MDMA attenuates THC withdrawal syndrome in mice

3, 4-Methylenedioxymethamphetamine (MDMA) and cannabis are widely abused illicit drugs that are frequently consumed in combination. Interactions between these two drugs have been reported in several pharmacological responses observed in animals, such as body temperature, anxiety, cognition and rewar...

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Autores: Touriño Raposo, Clara, Maldonado, Rafael, 1961-, Valverde Granados, Olga
Tipo de documento: artigo
Estado:Versión enviada para evaluación y publicación
Data de publicação:2007
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/16366
Acesso em linha:http://hdl.handle.net/10230/16366
http://dx.doi.org/10.1007/s00213-007-0772-5
Access Level:Acceso aberto
Palavra-chave:MDMA (Droga)
Drogues
Psychostimulant
Cannabinoid
Physical dependence
In vivo microdialysis
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spelling MDMA attenuates THC withdrawal syndrome in miceTouriño Raposo, ClaraMaldonado, Rafael, 1961-Valverde Granados, OlgaMDMA (Droga)DroguesPsychostimulantCannabinoidPhysical dependenceIn vivo microdialysis3, 4-Methylenedioxymethamphetamine (MDMA) and cannabis are widely abused illicit drugs that are frequently consumed in combination. Interactions between these two drugs have been reported in several pharmacological responses observed in animals, such as body temperature, anxiety, cognition and reward. However, the interaction between MDMA and cannabis in addictive processes such as physical dependence has not been elucidated yet. In this study, the effects of acute and chronic MDMA were evaluated on the behavioral manifestations of Δ9-tetrahydrocannabinol (THC) abstinence in mice. THC withdrawal syndrome was precipitated by injecting the cannabinoid antagonist rimonabant (10 mg/kg, i.p.) in mice chronically treated with THC, and receiving MDMA (2.5, 5 and 10 mg/kg i.p.) or saline just before the withdrawal induction or chronically after the THC administration. Both, chronic and acute MDMA decreased in a dose-dependent manner the severity of THC withdrawal. In vivo microdialysis experiments showed that acute MDMA (5 mg/kg, i.p.) administration increased extracellular serotonin levels in the prefrontal cortex, but not dopamine levels in the nucleus accumbens. Our results also indicate that the attenuation of THC abstinence symptoms was not due to a direct interaction between rimonabant and MDMA nor to the result of the locomotor stimulating effects of MDMA. The modulation of the cannabinoid withdrawal syndrome by acute or chronic MDMA suggests a possible mechanism to explain the associated consumption of these two drugs in humans.This study was supported by grants from Spanish MCYT (SAF 2004/568; BFU 2004/920BFI), Generalitat de Catalunya (2005SGR00131), European Communities (GENADDICT LSHM–CT–2004–005166) and NIH (Extra-mural research project #DA016768). CT has a fellowship supported by the Department of Education and Universities from Generalitat de Catalunya and by the Social European Fund. Ms Dulce Real in this work is kindly acknowledged for her excellent technical assistance in the in vivo microdialysis experiments.Springer201220122007info:eu-repo/semantics/articleinfo:eu-repo/semantics/submittedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/16366http://dx.doi.org/10.1007/s00213-007-0772-5reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésPsychopharmacology. 2007;193(1):75-84info:eu-repo/grantAgreement/EC/FP7/005166© 2007 Springer. The original publication is available at www.springerlink.cominfo:eu-repo/semantics/openAccessoai:recercat.cat:10230/163662026-05-29T05:05:01Z
dc.title.none.fl_str_mv MDMA attenuates THC withdrawal syndrome in mice
title MDMA attenuates THC withdrawal syndrome in mice
spellingShingle MDMA attenuates THC withdrawal syndrome in mice
Touriño Raposo, Clara
MDMA (Droga)
Drogues
Psychostimulant
Cannabinoid
Physical dependence
In vivo microdialysis
title_short MDMA attenuates THC withdrawal syndrome in mice
title_full MDMA attenuates THC withdrawal syndrome in mice
title_fullStr MDMA attenuates THC withdrawal syndrome in mice
title_full_unstemmed MDMA attenuates THC withdrawal syndrome in mice
title_sort MDMA attenuates THC withdrawal syndrome in mice
dc.creator.none.fl_str_mv Touriño Raposo, Clara
Maldonado, Rafael, 1961-
Valverde Granados, Olga
author Touriño Raposo, Clara
author_facet Touriño Raposo, Clara
Maldonado, Rafael, 1961-
Valverde Granados, Olga
author_role author
author2 Maldonado, Rafael, 1961-
Valverde Granados, Olga
author2_role author
author
dc.subject.none.fl_str_mv MDMA (Droga)
Drogues
Psychostimulant
Cannabinoid
Physical dependence
In vivo microdialysis
topic MDMA (Droga)
Drogues
Psychostimulant
Cannabinoid
Physical dependence
In vivo microdialysis
description 3, 4-Methylenedioxymethamphetamine (MDMA) and cannabis are widely abused illicit drugs that are frequently consumed in combination. Interactions between these two drugs have been reported in several pharmacological responses observed in animals, such as body temperature, anxiety, cognition and reward. However, the interaction between MDMA and cannabis in addictive processes such as physical dependence has not been elucidated yet. In this study, the effects of acute and chronic MDMA were evaluated on the behavioral manifestations of Δ9-tetrahydrocannabinol (THC) abstinence in mice. THC withdrawal syndrome was precipitated by injecting the cannabinoid antagonist rimonabant (10 mg/kg, i.p.) in mice chronically treated with THC, and receiving MDMA (2.5, 5 and 10 mg/kg i.p.) or saline just before the withdrawal induction or chronically after the THC administration. Both, chronic and acute MDMA decreased in a dose-dependent manner the severity of THC withdrawal. In vivo microdialysis experiments showed that acute MDMA (5 mg/kg, i.p.) administration increased extracellular serotonin levels in the prefrontal cortex, but not dopamine levels in the nucleus accumbens. Our results also indicate that the attenuation of THC abstinence symptoms was not due to a direct interaction between rimonabant and MDMA nor to the result of the locomotor stimulating effects of MDMA. The modulation of the cannabinoid withdrawal syndrome by acute or chronic MDMA suggests a possible mechanism to explain the associated consumption of these two drugs in humans.
publishDate 2007
dc.date.none.fl_str_mv 2007
2012
2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/submittedVersion
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/16366
http://dx.doi.org/10.1007/s00213-007-0772-5
url http://hdl.handle.net/10230/16366
http://dx.doi.org/10.1007/s00213-007-0772-5
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Psychopharmacology. 2007;193(1):75-84
info:eu-repo/grantAgreement/EC/FP7/005166
dc.rights.none.fl_str_mv © 2007 Springer. The original publication is available at www.springerlink.com
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © 2007 Springer. The original publication is available at www.springerlink.com
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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