Impact of the functional CD5 polymorphism A471V on the response of chronic lymphocytic leukaemia to conventional chemotherapy regimens.

Chronic lymphocytic leukaemia (CLL) represents an abnormal clonal expansion of mature antigen-experienced CD5+ B1a cells (Chiorazzi et al, 2005), which present with a highly heterogeneous clinical course depending on associated chromosomal aberrations, somatic mutations within the immunoglobulin var...

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Bibliographic Details
Authors: Delgado, Julio (Delgado González), Bielig, Torsten, Bonet, Lizette, Carnero Montoro, Elena, Puente, Xose S., Colomer Pujol, Dolors, Bosch, Elena, Campo Güerri, Elias, Lozano Soto, Francisco
Format: article
Status:Versión enviada para evaluación y publicación
Publication Date:2016
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/107804
Online Access:https://hdl.handle.net/2445/107804
Access Level:Open access
Keyword:Leucèmia limfocítica crònica
Receptors cel·lulars
Cèl·lules B
Biologia molecular
Immunologia
Chronic lymphocytic leukemia
Cell receptors
B cells
Molecular biology
Immunology
Description
Summary:Chronic lymphocytic leukaemia (CLL) represents an abnormal clonal expansion of mature antigen-experienced CD5+ B1a cells (Chiorazzi et al, 2005), which present with a highly heterogeneous clinical course depending on associated chromosomal aberrations, somatic mutations within the immunoglobulin variable heavy chain genes (IGHV), and surface CD38 or intracytoplasmic ZAP-70 expression. Given that key signalling components of the B-cell receptor (BCR) are relevant contributors to the variable clinical behaviour of CLL (Stevenson et al, 2011) we explored the influence of functionally relevant germline CD5 variants on CLL prognosis.

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