Myeloid-derived suppressor cells limit the inflammation by promoting T lymphocyte apoptosis in the spinal cord of a murine model of multiple sclerosis.

Moliné-Velázquez, Verónica; Cuervo, Henar; Vila-Del Sol, Virginia; Ortega, María Cristina; Clemente, Diego; de Castro, Fernando

Myeloid-derived suppressor cells limit the inflammation by promoting T lymphocyte apoptosis in the spinal cord of a murine model of multiple sclerosis.

Multiple Sclerosis (MS) is a demyelinating/inflammatory disease of the central nervous system. Relapsing-remitting MS is characterized by a relapsing phase with clinical symptoms and the production of inflammatory cell infiltrates, and a period of remission during which patients recover partially. M...

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Detalles Bibliográficos
Autores:	Moliné-Velázquez, Verónica, Cuervo, Henar, Vila-Del Sol, Virginia, Ortega, María Cristina, Clemente, Diego, de Castro, Fernando
Tipo de recurso:	artículo
Fecha de publicación:	2011
País:	España
Institución:	Instituto de Salud Carlos III (ISCIII)
Repositorio:	Repisalud
Idioma:	inglés
OAI Identifier:	oai:repisalud.isciii.es:20.500.12105/17194
Acceso en línea:	http://hdl.handle.net/20.500.12105/17194
Access Level:	acceso abierto
Palabra clave:	Animals Apoptosis Arginase Encephalomyelitis, Autoimmune, Experimental Female Immune Tolerance Immunohistochemistry Inflammation Mice Mice, Inbred C57BL Multiple Sclerosis, Relapsing-Remitting Myeloid Cells Spinal Cord T-Lymphocytes

