The role of predominant polarity in older age bipolar disorder

Introduction: Predominant polarity (PP) has emerged as a valuable course specifier in bipolar disorder (BD) with implications for prognosis and treatment planning. As the BD population ages, understanding its clinical characteristics becomes essential to tailor personalized interventions across the...

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Autores: Sommerhof, Constanza, Bort, Marta, D’Alessandro, Giulia, Fico, Giovanna, De Prisco, Michele, Oliva, Vincenzo, Solé Cabezuelo, Brisa, Torrent Font, Carla, Murru, Andrea, Ruiz, Andrea, Rodríguez-Rey, Arturo, Sánchez-Moreno, José, Jiménez Martínez, Esther, Martínez-Arán, Anabel, 1971-, Vieta i Pascual, Eduard, 1963-, Montejo Egido, Laura
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/223981
Acceso en línea:https://hdl.handle.net/2445/223981
Access Level:acceso abierto
Palabra clave:Trastorn bipolar
Persones grans
Manic-depressive illness
Older people
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spelling The role of predominant polarity in older age bipolar disorderSommerhof, ConstanzaBort, MartaD’Alessandro, GiuliaFico, GiovannaDe Prisco, MicheleOliva, VincenzoSolé Cabezuelo, BrisaTorrent Font, CarlaMurru, AndreaRuiz, AndreaRodríguez-Rey, ArturoSánchez-Moreno, JoséJiménez Martínez, EstherMartínez-Arán, Anabel, 1971-Vieta i Pascual, Eduard, 1963-Montejo Egido, LauraTrastorn bipolarPersones gransManic-depressive illnessOlder peopleIntroduction: Predominant polarity (PP) has emerged as a valuable course specifier in bipolar disorder (BD) with implications for prognosis and treatment planning. As the BD population ages, understanding its clinical characteristics becomes essential to tailor personalized interventions across the lifespan. This study aimed to characterize the distribution and clinical profiles of PP subgroups in a cohort of older adults with BD (OABD). Methods: This cross-sectional study included 101 euthymic OABD aged >50 years. Clinical, neuropsychological and functional characteristics were compared between depressive (DPP), manic (MPP), and undetermined predominant polarity (UPP) subgroups, based on at least 2/3 of lifetime episodes being either depressive or manic polarity. Results: UPP was the most frequent PP in OABD (59.4%), followed by DPP (27.7%) and MPP (12.9%). Patients with DPP presented a later age of onset, a depressive first episode, less psychiatric hospitalizations, and a trend to outperform MPP and UPP in visual memory. Participants with MPP presented more frequently with manic onset. The UPP subgroup exhibited worse clinical outcomes, including higher number of total episodes, more frequent suicidal ideation and seasonality, and worse financial disability compared to DPP. Conclusion: PP classification distinguishes meaningful clinical and cognitive subgroups in OABD. The UPP subgroup associates with greater illness severity and functional impairment. These findings support the integration of PP into personalized treatment and prevention strategies in aging BD. Future longitudinal studies are needed to further clarify the trajectory of PP across the lifespan.Springer Open2025202520252025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/223981Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1186/s40345-025-00392-9International Journal of Bipolar Disorders, 2025, vol. 13, num.26https://doi.org/10.1186/s40345-025-00392-9cc-by-nc-nd (c) Sommerhof, Constanza et al., 2025http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2239812026-05-29T05:05:01Z
dc.title.none.fl_str_mv The role of predominant polarity in older age bipolar disorder
title The role of predominant polarity in older age bipolar disorder
spellingShingle The role of predominant polarity in older age bipolar disorder
Sommerhof, Constanza
Trastorn bipolar
Persones grans
Manic-depressive illness
Older people
title_short The role of predominant polarity in older age bipolar disorder
title_full The role of predominant polarity in older age bipolar disorder
title_fullStr The role of predominant polarity in older age bipolar disorder
title_full_unstemmed The role of predominant polarity in older age bipolar disorder
title_sort The role of predominant polarity in older age bipolar disorder
dc.creator.none.fl_str_mv Sommerhof, Constanza
Bort, Marta
D’Alessandro, Giulia
Fico, Giovanna
De Prisco, Michele
Oliva, Vincenzo
Solé Cabezuelo, Brisa
Torrent Font, Carla
Murru, Andrea
Ruiz, Andrea
Rodríguez-Rey, Arturo
Sánchez-Moreno, José
Jiménez Martínez, Esther
Martínez-Arán, Anabel, 1971-
Vieta i Pascual, Eduard, 1963-
Montejo Egido, Laura
author Sommerhof, Constanza
author_facet Sommerhof, Constanza
Bort, Marta
D’Alessandro, Giulia
Fico, Giovanna
De Prisco, Michele
Oliva, Vincenzo
Solé Cabezuelo, Brisa
Torrent Font, Carla
Murru, Andrea
Ruiz, Andrea
Rodríguez-Rey, Arturo
Sánchez-Moreno, José
Jiménez Martínez, Esther
Martínez-Arán, Anabel, 1971-
Vieta i Pascual, Eduard, 1963-
Montejo Egido, Laura
author_role author
author2 Bort, Marta
D’Alessandro, Giulia
Fico, Giovanna
De Prisco, Michele
Oliva, Vincenzo
Solé Cabezuelo, Brisa
Torrent Font, Carla
Murru, Andrea
Ruiz, Andrea
Rodríguez-Rey, Arturo
Sánchez-Moreno, José
Jiménez Martínez, Esther
Martínez-Arán, Anabel, 1971-
Vieta i Pascual, Eduard, 1963-
Montejo Egido, Laura
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Trastorn bipolar
Persones grans
Manic-depressive illness
Older people
topic Trastorn bipolar
Persones grans
Manic-depressive illness
Older people
description Introduction: Predominant polarity (PP) has emerged as a valuable course specifier in bipolar disorder (BD) with implications for prognosis and treatment planning. As the BD population ages, understanding its clinical characteristics becomes essential to tailor personalized interventions across the lifespan. This study aimed to characterize the distribution and clinical profiles of PP subgroups in a cohort of older adults with BD (OABD). Methods: This cross-sectional study included 101 euthymic OABD aged >50 years. Clinical, neuropsychological and functional characteristics were compared between depressive (DPP), manic (MPP), and undetermined predominant polarity (UPP) subgroups, based on at least 2/3 of lifetime episodes being either depressive or manic polarity. Results: UPP was the most frequent PP in OABD (59.4%), followed by DPP (27.7%) and MPP (12.9%). Patients with DPP presented a later age of onset, a depressive first episode, less psychiatric hospitalizations, and a trend to outperform MPP and UPP in visual memory. Participants with MPP presented more frequently with manic onset. The UPP subgroup exhibited worse clinical outcomes, including higher number of total episodes, more frequent suicidal ideation and seasonality, and worse financial disability compared to DPP. Conclusion: PP classification distinguishes meaningful clinical and cognitive subgroups in OABD. The UPP subgroup associates with greater illness severity and functional impairment. These findings support the integration of PP into personalized treatment and prevention strategies in aging BD. Future longitudinal studies are needed to further clarify the trajectory of PP across the lifespan.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/223981
url https://hdl.handle.net/2445/223981
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1186/s40345-025-00392-9
International Journal of Bipolar Disorders, 2025, vol. 13, num.26
https://doi.org/10.1186/s40345-025-00392-9
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Sommerhof, Constanza et al., 2025
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Sommerhof, Constanza et al., 2025
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv Springer Open
publisher.none.fl_str_mv Springer Open
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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