Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice

Endometriosis is a disease defined by the presence of endometrial tissue in extrauterine locations. This chronic condition is frequently associated with pain and emotional disorders and has been related with altered immune function. However, the specific involvement of immune cells in pain and behav...

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Detalhes bibliográficos
Autores: Escudero Lara, Alejandra, 1992-, Cabañero Ferri, David, Maldonado, Rafael, 1961-
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2022
País:España
Recursos:Universitat Pompeu Fabra
Repositório:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/55162
Acesso em linha:http://hdl.handle.net/10230/55162
http://dx.doi.org/10.3389/fnbeh.2022.946975
Access Level:Acceso aberto
Palavra-chave:CD4
Anxiety
Chronic pelvic pain
Endometriosis
Female
Neuroinflammatory
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spelling Contribution of CD4+ cells in the emotional alterations induced by endometriosis in miceEscudero Lara, Alejandra, 1992-Cabañero Ferri, DavidMaldonado, Rafael, 1961-CD4AnxietyChronic pelvic painEndometriosisFemaleNeuroinflammatoryEndometriosis is a disease defined by the presence of endometrial tissue in extrauterine locations. This chronic condition is frequently associated with pain and emotional disorders and has been related with altered immune function. However, the specific involvement of immune cells in pain and behavioral symptoms of endometriosis has not been yet elucidated. Here, we implement a mouse model of non-surgical endometriosis in which immunocompetent mice develop abdomino-pelvic hypersensitivity, cognitive deficits, anxiety and depressive-like behaviors. This behavioral phenotype correlates with expression of inflammatory markers in the brain, including the immune cell marker CD4. Depletion of CD4 + cells decreases the anxiety-like behavior of mice subjected to the endometriosis model, whereas abdomino-pelvic hypersensitivity, depressive-like behavior and cognitive deficits remain unaltered. The present data reveal the involvement of the immune response characterized by CD4 + white blood cells in the anxiety-like behavior induced by endometriosis in mice. This model, which recapitulates the symptoms of human endometriosis, may be a useful tool to study the immune mechanisms involved in pain and behavioral alterations associated to endometriosis.“Instituto de Salud Carlos III,” “Redes temáticas de investigación cooperativa en salud—Red de trastornos adictivos” (#RD16/0017/0020), “Ministerio de Ciencia e Innovación” MICIN y “Agencia Estatal de Investigación” AEI (#PID2020-120029GBI00/MICIN/AEI/10.13039/50110001 1033), and “Generalitat de Catalunya- Agència de Gestió d’Ajuts Universitaris i de Recerca-AGAUR” (#2017-SGR-669 and #ICREA Acadèmia2020) to RM are acknowledged.Frontiers202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/55162http://dx.doi.org/10.3389/fnbeh.2022.946975reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésFront Behav Neurosci. 2022 Oct 12;16:946975info:eu-repo/grantAgreement/ES/2PE/PID2020-120029GB-I00© 2022 Escudero-Lara, Cabañero and Maldonado. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/551622026-06-12T07:21:37Z
dc.title.none.fl_str_mv Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice
title Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice
spellingShingle Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice
Escudero Lara, Alejandra, 1992-
CD4
Anxiety
Chronic pelvic pain
Endometriosis
Female
Neuroinflammatory
title_short Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice
title_full Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice
title_fullStr Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice
title_full_unstemmed Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice
title_sort Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice
dc.creator.none.fl_str_mv Escudero Lara, Alejandra, 1992-
Cabañero Ferri, David
Maldonado, Rafael, 1961-
author Escudero Lara, Alejandra, 1992-
author_facet Escudero Lara, Alejandra, 1992-
Cabañero Ferri, David
Maldonado, Rafael, 1961-
author_role author
author2 Cabañero Ferri, David
Maldonado, Rafael, 1961-
author2_role author
author
dc.subject.none.fl_str_mv CD4
Anxiety
Chronic pelvic pain
Endometriosis
Female
Neuroinflammatory
topic CD4
Anxiety
Chronic pelvic pain
Endometriosis
Female
Neuroinflammatory
description Endometriosis is a disease defined by the presence of endometrial tissue in extrauterine locations. This chronic condition is frequently associated with pain and emotional disorders and has been related with altered immune function. However, the specific involvement of immune cells in pain and behavioral symptoms of endometriosis has not been yet elucidated. Here, we implement a mouse model of non-surgical endometriosis in which immunocompetent mice develop abdomino-pelvic hypersensitivity, cognitive deficits, anxiety and depressive-like behaviors. This behavioral phenotype correlates with expression of inflammatory markers in the brain, including the immune cell marker CD4. Depletion of CD4 + cells decreases the anxiety-like behavior of mice subjected to the endometriosis model, whereas abdomino-pelvic hypersensitivity, depressive-like behavior and cognitive deficits remain unaltered. The present data reveal the involvement of the immune response characterized by CD4 + white blood cells in the anxiety-like behavior induced by endometriosis in mice. This model, which recapitulates the symptoms of human endometriosis, may be a useful tool to study the immune mechanisms involved in pain and behavioral alterations associated to endometriosis.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/55162
http://dx.doi.org/10.3389/fnbeh.2022.946975
url http://hdl.handle.net/10230/55162
http://dx.doi.org/10.3389/fnbeh.2022.946975
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Front Behav Neurosci. 2022 Oct 12;16:946975
info:eu-repo/grantAgreement/ES/2PE/PID2020-120029GB-I00
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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