Expanded tracking of a Beijing Mycobacterium tuberculosis strain involved in an outbreak in France

14 páginas, 3 figuras, 1 tabla

Detalles Bibliográficos
Autores: Genestet, Charlotte, Perdigão, João, Herranz, Marta, Maus, Sandra R., Pérez Lago, Laura, Berland, Jean-Luc, Chiner-Oms, Álvaro, Comas, Iñaki, Muñoz, Patricia, Portugal, Isabel, Dumitrescu, Oana, García de Viedma, Darío
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/284037
Acceso en línea:http://hdl.handle.net/10261/284037
Access Level:acceso abierto
Palabra clave:Tuberculosis
Outbreak
Beijing
Cross-border
WGS
Strain-specific PCR
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spelling Expanded tracking of a Beijing Mycobacterium tuberculosis strain involved in an outbreak in FranceGenestet, CharlottePerdigão, JoãoHerranz, MartaMaus, Sandra R.Pérez Lago, LauraBerland, Jean-LucChiner-Oms, ÁlvaroComas, IñakiMuñoz, PatriciaPortugal, IsabelDumitrescu, OanaGarcía de Viedma, DaríoTuberculosisOutbreakBeijingCross-borderWGSStrain-specific PCR14 páginas, 3 figuras, 1 tablaAdvanced epidemiological surveillance supported on genomic epidemiology were necessary to fully describe a Mycobacterium tuberculosis Beijing strain (ARA, Auvergne-Rhône-Alpes region) outbreak in France. The index case was a migrant from Cape Verde with a two-year history of tuberculosis, high bacillary load, and frequent trips within France and to Portugal. We designed an ARA-specific PCR to complete the tracking of this outbreak strain. The ARA-specific PCR was applied on 160 Beijing isolates from independent cases from the Auvergne-Rhône-Alpes region and on 25 cases from Cape Verde migrants in the Île-de-France region. No more cases were found, indicating that the previous surveillance had been exhaustive enough to capture the whole dimension of the outbreak in France. Next, we performed a cross-border surveillance, applying the PCR on 38 Beijing isolates in Portuthe gal. In all four cases (all migrants from Cape Verde) the ARA strain was identified. Whole genome sequences analysis of all ARA isolates representatives indicated a diversification of the strain into two variants present one in France and one in PortugalThis work was supported by ERANet-LAC [ELAC2015/T08-0664] and Instituto de Salud Carlos III [AC16/00057, FIS15/01554, FIS13/ 01207, CP15/00075, PI16/01449, 1PI19/00331] and cofounded by European Regional Development Funds from the European Commission: “A way of making Europe”. Miguel Servet Contract CP15/00075 and CPII20/00001) to LPL. JP [CEECIND/00394/2017] is supported by FCT through Estímulo Individual ao Emprego Cientifico.Peer reviewedElsevierInstituto de Salud Carlos IIIEuropean CommissionComas, Iñaki [0000-0001-5504-9408]Chiner-Oms, Alvaro [0000-0002-0463-0101]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/284037reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO//AC16%2F00057https://dx.doi.org/10.1016/j.tmaid.2021.102167Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2840372026-05-22T06:33:51Z
dc.title.none.fl_str_mv Expanded tracking of a Beijing Mycobacterium tuberculosis strain involved in an outbreak in France
title Expanded tracking of a Beijing Mycobacterium tuberculosis strain involved in an outbreak in France
spellingShingle Expanded tracking of a Beijing Mycobacterium tuberculosis strain involved in an outbreak in France
Genestet, Charlotte
Tuberculosis
Outbreak
Beijing
Cross-border
WGS
Strain-specific PCR
title_short Expanded tracking of a Beijing Mycobacterium tuberculosis strain involved in an outbreak in France
title_full Expanded tracking of a Beijing Mycobacterium tuberculosis strain involved in an outbreak in France
title_fullStr Expanded tracking of a Beijing Mycobacterium tuberculosis strain involved in an outbreak in France
title_full_unstemmed Expanded tracking of a Beijing Mycobacterium tuberculosis strain involved in an outbreak in France
title_sort Expanded tracking of a Beijing Mycobacterium tuberculosis strain involved in an outbreak in France
dc.creator.none.fl_str_mv Genestet, Charlotte
Perdigão, João
Herranz, Marta
Maus, Sandra R.
Pérez Lago, Laura
Berland, Jean-Luc
Chiner-Oms, Álvaro
Comas, Iñaki
Muñoz, Patricia
Portugal, Isabel
Dumitrescu, Oana
García de Viedma, Darío
author Genestet, Charlotte
author_facet Genestet, Charlotte
Perdigão, João
Herranz, Marta
Maus, Sandra R.
Pérez Lago, Laura
Berland, Jean-Luc
Chiner-Oms, Álvaro
Comas, Iñaki
Muñoz, Patricia
Portugal, Isabel
Dumitrescu, Oana
García de Viedma, Darío
author_role author
author2 Perdigão, João
Herranz, Marta
Maus, Sandra R.
Pérez Lago, Laura
Berland, Jean-Luc
Chiner-Oms, Álvaro
Comas, Iñaki
Muñoz, Patricia
Portugal, Isabel
Dumitrescu, Oana
García de Viedma, Darío
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
European Commission
Comas, Iñaki [0000-0001-5504-9408]
Chiner-Oms, Alvaro [0000-0002-0463-0101]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Tuberculosis
Outbreak
Beijing
Cross-border
WGS
Strain-specific PCR
topic Tuberculosis
Outbreak
Beijing
Cross-border
WGS
Strain-specific PCR
description 14 páginas, 3 figuras, 1 tabla
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/284037
url http://hdl.handle.net/10261/284037
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO//AC16%2F00057
https://dx.doi.org/10.1016/j.tmaid.2021.102167
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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