Intermitochondrial cement (IMC) harbors piRNA biogenesis machinery and exonuclease domain-containing proteins EXD1 and EXD2 in mouse spermatocytes

[Background] Germ granules are large cytoplasmic ribonucleoprotein complexes that emerge in the germline to participate in RNA regulation. The two most prominent germ granules are the intermitochondrial cement (IMC) in meiotic spermatocytes and the chromatoid body (CB) in haploid round spermatids, b...

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Detalles Bibliográficos
Autores: Olotu, Opeyemi, Dowling, Mark, Homolka, David, Wojtas, Magdalena Natalia, Tran, Panyi, Lehtiniemi, Tiina, Da Ros, Matteo, Pillai, Ramesh S., Kotaja, Noora
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/339144
Acceso en línea:http://hdl.handle.net/10261/339144
https://api.elsevier.com/content/abstract/scopus_id/85146158967
Access Level:acceso abierto
Palabra clave:EXD1
EXD2
Chromatoid body
Intermitochondrial cement
piRNA
Spermatogenesis
Descripción
Sumario:[Background] Germ granules are large cytoplasmic ribonucleoprotein complexes that emerge in the germline to participate in RNA regulation. The two most prominent germ granules are the intermitochondrial cement (IMC) in meiotic spermatocytes and the chromatoid body (CB) in haploid round spermatids, both functionally linked to the PIWI-interacting RNA (piRNA) pathway.

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