography Middle Aged Premenopause Spain Traffic-Related Pollution Vehicle Emissions |
| topic |
Air pollution Breast cancer Breast density DDM-Madrid Premenopausal Traffic exposure Adult Air Pollutants Breast Density Breast Neoplasms Cross-Sectional Studies Environmental Exposure Female Humans Mammography Middle Aged Premenopause Spain Traffic-Related Pollution Vehicle Emissions |
| description |
Background: Mammographic density (MD) is the most important breast cancer biomarker. Ambient pollution is a carcinogen, and its relationship with MD is unclear. This study aims to explore the association between exposure to traffic pollution and MD in premenopausal women. Methodology: This Spanish cross-sectional study involved 769 women attending gynecological examinations in Madrid. Annual Average Daily Traffic (AADT), extracted from 1944 measurement road points provided by the City Council of Madrid, was weighted by distances (d) between road points and women's addresses to develop a Weighted Traffic Exposure Index (WTEI). Three methods were employed: method-1 (1dAADT), method-2 (1dAADT), and method-3 (eAADT). Multiple linear regression models, considering both log-transformed percentage of MD and untransformed MD, were used to estimate MD differences by WTEI quartiles, through two strategies: "exposed (exposure buffers between 50 and 200 m) vs. not exposed (>200 m)"; and "degree of traffic exposure". Results: Results showed no association between MD and traffic pollution according to buffers of exposure to the WTEI (first strategy) for the three methods. The highest reductions in MD, although not statistically significant, were detected in the quartile with the highest traffic exposure. For instance, method-3 revealed a suggestive inverse trend (e = 1.23, e = 0.96, e = 0.85, e = 0.85, p-trend = 0.099) in the case of 75 m buffer. Similar non-statistically significant trends were observed with Methods-1 and -2. When we examined the effect of traffic exposure considering all the 1944 measurement road points in every participant (second strategy), results showed no association for any of the three methods. A slightly decreased MD, although not significant, was observed only in the quartile with the highest traffic exposure: e = 0.98 (method-1), and e = 0.95 (methods-2 and -3). Conclusions: Our results showed no association between exposure to traffic pollution and MD in premenopausal women. Further research is needed to validate these findings. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 2024-06-10 2024 2024-06-10 2025 2025-10-22 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 SMUR http://purl.org/coar/version/c_71e4c1898caa6e32 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/20.500.12105/26934 |
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https://hdl.handle.net/20.500.12105/26934 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Instituto de Salud Carlos III http://dx.doi.org/10.13039/501100004587 Not available Not available Instituto de Salud Carlos III http://dx.doi.org/10.13039/501100004587 Not available Not available Instituto de Salud Carlos III http://dx.doi.org/10.13039/501100004587 Not available Not available |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII) |
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Instituto de Salud Carlos III (ISCIII) |
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