Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

Despite some epidemiological evidence on the protective effects of polyphenol intake on epithelial ovarian cancer (EOC) risk from case-control studies, the evidence is scarce from prospective studies and non-existent for several polyphenol classes. Therefore, we aimed to investigate the associations...

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Autores: Londoño, Catalina, Cayssials, Valerie, Villasante, Izar de, Crous Bou, Marta, Scalbert, Augustin, Weiderpass, Elisabete, Agudo, Antonio, Tjønneland, Anne, Olsen, Anja, Overvad, Kim, Katzke, Verena, Schulze, Matthias B., Palli, Domenico, Krogh, Vittorio, Santucci de Magistris, Maria, Tumino, Rosario, Ricceri, Fulvio, Gram, Inger T., Rylander, Charlotta, Skeie, Guri, Sánchez Pérez, María José, Amiano, Pilar, Huerta, José María, Barricarte, Aurelio, Sartor, Hanna, Sonestedt, Emily, Esberg, Anders, Idahl, Annika, Mahamat-Saleh, Yahya, Laouali, Nasser, Kvaskoff, Marina, Turzanski Fortner, Renée, Zamora-Ros, Raul
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/180015
Acceso en línea:https://hdl.handle.net/2445/180015
Access Level:acceso abierto
Palabra clave:Càncer d'ovari
Polifenols
Factors de risc en les malalties
Ovarian cancer
Polyphenols
Diseases--Risk factors
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spelling Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) StudyLondoño, CatalinaCayssials, ValerieVillasante, Izar deCrous Bou, MartaScalbert, AugustinWeiderpass, ElisabeteAgudo, AntonioTjønneland, AnneOlsen, AnjaOvervad, KimKatzke, VerenaSchulze, Matthias B.Palli, DomenicoKrogh, VittorioSantucci de Magistris, MariaTumino, RosarioRicceri, FulvioGram, Inger T.Rylander, CharlottaSkeie, GuriSánchez Pérez, María JoséAmiano, PilarHuerta, José MaríaBarricarte, AurelioSartor, HannaSonestedt, EmilyEsberg, AndersIdahl, AnnikaMahamat-Saleh, YahyaLaouali, NasserKvaskoff, MarinaTurzanski Fortner, RenéeZamora-Ros, RaulCàncer d'ovariPolifenolsFactors de risc en les malaltiesOvarian cancerPolyphenolsDiseases--Risk factorsDespite some epidemiological evidence on the protective effects of polyphenol intake on epithelial ovarian cancer (EOC) risk from case-control studies, the evidence is scarce from prospective studies and non-existent for several polyphenol classes. Therefore, we aimed to investigate the associations between the intake of total, classes and subclasses of polyphenols and EOC risk in a large prospective study. The study was conducted in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which included 309,129 adult women recruited mostly from the general population. Polyphenol intake was assessed through validated country-specific dietary questionnaires and the Phenol-Explorer database. During a mean follow-up of 14 years, 1469 first incident EOC cases (including 806 serous, 129 endometrioid, 102 mucinous, and 67 clear cell tumours) were identified. In multivariable-adjusted Cox regression models, the hazard ratio in the highest quartile of total polyphenol intake compared with the lowest quartile (HRQ4vsQ1) was 1.14 (95% CI 0.94-1.39; p-trend = 0.11). Similarly, the intake of most classes and subclasses of polyphenols were not related to either overall EOC risk or any EOC subtype. A borderline statistically significant positive association was observed between phenolic acid intake (HRQ4vsQ1 = 1.20, 95% CI 1.01-1.43; p-trend = 0.02) and EOC risk, especially for the serous subtype and in women with obesity, although these associations did not exceed the Bonferroni correction threshold. The current results do not support any association between polyphenol intake and EOC in our large European prospective study. Results regarding phenolic acid intake need further investigation.MDPI AG2021202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfhttps://hdl.handle.net/2445/180015Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/antiox10081249Antioxidants, 2021, vol. 10, num. 8, p. 1249https://doi.org/10.3390/antiox10081249cc by (c) Londoño, Catalina et al, 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1800152026-05-29T05:05:01Z
dc.title.none.fl_str_mv Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
title Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
spellingShingle Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
Londoño, Catalina
Càncer d'ovari
Polifenols
Factors de risc en les malalties
Ovarian cancer
Polyphenols
Diseases--Risk factors
title_short Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
title_full Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
title_fullStr Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
title_full_unstemmed Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
title_sort Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
dc.creator.none.fl_str_mv Londoño, Catalina
Cayssials, Valerie
Villasante, Izar de
Crous Bou, Marta
Scalbert, Augustin
Weiderpass, Elisabete
Agudo, Antonio
Tjønneland, Anne
Olsen, Anja
Overvad, Kim
Katzke, Verena
Schulze, Matthias B.
