Clinical Advances in Immunonutrition and Atherosclerosis: A Review.

Atherosclerosis is a chronic low-grade inflammatory disease that affects large and medium-sized arteries and is considered to be a major underlying cause of cardiovascular disease (CVD). The high risk of mortality by atherosclerosis has led to the development of new strategies for disease prevention...

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Autores: Ruíz León, Ana María, Lapuente, María, Estruch Riba, Ramon, Casas Rodríguez, Rosa M.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/183865
Acesso em linha:https://hdl.handle.net/2445/183865
Access Level:acceso abierto
Palavra-chave:Inflamació
Aterosclerosi
Malalties cardiovasculars
Inflammation
Atherosclerosis
Cardiovascular diseases
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spelling Clinical Advances in Immunonutrition and Atherosclerosis: A Review.Ruíz León, Ana MaríaLapuente, MaríaEstruch Riba, RamonCasas Rodríguez, Rosa M.InflamacióAterosclerosiMalalties cardiovascularsInflammationAtherosclerosisCardiovascular diseasesAtherosclerosis is a chronic low-grade inflammatory disease that affects large and medium-sized arteries and is considered to be a major underlying cause of cardiovascular disease (CVD). The high risk of mortality by atherosclerosis has led to the development of new strategies for disease prevention and management, including immunonutrition. Plant-based dietary patterns, functional foods, dietary supplements, and bioactive compounds such as the Mediterranean Diet, berries, polyunsaturated fatty acids, ω-3 and ω-6, vitamins E, A, C, and D, coenzyme Q10, as well as phytochemicals including isoflavones, stilbenes, and sterols have been associated with improvement in atheroma plaque at an inflammatory level. However, many of these correlations have been obtained in vitro and in experimental animals' models. On one hand, the present review focuses on the evidence obtained from epidemiological, dietary intervention and supplementation studies in humans supporting the role of immunonutrient supplementation and its effect on anti-inflammatory response in atherosclerotic disease. On the other hand, this review also analyzes the possible molecular mechanisms underlying the protective action of these supplements, which may lead a novel therapeutic approach to prevent or attenuate diet-related disease, such as atherosclerosis.Frontiers Media2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/183865Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3389/fimmu.2019.00837Frontiers in Immunology, 2019, num. 10https://doi.org/10.3389/fimmu.2019.00837cc-by (c) Ruíz León, Ana María et al., 2019https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1838652026-05-27T06:46:51Z
dc.title.none.fl_str_mv Clinical Advances in Immunonutrition and Atherosclerosis: A Review.
title Clinical Advances in Immunonutrition and Atherosclerosis: A Review.
spellingShingle Clinical Advances in Immunonutrition and Atherosclerosis: A Review.
Ruíz León, Ana María
Inflamació
Aterosclerosi
Malalties cardiovasculars
Inflammation
Atherosclerosis
Cardiovascular diseases
title_short Clinical Advances in Immunonutrition and Atherosclerosis: A Review.
title_full Clinical Advances in Immunonutrition and Atherosclerosis: A Review.
title_fullStr Clinical Advances in Immunonutrition and Atherosclerosis: A Review.
title_full_unstemmed Clinical Advances in Immunonutrition and Atherosclerosis: A Review.
title_sort Clinical Advances in Immunonutrition and Atherosclerosis: A Review.
dc.creator.none.fl_str_mv Ruíz León, Ana María
Lapuente, María
Estruch Riba, Ramon
Casas Rodríguez, Rosa M.
author Ruíz León, Ana María
author_facet Ruíz León, Ana María
Lapuente, María
Estruch Riba, Ramon
Casas Rodríguez, Rosa M.
author_role author
author2 Lapuente, María
Estruch Riba, Ramon
Casas Rodríguez, Rosa M.
author2_role author
author
author
dc.subject.none.fl_str_mv Inflamació
Aterosclerosi
Malalties cardiovasculars
Inflammation
Atherosclerosis
Cardiovascular diseases
topic Inflamació
Aterosclerosi
Malalties cardiovasculars
Inflammation
Atherosclerosis
Cardiovascular diseases
description Atherosclerosis is a chronic low-grade inflammatory disease that affects large and medium-sized arteries and is considered to be a major underlying cause of cardiovascular disease (CVD). The high risk of mortality by atherosclerosis has led to the development of new strategies for disease prevention and management, including immunonutrition. Plant-based dietary patterns, functional foods, dietary supplements, and bioactive compounds such as the Mediterranean Diet, berries, polyunsaturated fatty acids, ω-3 and ω-6, vitamins E, A, C, and D, coenzyme Q10, as well as phytochemicals including isoflavones, stilbenes, and sterols have been associated with improvement in atheroma plaque at an inflammatory level. However, many of these correlations have been obtained in vitro and in experimental animals' models. On one hand, the present review focuses on the evidence obtained from epidemiological, dietary intervention and supplementation studies in humans supporting the role of immunonutrient supplementation and its effect on anti-inflammatory response in atherosclerotic disease. On the other hand, this review also analyzes the possible molecular mechanisms underlying the protective action of these supplements, which may lead a novel therapeutic approach to prevent or attenuate diet-related disease, such as atherosclerosis.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/183865
url https://hdl.handle.net/2445/183865
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2019.00837
Frontiers in Immunology, 2019, num. 10
https://doi.org/10.3389/fimmu.2019.00837
dc.rights.none.fl_str_mv cc-by (c) Ruíz León, Ana María et al., 2019
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Ruíz León, Ana María et al., 2019
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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