Consensus paper: towards a systems-level view of cerebellar function: the interplay between cerebellum, basal ganglia, and cortex

Despite increasing evidence suggesting the cerebellum works in concert with the cortex and basal ganglia, the nature of the reciprocal interactions between these three brain regions remains unclear. This consensus paper gathers diverse recent views on a variety of important roles played by the cereb...

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Autores: Caligiore, Daniele, Pezzulo, Giovanni, Baldassarre, Gianluca, Bostan, Andreea C., Strick, Peter L., Doya, Kenji, Helmich, Rick C., Dirkx, Michiel, Houk, James, Jörntell, Henrik, Lago-Rodriguez, Angel, Galea, Joseph M., Miall, R. Chris, Popa, Traian, Kishore, Asha, Verschure, Paul F. M. J., Zucca, Riccardo, Herreros, Ivan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/57074
Acceso en línea:http://hdl.handle.net/10230/57074
http://dx.doi.org/10.1007/s12311-016-0763-3
Access Level:acceso abierto
Palabra clave:Basal ganglia cerebellum anatomical link
Nucleo-olivary inhibition
Movement disorders
Parkinson’s disease tremor
Cerebellar motor and cognitive function
Non-invasive brain stimulation
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dc.title.none.fl_str_mv Consensus paper: towards a systems-level view of cerebellar function: the interplay between cerebellum, basal ganglia, and cortex
title Consensus paper: towards a systems-level view of cerebellar function: the interplay between cerebellum, basal ganglia, and cortex
spellingShingle Consensus paper: towards a systems-level view of cerebellar function: the interplay between cerebellum, basal ganglia, and cortex
Caligiore, Daniele
Basal ganglia cerebellum anatomical link
Nucleo-olivary inhibition
Movement disorders
Parkinson’s disease tremor
Cerebellar motor and cognitive function
Non-invasive brain stimulation
title_short Consensus paper: towards a systems-level view of cerebellar function: the interplay between cerebellum, basal ganglia, and cortex
title_full Consensus paper: towards a systems-level view of cerebellar function: the interplay between cerebellum, basal ganglia, and cortex
title_fullStr Consensus paper: towards a systems-level view of cerebellar function: the interplay between cerebellum, basal ganglia, and cortex
title_full_unstemmed Consensus paper: towards a systems-level view of cerebellar function: the interplay between cerebellum, basal ganglia, and cortex
title_sort Consensus paper: towards a systems-level view of cerebellar function: the interplay between cerebellum, basal ganglia, and cortex
dc.creator.none.fl_str_mv Caligiore, Daniele
Pezzulo, Giovanni
Baldassarre, Gianluca
Bostan, Andreea C.
Strick, Peter L.
Doya, Kenji
Helmich, Rick C.
Dirkx, Michiel
Houk, James
Jörntell, Henrik
Lago-Rodriguez, Angel
Galea, Joseph M.
Miall, R. Chris
Popa, Traian
Kishore, Asha
Verschure, Paul F. M. J.
Zucca, Riccardo
Herreros, Ivan
author Caligiore, Daniele
author_facet Caligiore, Daniele
Pezzulo, Giovanni
Baldassarre, Gianluca
Bostan, Andreea C.
Strick, Peter L.
Doya, Kenji
Helmich, Rick C.
Dirkx, Michiel
Houk, James
Jörntell, Henrik
Lago-Rodriguez, Angel
Galea, Joseph M.
Miall, R. Chris
Popa, Traian
Kishore, Asha
Verschure, Paul F. M. J.
Zucca, Riccardo
Herreros, Ivan
author_role author
author2 Pezzulo, Giovanni
Baldassarre, Gianluca
Bostan, Andreea C.
Strick, Peter L.
Doya, Kenji
Helmich, Rick C.
Dirkx, Michiel
Houk, James
Jörntell, Henrik
Lago-Rodriguez, Angel
Galea, Joseph M.
Miall, R. Chris
Popa, Traian
Kishore, Asha
Verschure, Paul F. M. J.
Zucca, Riccardo
Herreros, Ivan
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Basal ganglia cerebellum anatomical link
Nucleo-olivary inhibition
Movement disorders
Parkinson’s disease tremor
Cerebellar motor and cognitive function
Non-invasive brain stimulation
topic Basal ganglia cerebellum anatomical link
Nucleo-olivary inhibition
Movement disorders
Parkinson’s disease tremor
Cerebellar motor and cognitive function
Non-invasive brain stimulation
description Despite increasing evidence suggesting the cerebellum works in concert with the cortex and basal ganglia, the nature of the reciprocal interactions between these three brain regions remains unclear. This consensus paper gathers diverse recent views on a variety of important roles played by the cerebellum within the cerebello-basal ganglia-thalamo-cortical system across a range of motor and cognitive functions. The paper includes theoretical and empirical contributions, which cover the following topics: recent evidence supporting the dynamical interplay between cerebellum, basal ganglia, and cortical areas in humans and other animals; theoretical neuroscience perspectives and empirical evidence on the reciprocal influences between cerebellum, basal ganglia, and cortex in learning and control processes; and data suggesting possible roles of the cerebellum in basal ganglia movement disorders. Although starting from different backgrounds and dealing with different topics, all the contributors agree that viewing the cerebellum, basal ganglia, and cortex as an integrated system enables us to understand the function of these areas in radically different ways. In addition, there is unanimous consensus between the authors that future experimental and computational work is needed to understand the function of cerebellar-basal ganglia circuitry in both motor and non-motor functions. The paper reports the most advanced perspectives on the role of the cerebellum within the cerebello-basal ganglia-thalamo-cortical system and illustrates other elements of consensus as well as disagreements and open questions in the field.
