[Translated article] Should Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde (Lyral®) Still be Part of the Baseline Series?

BACKGROUND AND OBJECTIVES: Hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC), or Lyral®, is a fragrance marker that is part of the Fragrance Mix II (FM II) and is still patched as an independent allergen within the European and other baseline series despite the European Commission banning its use...

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Detalles Bibliográficos
Autores: Hernández Fernández CP, Borrego L, Giménez Arnau AM, Sanz Sánchez T, Carrascosa Carrillo JM, Zaragoza Ninet V, Serra Baldrich E, Miquel Miquel FJ, Silvestre Salvador JF, Córdoba Guijarro S, Sánchez Gilo A, Mercader García P, Navarro Triviño F, Tous Romero F, Rodríguez Serna M, Melé Ninot G, Ruiz González I, Gómez de la Fuente E, Pastor Nieto MA, Sánchez-Pedreño Guillén P, Sánchez Pérez J, Pereyra Rodríguez JJ, Gatica Ortega ME, González Pérez R, García Doval I, Gallego Descalzo MA
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p11494
Acceso en línea:https://isabial.portalinvestigacion.com/publicaciones11494
https://doi.org/10.1016/j.ad.2025.10.016
Access Level:acceso abierto
Palabra clave:Baseline series
Batería estándar
Contact dermatitis
Dermatitis de contacto
España
Hidroxiisohexil 3-ciclohexeno carboxaldehído
Hydroxyisohexyl 3-cyclohexene carboxaldehyde
Lyral®
Patch tests
Pruebas epicutáneas
Spain
Descripción
Sumario:BACKGROUND AND OBJECTIVES: Hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC), or Lyral®, is a fragrance marker that is part of the Fragrance Mix II (FM II) and is still patched as an independent allergen within the European and other baseline series despite the European Commission banning its use in cosmetics in 2021. We aimed to study the prevalence of sensitization to the HICC in Spain and its simultaneous positivity with the FM II to determine whether it should be part of the Spanish baseline series. MATERIAL AND METHOD: We analyzed all consecutive patients simultaneously patch-tested with HICC and FM II within the Spanish Contact Dermatitis Registry (REIDAC) from June 1st, 2018 to December 31st, 2023. RESULTS: A total of 96 (0.8%) out of 12,029 patients analyzed yielded positive to HICC and 396 (3.3%) to FM II. In 53% and 64% of the patients, respectively, findings were considered currently relevant. A total of 72 out of 96 (75%) HICC positives would be detected if only FM II was patched. CONCLUSIONS: Prevalence of HICC sensitization in Spain is low and has decreased in recent years. HICC is a prohibited fragrance in cosmetics and FM II detects 3 in 4 sensitized patients. Our results suggest that HICC should remain outside the Spanish baseline series and support its exclusion from the European baseline series.

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