HDR and LDR brachytherapy in the treatment of lip cancer: the experience of the Catalan Institute of Oncology

Purpose: lip cancer can be treated by surgery, external radiotherapy, and/or brachytherapy (BT). In recent years, BT has become increasingly favored for this type of cancer. The aim of the present study was to analyze local control and survival of patients treated at our institution between July 198...

Descripción completa

Detalles Bibliográficos
Autores: Querejeta Ayerra, Arrate, Palacios Mena, Estefanía, Pera Fàbregas, Joan, Gutiérrez Miguélez, Cristina, Guedea Edo, Ferran
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/177207
Acceso en línea:https://hdl.handle.net/2445/177207
Access Level:acceso abierto
Palabra clave:Braquiteràpia
Càncer de boca
Llavis
Radioteràpia
Radioisotope brachytherapy
Oral cancer
Lips
Radiotherapy
id ES_b4e4e10d5037571eeb8fd132514ae252
oai_identifier_str oai:diposit.ub.edu:2445/177207
network_acronym_str ES
network_name_str España
repository_id_str
spelling HDR and LDR brachytherapy in the treatment of lip cancer: the experience of the Catalan Institute of OncologyQuerejeta Ayerra, ArratePalacios Mena, EstefaníaPera Fàbregas, JoanGutiérrez Miguélez, CristinaGuedea Edo, FerranBraquiteràpiaCàncer de bocaLlavisRadioteràpiaRadioisotope brachytherapyOral cancerLipsRadiotherapyPurpose: lip cancer can be treated by surgery, external radiotherapy, and/or brachytherapy (BT). In recent years, BT has become increasingly favored for this type of cancer. The aim of the present study was to analyze local control and survival of patients treated at our institution between July 1989 and June 2008. Material and methods: we performed a retrospective study of 121 patients (109 males and 12 females) who underwent lip cancer brachytherapy from July 1989 to June 2008. Median age was 67 years and median follow-up was 31.8 months (range 20-188 months). Out of 121 patients, 100 (82.6%) were treated with low dose rate (LDR) BT while the remaining 21 patients (17.4%) received high dose rate (HDR) BT. Results: the most common cell type was squamous cell carcinoma (115 cases; 95%) and most tumors were located on the lower lip (107 patients; 88.4%). Most cases were either stage T1 (62 patients; 51.2%), or T2 (44 cases; 36.4%). After 15 years of follow-up, overall survival was 89.5%, cause-specific survival 97.8%, and disease-free survival 86.6%. Local, regional, and distant control at 15 years were 90%, 92%, and 98.8%, respectively. Grade 3 mucosal toxicity was observed in 23% of patients treated with LDR compared to 33% of HDR patients, and grade 4 mucosal toxicity in 9% versus 0% in the HDR group. Conclusions: our findings confirm that brachytherapy is an effective treatment for lip cancer. The results from our series are in line with those published elsewhere. Based on our limited data, HDR appears to be equally as good as LDR, although this needs to be confirmed by further studies.Polish Brachytherapy Society2010info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/177207Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.5114/jcb.2010.13717Journal of Contemporary Brachytherapy, 2010, vol. 2, num. 1, p. 9-13https://doi.org/10.5114/jcb.2010.13717(c) Polish Brachytherapy Society, 2010info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1772072026-05-27T06:46:51Z
dc.title.none.fl_str_mv HDR and LDR brachytherapy in the treatment of lip cancer: the experience of the Catalan Institute of Oncology
title HDR and LDR brachytherapy in the treatment of lip cancer: the experience of the Catalan Institute of Oncology
spellingShingle HDR and LDR brachytherapy in the treatment of lip cancer: the experience of the Catalan Institute of Oncology
Querejeta Ayerra, Arrate
Braquiteràpia
Càncer de boca
Llavis
Radioteràpia
Radioisotope brachytherapy
Oral cancer
Lips
Radiotherapy
title_short HDR and LDR brachytherapy in the treatment of lip cancer: the experience of the Catalan Institute of Oncology
title_full HDR and LDR brachytherapy in the treatment of lip cancer: the experience of the Catalan Institute of Oncology
title_fullStr HDR and LDR brachytherapy in the treatment of lip cancer: the experience of the Catalan Institute of Oncology
title_full_unstemmed HDR and LDR brachytherapy in the treatment of lip cancer: the experience of the Catalan Institute of Oncology
title_sort HDR and LDR brachytherapy in the treatment of lip cancer: the experience of the Catalan Institute of Oncology
dc.creator.none.fl_str_mv Querejeta Ayerra, Arrate
Palacios Mena, Estefanía
Pera Fàbregas, Joan
Gutiérrez Miguélez, Cristina
Guedea Edo, Ferran
author Querejeta Ayerra, Arrate
author_facet Querejeta Ayerra, Arrate
Palacios Mena, Estefanía
Pera Fàbregas, Joan
Gutiérrez Miguélez, Cristina
Guedea Edo, Ferran
author_role author
author2 Palacios Mena, Estefanía
Pera Fàbregas, Joan
Gutiérrez Miguélez, Cristina
Guedea Edo, Ferran
author2_role author
author
author
author
dc.subject.none.fl_str_mv Braquiteràpia
Càncer de boca
Llavis
Radioteràpia
Radioisotope brachytherapy
Oral cancer
Lips
Radiotherapy
topic Braquiteràpia
Càncer de boca
Llavis
Radioteràpia
Radioisotope brachytherapy
Oral cancer
Lips
Radiotherapy
description Purpose: lip cancer can be treated by surgery, external radiotherapy, and/or brachytherapy (BT). In recent years, BT has become increasingly favored for this type of cancer. The aim of the present study was to analyze local control and survival of patients treated at our institution between July 1989 and June 2008. Material and methods: we performed a retrospective study of 121 patients (109 males and 12 females) who underwent lip cancer brachytherapy from July 1989 to June 2008. Median age was 67 years and median follow-up was 31.8 months (range 20-188 months). Out of 121 patients, 100 (82.6%) were treated with low dose rate (LDR) BT while the remaining 21 patients (17.4%) received high dose rate (HDR) BT. Results: the most common cell type was squamous cell carcinoma (115 cases; 95%) and most tumors were located on the lower lip (107 patients; 88.4%). Most cases were either stage T1 (62 patients; 51.2%), or T2 (44 cases; 36.4%). After 15 years of follow-up, overall survival was 89.5%, cause-specific survival 97.8%, and disease-free survival 86.6%. Local, regional, and distant control at 15 years were 90%, 92%, and 98.8%, respectively. Grade 3 mucosal toxicity was observed in 23% of patients treated with LDR compared to 33% of HDR patients, and grade 4 mucosal toxicity in 9% versus 0% in the HDR group. Conclusions: our findings confirm that brachytherapy is an effective treatment for lip cancer. The results from our series are in line with those published elsewhere. Based on our limited data, HDR appears to be equally as good as LDR, although this needs to be confirmed by further studies.
publishDate 2010
dc.date.none.fl_str_mv 2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/177207
url https://hdl.handle.net/2445/177207
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.5114/jcb.2010.13717
Journal of Contemporary Brachytherapy, 2010, vol. 2, num. 1, p. 9-13
https://doi.org/10.5114/jcb.2010.13717
dc.rights.none.fl_str_mv (c) Polish Brachytherapy Society, 2010
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Polish Brachytherapy Society, 2010
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Polish Brachytherapy Society
publisher.none.fl_str_mv Polish Brachytherapy Society
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869417298137186304
score 15,300724

Similares en LA Referencia