publishDate 2017
dc.date.none.fl_str_mv 2017
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/57074
http://dx.doi.org/10.1007/s12311-016-0763-3
url http://hdl.handle.net/10230/57074
http://dx.doi.org/10.1007/s12311-016-0763-3
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Cerebellum. 2017 Feb 1;16(1):203-29
info:eu-repo/grantAgreement/EC/FP7/231722
info:eu-repo/grantAgreement/EC/FP7/637488
info:eu-repo/grantAgreement/EC/FP7/341196
info:eu-repo/grantAgreement/EC/H2020/641321
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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spelling Consensus paper: towards a systems-level view of cerebellar function: the interplay between cerebellum, basal ganglia, and cortexCaligiore, DanielePezzulo, GiovanniBaldassarre, GianlucaBostan, Andreea C.Strick, Peter L.Doya, KenjiHelmich, Rick C.Dirkx, MichielHouk, JamesJörntell, HenrikLago-Rodriguez, AngelGalea, Joseph M.Miall, R. ChrisPopa, TraianKishore, AshaVerschure, Paul F. M. J.Zucca, RiccardoHerreros, IvanBasal ganglia cerebellum anatomical linkNucleo-olivary inhibitionMovement disordersParkinson’s disease tremorCerebellar motor and cognitive functionNon-invasive brain stimulationDespite increasing evidence suggesting the cerebellum works in concert with the cortex and basal ganglia, the nature of the reciprocal interactions between these three brain regions remains unclear. This consensus paper gathers diverse recent views on a variety of important roles played by the cerebellum within the cerebello-basal ganglia-thalamo-cortical system across a range of motor and cognitive functions. The paper includes theoretical and empirical contributions, which cover the following topics: recent evidence supporting the dynamical interplay between cerebellum, basal ganglia, and cortical areas in humans and other animals; theoretical neuroscience perspectives and empirical evidence on the reciprocal influences between cerebellum, basal ganglia, and cortex in learning and control processes; and data suggesting possible roles of the cerebellum in basal ganglia movement disorders. Although starting from different backgrounds and dealing with different topics, all the contributors agree that viewing the cerebellum, basal ganglia, and cortex as an integrated system enables us to understand the function of these areas in radically different ways. In addition, there is unanimous consensus between the authors that future experimental and computational work is needed to understand the function of cerebellar-basal ganglia circuitry in both motor and non-motor functions. The paper reports the most advanced perspectives on the role of the cerebellum within the cerebello-basal ganglia-thalamo-cortical system and illustrates other elements of consensus as well as disagreements and open questions in the field.The present research was supported by the European Commission 7th Framework Programme (FP7/2007-2013), “Challenge 2—Cognitive Systems, Interaction, Robotics,” grant agreement No. ICT IP-231722, project “IM-CLeVeR—Intrinsically Motivated Cumulative Learning Versatile Robots” to D. Caligiore; by the Human Frontier Science Program (HFSP), award number RGY0088/2014 to G. Pezzulo; in parts by funds from the Office of Research and Development, Medical Research Service, Department of Veterans Affairs and National Institutes of Health Grants R01 NS24328, R01 MH56661, P40 OD010996, and P30 NS076405 to P. L. Strick; by the European Research Council project MotMotLearn (637488) to J. Galea; by the MRC (grant R/J012610/1) to R.C. Miall and Wellcome Trust, grant WT087554 to R.C. Miall and A. Lago-Rodriguez; by the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement no. 341196 to P. F. M. J. Verschure; and by the European Commission’s Horizon 2020 socSMC (under agreement number socSMC-641321H2020-FETPROACT-2014) to I. Herreros. We thank the two anonymous reviewers and Professor Michael A. Arbib who have contributed to enhance the quality of this consensus paper with precious comments.Springer202320232017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/57074http://dx.doi.org/10.1007/s12311-016-0763-3reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésCerebellum. 2017 Feb 1;16(1):203-29info:eu-repo/grantAgreement/EC/FP7/231722info:eu-repo/grantAgreement/EC/FP7/637488info:eu-repo/grantAgreement/EC/FP7/341196info:eu-repo/grantAgreement/EC/H2020/641321This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/570742026-05-29T05:05:01Z
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