Muscular echovariation: a new biomarker in amyotrophic lateral sclerosis

The purpose is to assess the characteristics of echovariation in amyotrophic lateral sclerosis (ALS) compared with other MUS parameters. Twenty-six ALS patients (8 women, mean age 58.9 years, SD 12.02 yr) and 26 healthy controls (17 women; mean age 59.6 years, SD 6.41 yr) were included in this obser...

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Detalles Bibliográficos
Autor: Martínez Payá, Jacinto Javier
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universidad Católica San Antonio de Murcia (UCAM)
Repositorio:RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia
OAI Identifier:oai:repositorio.ucam.edu:10952/2281
Acceso en línea:http://hdl.handle.net/10952/2281
Access Level:acceso abierto
Palabra clave:Clinical neurology examination
Observational study
Ultrasound
Amyotrophic lateral sclerosis
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spelling Muscular echovariation: a new biomarker in amyotrophic lateral sclerosisMartínez Payá, Jacinto JavierClinical neurology examinationObservational studyUltrasoundAmyotrophic lateral sclerosisThe purpose is to assess the characteristics of echovariation in amyotrophic lateral sclerosis (ALS) compared with other MUS parameters. Twenty-six ALS patients (8 women, mean age 58.9 years, SD 12.02 yr) and 26 healthy controls (17 women; mean age 59.6 years, SD 6.41 yr) were included in this observational study. They underwent bilateral and transverse ultrasound of the biceps/brachialis, forearm flexor group, quadriceps femoris and tibialis anterior. Muscular thickness, echointensity and echovariation were analyzed. Muscles affected by ALS showed increased echointensity, decrease in thickness, and decrease echovariation. Echovariation in all muscles but quadriceps femoris, strongly correlated with muscle strength (explained variance between 21.8% in the biceps/brachialis and 37.5% in tibialis anterior) and the ALSFRS-R score (explained variance between 26% in the biceps/brachialis and 36.7% in the forearm flexor group). Echovariation is an easy to obtain QMUS parameter that could distinguish ALS from healthy controls more accurately than previous described biomarkers.UCAMMedicinaTerapia y RehabilitaciónElsevierdel Baño-Aledo, María ElenaRíos-Díaz, JoséTembl-Ferrairó, José IgnacioVázquez-Costa, Juan FranciscoMedina-Mirapeix, Francesc2017info:eu-repo/semantics/articlehttp://hdl.handle.net/10952/2281reponame:RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murciainstname:Universidad Católica San Antonio de Murcia (UCAM)Inglésinfo:eu-repo/semantics/openAccessoai:repositorio.ucam.edu:10952/22812026-06-07T18:35:21Z
dc.title.none.fl_str_mv Muscular echovariation: a new biomarker in amyotrophic lateral sclerosis
title Muscular echovariation: a new biomarker in amyotrophic lateral sclerosis
spellingShingle Muscular echovariation: a new biomarker in amyotrophic lateral sclerosis
Martínez Payá, Jacinto Javier
Clinical neurology examination
Observational study
Ultrasound
Amyotrophic lateral sclerosis
title_short Muscular echovariation: a new biomarker in amyotrophic lateral sclerosis
title_full Muscular echovariation: a new biomarker in amyotrophic lateral sclerosis
title_fullStr Muscular echovariation: a new biomarker in amyotrophic lateral sclerosis
title_full_unstemmed Muscular echovariation: a new biomarker in amyotrophic lateral sclerosis
title_sort Muscular echovariation: a new biomarker in amyotrophic lateral sclerosis
dc.creator.none.fl_str_mv Martínez Payá, Jacinto Javier
author Martínez Payá, Jacinto Javier
author_facet Martínez Payá, Jacinto Javier
author_role author
dc.contributor.none.fl_str_mv del Baño-Aledo, María Elena
Ríos-Díaz, José
Tembl-Ferrairó, José Ignacio
Vázquez-Costa, Juan Francisco
Medina-Mirapeix, Francesc
dc.subject.none.fl_str_mv Clinical neurology examination
Observational study
Ultrasound
Amyotrophic lateral sclerosis
topic Clinical neurology examination
Observational study
Ultrasound
Amyotrophic lateral sclerosis
description The purpose is to assess the characteristics of echovariation in amyotrophic lateral sclerosis (ALS) compared with other MUS parameters. Twenty-six ALS patients (8 women, mean age 58.9 years, SD 12.02 yr) and 26 healthy controls (17 women; mean age 59.6 years, SD 6.41 yr) were included in this observational study. They underwent bilateral and transverse ultrasound of the biceps/brachialis, forearm flexor group, quadriceps femoris and tibialis anterior. Muscular thickness, echointensity and echovariation were analyzed. Muscles affected by ALS showed increased echointensity, decrease in thickness, and decrease echovariation. Echovariation in all muscles but quadriceps femoris, strongly correlated with muscle strength (explained variance between 21.8% in the biceps/brachialis and 37.5% in tibialis anterior) and the ALSFRS-R score (explained variance between 26% in the biceps/brachialis and 36.7% in the forearm flexor group). Echovariation is an easy to obtain QMUS parameter that could distinguish ALS from healthy controls more accurately than previous described biomarkers.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10952/2281
url http://hdl.handle.net/10952/2281
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia
instname:Universidad Católica San Antonio de Murcia (UCAM)
instname_str Universidad Católica San Antonio de Murcia (UCAM)
reponame_str RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia
collection RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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