Palli, Domenico
Krogh, Vittorio
Santucci de Magistris, Maria
Tumino, Rosario
Ricceri, Fulvio
Gram, Inger T.
Rylander, Charlotta
Skeie, Guri
Sánchez Pérez, María José
Amiano, Pilar
Huerta, José María
Barricarte, Aurelio
Sartor, Hanna
Sonestedt, Emily
Esberg, Anders
Idahl, Annika
Mahamat-Saleh, Yahya
Laouali, Nasser
Kvaskoff, Marina
Turzanski Fortner, Renée
Zamora-Ros, Raul
author Londoño, Catalina
author_facet Londoño, Catalina
Cayssials, Valerie
Villasante, Izar de
Crous Bou, Marta
Scalbert, Augustin
Weiderpass, Elisabete
Agudo, Antonio
Tjønneland, Anne
Olsen, Anja
Overvad, Kim
Katzke, Verena
Schulze, Matthias B.
Palli, Domenico
Krogh, Vittorio
Santucci de Magistris, Maria
Tumino, Rosario
Ricceri, Fulvio
Gram, Inger T.
Rylander, Charlotta
Skeie, Guri
Sánchez Pérez, María José
Amiano, Pilar
Huerta, José María
Barricarte, Aurelio
Sartor, Hanna
Sonestedt, Emily
Esberg, Anders
Idahl, Annika
Mahamat-Saleh, Yahya
Laouali, Nasser
Kvaskoff, Marina
Turzanski Fortner, Renée
Zamora-Ros, Raul
author_role author
author2 Cayssials, Valerie
Villasante, Izar de
Crous Bou, Marta
Scalbert, Augustin
Weiderpass, Elisabete
Agudo, Antonio
Tjønneland, Anne
Olsen, Anja
Overvad, Kim
Katzke, Verena
Schulze, Matthias B.
Palli, Domenico
Krogh, Vittorio
Santucci de Magistris, Maria
Tumino, Rosario
Ricceri, Fulvio
Gram, Inger T.
Rylander, Charlotta
Skeie, Guri
Sánchez Pérez, María José
Amiano, Pilar
Huerta, José María
Barricarte, Aurelio
Sartor, Hanna
Sonestedt, Emily
Esberg, Anders
Idahl, Annika
Mahamat-Saleh, Yahya
Laouali, Nasser
Kvaskoff, Marina
Turzanski Fortner, Renée
Zamora-Ros, Raul
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer d'ovari
Polifenols
Factors de risc en les malalties
Ovarian cancer
Polyphenols
Diseases--Risk factors
topic Càncer d'ovari
Polifenols
Factors de risc en les malalties
Ovarian cancer
Polyphenols
Diseases--Risk factors
description Despite some epidemiological evidence on the protective effects of polyphenol intake on epithelial ovarian cancer (EOC) risk from case-control studies, the evidence is scarce from prospective studies and non-existent for several polyphenol classes. Therefore, we aimed to investigate the associations between the intake of total, classes and subclasses of polyphenols and EOC risk in a large prospective study. The study was conducted in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which included 309,129 adult women recruited mostly from the general population. Polyphenol intake was assessed through validated country-specific dietary questionnaires and the Phenol-Explorer database. During a mean follow-up of 14 years, 1469 first incident EOC cases (including 806 serous, 129 endometrioid, 102 mucinous, and 67 clear cell tumours) were identified. In multivariable-adjusted Cox regression models, the hazard ratio in the highest quartile of total polyphenol intake compared with the lowest quartile (HRQ4vsQ1) was 1.14 (95% CI 0.94-1.39; p-trend = 0.11). Similarly, the intake of most classes and subclasses of polyphenols were not related to either overall EOC risk or any EOC subtype. A borderline statistically significant positive association was observed between phenolic acid intake (HRQ4vsQ1 = 1.20, 95% CI 1.01-1.43; p-trend = 0.02) and EOC risk, especially for the serous subtype and in women with obesity, although these associations did not exceed the Bonferroni correction threshold. The current results do not support any association between polyphenol intake and EOC in our large European prospective study. Results regarding phenolic acid intake need further investigation.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/180015
url https://hdl.handle.net/2445/180015
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/antiox10081249
Antioxidants, 2021, vol. 10, num. 8, p. 1249
https://doi.org/10.3390/antiox10081249
dc.rights.none.fl_str_mv cc by (c) Londoño, Catalina et al, 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Londoño, Catalina et al, 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI AG
publisher.none.fl_str_mv MDPI AG
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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