Microflow nanoprecipitation of positively charged gastroresistant polymer nanoparticles of Eudragit® RS100: A study of fluid dynamics and chemical parameters

This article belongs to the Special Issue Advances in Microreactor Devices for Biomedicine, Nanoparticle Synthesis, Catalysis and Energy Processes.

Detalles Bibliográficos
Autores: Yus, Cristina, Arruebo, Manuel, Irusta, Silvia, Sebastián, Víctor
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/219032
Acceso en línea:http://hdl.handle.net/10261/219032
Access Level:acceso abierto
Palabra clave:Nanoparticles
Antibiotics
Nanoprecipitation
Micromixing
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dc.title.none.fl_str_mv Microflow nanoprecipitation of positively charged gastroresistant polymer nanoparticles of Eudragit® RS100: A study of fluid dynamics and chemical parameters
title Microflow nanoprecipitation of positively charged gastroresistant polymer nanoparticles of Eudragit® RS100: A study of fluid dynamics and chemical parameters
spellingShingle Microflow nanoprecipitation of positively charged gastroresistant polymer nanoparticles of Eudragit® RS100: A study of fluid dynamics and chemical parameters
Yus, Cristina
Nanoparticles
Antibiotics
Nanoprecipitation
Micromixing
title_short Microflow nanoprecipitation of positively charged gastroresistant polymer nanoparticles of Eudragit® RS100: A study of fluid dynamics and chemical parameters
title_full Microflow nanoprecipitation of positively charged gastroresistant polymer nanoparticles of Eudragit® RS100: A study of fluid dynamics and chemical parameters
title_fullStr Microflow nanoprecipitation of positively charged gastroresistant polymer nanoparticles of Eudragit® RS100: A study of fluid dynamics and chemical parameters
title_full_unstemmed Microflow nanoprecipitation of positively charged gastroresistant polymer nanoparticles of Eudragit® RS100: A study of fluid dynamics and chemical parameters
title_sort Microflow nanoprecipitation of positively charged gastroresistant polymer nanoparticles of Eudragit® RS100: A study of fluid dynamics and chemical parameters
dc.creator.none.fl_str_mv Yus, Cristina
Arruebo, Manuel
Irusta, Silvia
Sebastián, Víctor
author Yus, Cristina
author_facet Yus, Cristina
Arruebo, Manuel
Irusta, Silvia
Sebastián, Víctor
author_role author
author2 Arruebo, Manuel
Irusta, Silvia
Sebastián, Víctor
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
European Commission
Instituto de Salud Carlos III
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Nanoparticles
Antibiotics
Nanoprecipitation
Micromixing
topic Nanoparticles
Antibiotics
Nanoprecipitation
Micromixing
description This article belongs to the Special Issue Advances in Microreactor Devices for Biomedicine, Nanoparticle Synthesis, Catalysis and Energy Processes.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/219032
url http://hdl.handle.net/10261/219032
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-099019-A-I00
RTI2018-099019-A-I00/AEI/10.13039/501100011033
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/CTQ2017-84473-R
CTQ2017-84473-R/AEI/10.13039/501100011033
https://doi.org/10.3390/ma13132925
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
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spelling Microflow nanoprecipitation of positively charged gastroresistant polymer nanoparticles of Eudragit® RS100: A study of fluid dynamics and chemical parametersYus, CristinaArruebo, ManuelIrusta, SilviaSebastián, VíctorNanoparticlesAntibioticsNanoprecipitationMicromixingThis article belongs to the Special Issue Advances in Microreactor Devices for Biomedicine, Nanoparticle Synthesis, Catalysis and Energy Processes.The objective of the present work was to produce gastroresistant Eudragit® RS100 nanoparticles by a reproducible synthesis approach that ensured mono-disperse nanoparticles under the size of 100 nm. Batch and micromixing nanoprecipitation approaches were selected to produce the demanded nanoparticles, identifying the critical parameters affecting the synthesis process. To shed some light on the formulation of the targeted nanoparticles, the effects of particle size and homogeneity of fluid dynamics, and physicochemical parameters such as polymer concentration, type of solvent, ratio of solvent to antisolvent, and total flow rate were studied. The physicochemical characteristics of resulting nanoparticles were studied applying dynamic light scattering (DLS) particle size analysis and electron microscopy imaging. Nanoparticles produced using a micromixer demonstrated a narrower and more homogenous distribution than the ones obtained under similar conditions in conventional batch reactors. Besides, fluid dynamics ensured that the best mixing conditions were achieved at the highest flow rate. It was concluded that nucleation and growth events must also be considered to avoid uncontrolled nanoparticle growth and evolution at the collection vial. Further, rifampicin-encapsulated nanoparticles were prepared using both approaches, demonstrating that the micromixing-assisted approach provided an excellent control of the particle size and polydispersity index. Not only the micromixing-assisted nanoprecipitation promoted a remarkable control in the nanoparticle formulation, but also it enhanced drug encapsulation efficiency and loading, as well as productivity. To the best of our knowledge, this was the very first time that drug-loaded Eudragit® RS100 nanoparticles (NPs) were produced in a continuous fashion under 100 nm (16.5 ± 4.3 nm) using microreactor technology. Furthermore, we performed a detailed analysis of the influence of various fluid dynamics and physicochemical parameters on the size and uniformity of the resulting nanoparticles. According to these findings, the proposed methodology can be a useful approach to synthesize a myriad of nanoparticles of alternative polymers.Financial support from Ministerio de Ciencia, Innovación y Universidades, Programa Retos Investigación, Proyecto REF: RTI2018-099019-A-I00 is gratefully acknowledged. This research was also funded by the Spanish Ministry of Economy and Competitiveness (grant number CTQ2017-84473-R). CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008–2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III (Spain) with assistance from the European Regional Development Fund.Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)European CommissionInstituto de Salud Carlos IIIConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202020info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/219032reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-099019-A-I00RTI2018-099019-A-I00/AEI/10.13039/501100011033info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/CTQ2017-84473-RCTQ2017-84473-R/AEI/10.13039/501100011033https://doi.org/10.3390/ma13132925Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2190322026-05-22T06:33:51Z
score 15,81155

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