Development of a mucoadhesive delivery system for control release of doxepin with application in vaginal pain relief assciated with gynecological surgery.

The main purpose of this study was to develop a semisolid mucoadhesive formulation for the non-invasive vaginal administration of doxepin (DOX) for relief of pain derived from the scarring process after surgery. An orafix® platform loading DOX was tested for adequate stability, rheology and vaginal...

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Autores: Sanz Casañas, Roser, Clares Naveros, Beatriz, Mallandrich Miret, Mireia, Suñer Carbó, J. (Joaquim), Montes López, María Jesús, Calpena Campmany, Ana
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/216343
Acceso en línea:https://hdl.handle.net/2445/216343
Access Level:acceso abierto
Palabra clave:Malalties de la vagina
Candidiasi
Malalties de l'aparell genital femení
Vagina diseases
Candidiasis
Female reproductive system diseases
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spelling Development of a mucoadhesive delivery system for control release of doxepin with application in vaginal pain relief assciated with gynecological surgery.Sanz Casañas, RoserClares Naveros, BeatrizMallandrich Miret, MireiaSuñer Carbó, J. (Joaquim)Montes López, María JesúsCalpena Campmany, AnaMalalties de la vaginaCandidiasiMalalties de l'aparell genital femeníVagina diseasesCandidiasisFemale reproductive system diseasesThe main purpose of this study was to develop a semisolid mucoadhesive formulation for the non-invasive vaginal administration of doxepin (DOX) for relief of pain derived from the scarring process after surgery. An orafix® platform loading DOX was tested for adequate stability, rheology and vaginal mucoadhesion capacity. The formulation exhibited appropriate pH and was microbiologically stable. The rheological studies confirmed its pseudoplastic and thixotropic nature with prevalence of the elastic behavior component over the viscous one. Appropriate syringeability and spreadability results were also confirmed. Different experiments showed adequate mucoadhesion capacity even in the presence of simulated vaginal fluid. Finally, DOX release, permeation and retention in vaginal mucosa studies were also accomplished with promising results. DOX release kinetics followed the modified Higuchi model and the permeation studies did not render such high values as to suggest potential systemic absorption which could lead to undesirable systemic side effects. Therefore, we can hypostatize that the proposed formulation may assist to fill in the therapeutic gap regarding pure pain relief at local level in vagina.Elsevier B.V.2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/216343Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1016/j.ijpharm.2017.11.027International Journal of Pharmaceutics, 2017, vol. 535, p. 393-401https://doi.org/10.1016/j.ijpharm.2017.11.027cc-by-nc-nd (c) Elsevier B.V., 2017http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2163432026-05-27T06:46:51Z
dc.title.none.fl_str_mv Development of a mucoadhesive delivery system for control release of doxepin with application in vaginal pain relief assciated with gynecological surgery.
title Development of a mucoadhesive delivery system for control release of doxepin with application in vaginal pain relief assciated with gynecological surgery.
spellingShingle Development of a mucoadhesive delivery system for control release of doxepin with application in vaginal pain relief assciated with gynecological surgery.
Sanz Casañas, Roser
Malalties de la vagina
Candidiasi
Malalties de l'aparell genital femení
Vagina diseases
Candidiasis
Female reproductive system diseases
title_short Development of a mucoadhesive delivery system for control release of doxepin with application in vaginal pain relief assciated with gynecological surgery.
title_full Development of a mucoadhesive delivery system for control release of doxepin with application in vaginal pain relief assciated with gynecological surgery.
title_fullStr Development of a mucoadhesive delivery system for control release of doxepin with application in vaginal pain relief assciated with gynecological surgery.
title_full_unstemmed Development of a mucoadhesive delivery system for control release of doxepin with application in vaginal pain relief assciated with gynecological surgery.
title_sort Development of a mucoadhesive delivery system for control release of doxepin with application in vaginal pain relief assciated with gynecological surgery.
dc.creator.none.fl_str_mv Sanz Casañas, Roser
Clares Naveros, Beatriz
Mallandrich Miret, Mireia
Suñer Carbó, J. (Joaquim)
Montes López, María Jesús
Calpena Campmany, Ana
author Sanz Casañas, Roser
author_facet Sanz Casañas, Roser
Clares Naveros, Beatriz
Mallandrich Miret, Mireia
Suñer Carbó, J. (Joaquim)
Montes López, María Jesús
Calpena Campmany, Ana
author_role author
author2 Clares Naveros, Beatriz
Mallandrich Miret, Mireia
Suñer Carbó, J. (Joaquim)
Montes López, María Jesús
Calpena Campmany, Ana
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Malalties de la vagina
Candidiasi
Malalties de l'aparell genital femení
Vagina diseases
Candidiasis
Female reproductive system diseases
topic Malalties de la vagina
Candidiasi
Malalties de l'aparell genital femení
Vagina diseases
Candidiasis
Female reproductive system diseases
description The main purpose of this study was to develop a semisolid mucoadhesive formulation for the non-invasive vaginal administration of doxepin (DOX) for relief of pain derived from the scarring process after surgery. An orafix® platform loading DOX was tested for adequate stability, rheology and vaginal mucoadhesion capacity. The formulation exhibited appropriate pH and was microbiologically stable. The rheological studies confirmed its pseudoplastic and thixotropic nature with prevalence of the elastic behavior component over the viscous one. Appropriate syringeability and spreadability results were also confirmed. Different experiments showed adequate mucoadhesion capacity even in the presence of simulated vaginal fluid. Finally, DOX release, permeation and retention in vaginal mucosa studies were also accomplished with promising results. DOX release kinetics followed the modified Higuchi model and the permeation studies did not render such high values as to suggest potential systemic absorption which could lead to undesirable systemic side effects. Therefore, we can hypostatize that the proposed formulation may assist to fill in the therapeutic gap regarding pure pain relief at local level in vagina.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/216343
url https://hdl.handle.net/2445/216343
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.ijpharm.2017.11.027
International Journal of Pharmaceutics, 2017, vol. 535, p. 393-401
https://doi.org/10.1016/j.ijpharm.2017.11.027
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Elsevier B.V., 2017
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Elsevier B.V., 2017
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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