Association of Iron Status and Intake During Pregnancy with Neuropsychological Outcomes in Children Aged 7 Years: The Prospective Birth Cohort Infancia y Medio Ambiente (INMA) Study.

Early iron status plays an important role in prenatal neurodevelopment. Iron deficiency and high iron status have been related to alterations in child cognitive development; however, there are no data about iron intake during pregnancy with other environmental factors in relation to long term cognit...

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Autores: Arija, Victoria, Hernandez-Martinez, Carmen, Tous, Monica, Canals, Josefa, Guxens, Monica, Fernandez-Barres, Silvia, Ibarluzea, Jesus, Babarro, Izaro, Soler-Blasco, Raquel, Llop, Sabrina, Vioque, Jesus, Sunyer, Jordi, Julvez, Jordi
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Recursos:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p5148
Acesso em linha:https://isabial.portalinvestigacion.com/publicaciones5148
Access Level:acceso abierto
Palavra-chave:attention, executive function, iron intake, iron status, neuropsychological function, pregnancy, working memory
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spelling Association of Iron Status and Intake During Pregnancy with Neuropsychological Outcomes in Children Aged 7 Years: The Prospective Birth Cohort Infancia y Medio Ambiente (INMA) Study.Arija, VictoriaHernandez-Martinez, CarmenTous, MonicaCanals, JosefaGuxens, MonicaFernandez-Barres, SilviaIbarluzea, JesusBabarro, IzaroSoler-Blasco, RaquelLlop, SabrinaVioque, JesusSunyer, JordiJulvez, Jordiattention, executive function, iron intake, iron status, neuropsychological function, pregnancy, working memoryEarly iron status plays an important role in prenatal neurodevelopment. Iron deficiency and high iron status have been related to alterations in child cognitive development; however, there are no data about iron intake during pregnancy with other environmental factors in relation to long term cognitive functioning of children. The aim of this study is to assess the relationship between maternal iron status and iron intake during pregnancy and child neuropsychological outcomes at 7 years of age. We used data from the INMA Cohort population-based study. Iron status during pregnancy was assessed according to serum ferritin levels, and iron intake was assessed with food frequency questionnaires. Working memory, attention, and executive function were assessed in children at 7 years old with the N-Back task, Attention Network Task, and the Trail Making Test, respectively. The results show that, after controlling for potential confounders, normal maternal serum ferritin levels (from 12 mg/L to 60 mg/L) and iron intake (from 14.5 mg/day to 30.0 mg/day), respectively, were related to better scores in working memory and executive functioning in offspring. Since these functions have been associated with better academic performance and adaptation to the environment, maintaining a good state of maternal iron from the beginning of pregnancy could be a valuable strategy for the community.MDPI2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones5148NutrientsISSN: 20726643reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p51482026-06-12T10:20:37Z
dc.title.none.fl_str_mv Association of Iron Status and Intake During Pregnancy with Neuropsychological Outcomes in Children Aged 7 Years: The Prospective Birth Cohort Infancia y Medio Ambiente (INMA) Study.
title Association of Iron Status and Intake During Pregnancy with Neuropsychological Outcomes in Children Aged 7 Years: The Prospective Birth Cohort Infancia y Medio Ambiente (INMA) Study.
spellingShingle Association of Iron Status and Intake During Pregnancy with Neuropsychological Outcomes in Children Aged 7 Years: The Prospective Birth Cohort Infancia y Medio Ambiente (INMA) Study.
Arija, Victoria
attention, executive function, iron intake, iron status, neuropsychological function, pregnancy, working memory
title_short Association of Iron Status and Intake During Pregnancy with Neuropsychological Outcomes in Children Aged 7 Years: The Prospective Birth Cohort Infancia y Medio Ambiente (INMA) Study.
title_full Association of Iron Status and Intake During Pregnancy with Neuropsychological Outcomes in Children Aged 7 Years: The Prospective Birth Cohort Infancia y Medio Ambiente (INMA) Study.
title_fullStr Association of Iron Status and Intake During Pregnancy with Neuropsychological Outcomes in Children Aged 7 Years: The Prospective Birth Cohort Infancia y Medio Ambiente (INMA) Study.
title_full_unstemmed Association of Iron Status and Intake During Pregnancy with Neuropsychological Outcomes in Children Aged 7 Years: The Prospective Birth Cohort Infancia y Medio Ambiente (INMA) Study.
title_sort Association of Iron Status and Intake During Pregnancy with Neuropsychological Outcomes in Children Aged 7 Years: The Prospective Birth Cohort Infancia y Medio Ambiente (INMA) Study.
dc.creator.none.fl_str_mv Arija, Victoria
Hernandez-Martinez, Carmen
Tous, Monica
Canals, Josefa
Guxens, Monica
Fernandez-Barres, Silvia
Ibarluzea, Jesus
Babarro, Izaro
Soler-Blasco, Raquel
Llop, Sabrina
Vioque, Jesus
Sunyer, Jordi
Julvez, Jordi
author Arija, Victoria
author_facet Arija, Victoria
Hernandez-Martinez, Carmen
Tous, Monica
Canals, Josefa
Guxens, Monica
Fernandez-Barres, Silvia
Ibarluzea, Jesus
Babarro, Izaro
Soler-Blasco, Raquel
Llop, Sabrina
Vioque, Jesus
Sunyer, Jordi
Julvez, Jordi
author_role author
author2 Hernandez-Martinez, Carmen
Tous, Monica
Canals, Josefa
Guxens, Monica
Fernandez-Barres, Silvia
Ibarluzea, Jesus
Babarro, Izaro
Soler-Blasco, Raquel
Llop, Sabrina
Vioque, Jesus
Sunyer, Jordi
Julvez, Jordi
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv attention, executive function, iron intake, iron status, neuropsychological function, pregnancy, working memory
topic attention, executive function, iron intake, iron status, neuropsychological function, pregnancy, working memory
description Early iron status plays an important role in prenatal neurodevelopment. Iron deficiency and high iron status have been related to alterations in child cognitive development; however, there are no data about iron intake during pregnancy with other environmental factors in relation to long term cognitive functioning of children. The aim of this study is to assess the relationship between maternal iron status and iron intake during pregnancy and child neuropsychological outcomes at 7 years of age. We used data from the INMA Cohort population-based study. Iron status during pregnancy was assessed according to serum ferritin levels, and iron intake was assessed with food frequency questionnaires. Working memory, attention, and executive function were assessed in children at 7 years old with the N-Back task, Attention Network Task, and the Trail Making Test, respectively. The results show that, after controlling for potential confounders, normal maternal serum ferritin levels (from 12 mg/L to 60 mg/L) and iron intake (from 14.5 mg/day to 30.0 mg/day), respectively, were related to better scores in working memory and executive functioning in offspring. Since these functions have been associated with better academic performance and adaptation to the environment, maintaining a good state of maternal iron from the beginning of pregnancy could be a valuable strategy for the community.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://isabial.portalinvestigacion.com/publicaciones5148
url https://isabial.portalinvestigacion.com/publicaciones5148
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Nutrients
ISSN: 20726643
reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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