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spelling	Myeloid-derived suppressor cells limit the inflammation by promoting T lymphocyte apoptosis in the spinal cord of a murine model of multiple sclerosis.Moliné-Velázquez, VerónicaCuervo, HenarVila-Del Sol, VirginiaOrtega, María CristinaClemente, Diegode Castro, FernandoAnimalsApoptosisArginaseEncephalomyelitis, Autoimmune, ExperimentalFemaleImmune ToleranceImmunohistochemistryInflammationMiceMice, Inbred C57BLMultiple Sclerosis, Relapsing-RemittingMyeloid CellsSpinal CordT-LymphocytesMultiple Sclerosis (MS) is a demyelinating/inflammatory disease of the central nervous system. Relapsing-remitting MS is characterized by a relapsing phase with clinical symptoms and the production of inflammatory cell infiltrates, and a period of remission during which patients recover partially. Myeloid-derived suppressor cells (MDSCs) are immature cells capable of suppressing the inflammatory response through Arginase-I (Arg-I) activity, among other mechanisms. Here, we have identified Arg-I(+) -MDSCs in the spinal cord during experimental autoimmune encephalomyelitis (EAE), cells that were largely restricted to the demyelinating plaque and that always exhibited the characteristic MDSC surface markers Arg-I/CD11b/Gr-1/M-CSF1R. The presence and density of Arg-I(+) -cells, and the proportion of apoptotic but not proliferative T cells, were correlated with the EAE time course: peaked in parallel with the clinical score, decreased significantly during the remitting phase and completely disappeared during the chronic phase. Spinal cord-isolated MDSCs of EAE animals augmented the cell death when co-cultured with stimulated control splenic CD3 T cells. These data point to an important role for MDSCs in limiting inflammatory damage in MS, favoring the relative recovery in the remitting phase of the disease. Thus, the MDSC population should be considered as a potential therapeutic target to accelerate the recovery of MS patients.Wiley20242024-01-1720112011-11-0120112011-11-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/17194reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/171942026-06-12T12:43:37Z
dc.title.none.fl_str_mv	Myeloid-derived suppressor cells limit the inflammation by promoting T lymphocyte apoptosis in the spinal cord of a murine model of multiple sclerosis.
title	Myeloid-derived suppressor cells limit the inflammation by promoting T lymphocyte apoptosis in the spinal cord of a murine model of multiple sclerosis.
spellingShingle	Myeloid-derived suppressor cells limit the inflammation by promoting T lymphocyte apoptosis in the spinal cord of a murine model of multiple sclerosis. Moliné-Velázquez, Verónica Animals Apoptosis Arginase Encephalomyelitis, Autoimmune, Experimental Female Immune Tolerance Immunohistochemistry Inflammation Mice Mice, Inbred C57BL Multiple Sclerosis, Relapsing-Remitting Myeloid Cells Spinal Cord T-Lymphocytes
title_short	Myeloid-derived suppressor cells limit the inflammation by promoting T lymphocyte apoptosis in the spinal cord of a murine model of multiple sclerosis.
title_full	Myeloid-derived suppressor cells limit the inflammation by promoting T lymphocyte apoptosis in the spinal cord of a murine model of multiple sclerosis.
title_fullStr	Myeloid-derived suppressor cells limit the inflammation by promoting T lymphocyte apoptosis in the spinal cord of a murine model of multiple sclerosis.
title_full_unstemmed	Myeloid-derived suppressor cells limit the inflammation by promoting T lymphocyte apoptosis in the spinal cord of a murine model of multiple sclerosis.
title_sort	Myeloid-derived suppressor cells limit the inflammation by promoting T lymphocyte apoptosis in the spinal cord of a murine model of multiple sclerosis.
dc.creator.none.fl_str_mv	Moliné-Velázquez, Verónica Cuervo, Henar Vila-Del Sol, Virginia Ortega, María Cristina Clemente, Diego de Castro, Fernando
author	Moliné-Velázquez, Verónica
author_facet	Moliné-Velázquez, Verónica Cuervo, Henar Vila-Del Sol, Virginia Ortega, María Cristina Clemente, Diego de Castro, Fernando
author_role	author
author2	Cuervo, Henar Vila-Del Sol, Virginia Ortega, María Cristina Clemente, Diego de Castro, Fernando
author2_role	author author author author author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv	Animals Apoptosis Arginase Encephalomyelitis, Autoimmune, Experimental Female Immune Tolerance Immunohistochemistry Inflammation Mice Mice, Inbred C57BL Multiple Sclerosis, Relapsing-Remitting Myeloid Cells Spinal Cord T-Lymphocytes
topic	Animals Apoptosis Arginase Encephalomyelitis, Autoimmune, Experimental Female Immune Tolerance Immunohistochemistry Inflammation Mice Mice, Inbred C57BL Multiple Sclerosis, Relapsing-Remitting Myeloid Cells Spinal Cord T-Lymphocytes
description	Multiple Sclerosis (MS) is a demyelinating/inflammatory disease of the central nervous system. Relapsing-remitting MS is characterized by a relapsing phase with clinical symptoms and the production of inflammatory cell infiltrates, and a period of remission during which patients recover partially. Myeloid-derived suppressor cells (MDSCs) are immature cells capable of suppressing the inflammatory response through Arginase-I (Arg-I) activity, among other mechanisms. Here, we have identified Arg-I(+) -MDSCs in the spinal cord during experimental autoimmune encephalomyelitis (EAE), cells that were largely restricted to the demyelinating plaque and that always exhibited the characteristic MDSC surface markers Arg-I/CD11b/Gr-1/M-CSF1R. The presence and density of Arg-I(+) -cells, and the proportion of apoptotic but not proliferative T cells, were correlated with the EAE time course: peaked in parallel with the clinical score, decreased significantly during the remitting phase and completely disappeared during the chronic phase. Spinal cord-isolated MDSCs of EAE animals augmented the cell death when co-cultured with stimulated control splenic CD3 T cells. These data point to an important role for MDSCs in limiting inflammatory damage in MS, favoring the relative recovery in the remitting phase of the disease. Thus, the MDSC population should be considered as a potential therapeutic target to accelerate the recovery of MS patients.
publishDate	2011
dc.date.none.fl_str_mv	2011 2011-11-01 2011 2011-11-01 2024 2024-01-17
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	http://hdl.handle.net/20.500.12105/17194
url	http://hdl.handle.net/20.500.12105/17194
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Wiley
publisher.none.fl_str_mv	Wiley
dc.source.none.fl_str_mv	reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII)
instname_str	Instituto de Salud Carlos III (ISCIII)
reponame_str	Repisalud
collection	Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,812429

Myeloid-derived suppressor cells limit the inflammation by promoting T lymphocyte apoptosis in the spinal cord of a murine model of multiple sclerosis.

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