Electroporation and peripheral nerve stimulation

This thesis aimed at addressing questions within the fields of electroporation and peripheral nerve stimulation and, in particular, those that arise from the interaction between the two phenomenona. On the one hand, electroporation can have various direct and indirect effects in the neuronal functio...

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Detalles Bibliográficos
Autor: Mercadal Cavaller, Borja
Tipo de recurso: tesis doctoral
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:CBUC, CESCA
Repositorio:TDR. Tesis Doctorales en Red
OAI Identifier:oai:www.tdx.cat:10803/667854
Acceso en línea:http://hdl.handle.net/10803/667854
Access Level:acceso abierto
Palabra clave:Electroporation
Electrical stimulation
Neuromuscular
Irreversible electroporation
Bipolar pulses
High-Frequency irreversible electroporation
Pulsed radiofrequency
Intramuscular stimulation
62
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spelling Electroporation and peripheral nerve stimulationMercadal Cavaller, BorjaElectroporationElectrical stimulationNeuromuscularIrreversible electroporationBipolar pulsesHigh-Frequency irreversible electroporationPulsed radiofrequencyIntramuscular stimulation62This thesis aimed at addressing questions within the fields of electroporation and peripheral nerve stimulation and, in particular, those that arise from the interaction between the two phenomenona. On the one hand, electroporation can have various direct and indirect effects in the neuronal functions. This thesis investigates the possible role of electroporation in pulsed radiofrequency treatments for chronic pain. On the other hand, during electroporation based treatments, electrical stimulation of peripheral nerves appears as an unwanted effect causing muscle contractions and acute pain. This thesis analyzes the rationale behind the use of bipolar pulses to mitigate this effect and the implications of such approach in irreversible electroporation treatments. In addition, this thesis provides a theoretical framework to explain a series of results that were in apparent contradiction with the common knowledge of the electroporation phenomenon. Finally, this thesis presents a neuromuscular model to study the recruitment patterns in intramuscular electrical stimulation.Aquesta tesi té com a objectiu resoldre qüestions en els camps de l’electroporació i l’estimulació dels nervis perifèrics, i sobretot, aquelles que es deriven de l’interacció entre els dos fenòmens. L’electroporació pot tenir diversos efectes directes o indirectes en les funcions neuronals. En aquesta tesi s’investiga el possible paper de l’electroporació en els tractaments de radiofreqüència polsada. D’altra banda, durant els tractaments basats en l’electroporació, l’estimulació elèctrica dels nervis perifèrics apareix com a efecte secundari causant contraccions musculars i dolor. En aquesta tesi s’analitza com l’ús de polsos bipolar pot mitigar aquests efectes i quines implicacions té aquesta estratègia en els tractaments d’electroporació irreversible. En aquesta tesi també es presenta un marc teòric per explicar una sèrie de resultats que entren en aparent contradicció amb els nostres coneixements sobre l’electroporació. Finalment, es presenta un model neuromuscular que permet estudiar la resposta d’un múscul quan és estimulat mitjançant elèctrodes intramusculars.Programa de doctorat en Tecnologies de la Informació i les ComunicacionsUniversitat Pompeu FabraIvorra Cano, AntoniUniversitat Pompeu Fabra. Departament de Tecnologies de la Informació i les Comunicacions201920202019info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersion168 p.application/pdfapplication/pdfhttp://hdl.handle.net/10803/667854TDX (Tesis Doctorals en Xarxa)reponame:TDR. Tesis Doctorales en Redinstname:CBUC, CESCAInglésL'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc-sa/4.0/http://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessoai:www.tdx.cat:10803/6678542026-06-14T12:46:07Z
dc.title.none.fl_str_mv Electroporation and peripheral nerve stimulation
title Electroporation and peripheral nerve stimulation
spellingShingle Electroporation and peripheral nerve stimulation
Mercadal Cavaller, Borja
Electroporation
Electrical stimulation
Neuromuscular
Irreversible electroporation
Bipolar pulses
High-Frequency irreversible electroporation
Pulsed radiofrequency
Intramuscular stimulation
62
title_short Electroporation and peripheral nerve stimulation
title_full Electroporation and peripheral nerve stimulation
title_fullStr Electroporation and peripheral nerve stimulation
title_full_unstemmed Electroporation and peripheral nerve stimulation
title_sort Electroporation and peripheral nerve stimulation
dc.creator.none.fl_str_mv Mercadal Cavaller, Borja
author Mercadal Cavaller, Borja
author_facet Mercadal Cavaller, Borja
author_role author
dc.contributor.none.fl_str_mv Ivorra Cano, Antoni
Universitat Pompeu Fabra. Departament de Tecnologies de la Informació i les Comunicacions
dc.subject.none.fl_str_mv Electroporation
Electrical stimulation
Neuromuscular
Irreversible electroporation
Bipolar pulses
High-Frequency irreversible electroporation
Pulsed radiofrequency
Intramuscular stimulation
62
topic Electroporation
Electrical stimulation
Neuromuscular
Irreversible electroporation
Bipolar pulses
High-Frequency irreversible electroporation
Pulsed radiofrequency
Intramuscular stimulation
62
description This thesis aimed at addressing questions within the fields of electroporation and peripheral nerve stimulation and, in particular, those that arise from the interaction between the two phenomenona. On the one hand, electroporation can have various direct and indirect effects in the neuronal functions. This thesis investigates the possible role of electroporation in pulsed radiofrequency treatments for chronic pain. On the other hand, during electroporation based treatments, electrical stimulation of peripheral nerves appears as an unwanted effect causing muscle contractions and acute pain. This thesis analyzes the rationale behind the use of bipolar pulses to mitigate this effect and the implications of such approach in irreversible electroporation treatments. In addition, this thesis provides a theoretical framework to explain a series of results that were in apparent contradiction with the common knowledge of the electroporation phenomenon. Finally, this thesis presents a neuromuscular model to study the recruitment patterns in intramuscular electrical stimulation.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
info:eu-repo/semantics/publishedVersion
format doctoralThesis
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10803/667854
url http://hdl.handle.net/10803/667854
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 168 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universitat Pompeu Fabra
publisher.none.fl_str_mv Universitat Pompeu Fabra
dc.source.none.fl_str_mv TDX (Tesis Doctorals en Xarxa)
reponame:TDR. Tesis Doctorales en Red
instname:CBUC, CESCA
instname_str CBUC, CESCA
reponame_str TDR. Tesis Doctorales en Red
collection TDR. Tesis Doctorales en Red
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869417329482268672
score 15.300719

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