Tumour characteristics and survivorship in a cohort of breast cancer
The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological prognostic...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:227747 |
| Acceso en línea: | https://ddd.uab.cat/record/227747 https://dx.doi.org/urn:doi:10.1007/s10549-020-05600-x |
| Access Level: | acceso abierto |
| Palabra clave: | Cohort Epidemiology Breast cancer Relative survival MCC-spain |
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oai:ddd.uab.cat:227747 |
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España |
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| dc.title.none.fl_str_mv |
Tumour characteristics and survivorship in a cohort of breast cancer the MCC-Spain study |
| title |
Tumour characteristics and survivorship in a cohort of breast cancer |
| spellingShingle |
Tumour characteristics and survivorship in a cohort of breast cancer Gomez-Acebo, Ines|||0000-0001-8793-8314 Cohort Epidemiology Breast cancer Relative survival MCC-spain |
| title_short |
Tumour characteristics and survivorship in a cohort of breast cancer |
| title_full |
Tumour characteristics and survivorship in a cohort of breast cancer |
| title_fullStr |
Tumour characteristics and survivorship in a cohort of breast cancer |
| title_full_unstemmed |
Tumour characteristics and survivorship in a cohort of breast cancer |
| title_sort |
Tumour characteristics and survivorship in a cohort of breast cancer |
| dc.creator.none.fl_str_mv |
Gomez-Acebo, Ines|||0000-0001-8793-8314 Dierssen-Sotos, Trinidad|||0000-0002-6127-0077 Palazuelos-Calderón, Camilo Pérez-Gómez, Beatriz|||0000-0002-4299-8214 Amiano, Pilar Guevara, Marcela|||0000-0001-9242-6364 Molina de la Torre, Antonio José Domingo, Laia|||0000-0003-4420-0891 Fernández-Ortiz, María|||0000-0003-0017-875X Moreno Aguado, Victor Raul|||0000-0002-2818-5487 Alguacil, Juan|||0000-0003-2703-9725 Fernández-Tardon, Guillermo|||0000-0002-7680-158X Ibáñez, Josefa Marcos-Gragera, Rafael|||0000-0001-9824-3657 Diaz-Santos, Marian Alonso, M. Henar Alonso Molero, Jessica|||0000-0002-1939-8798 Castaño-Vinyals, Gemma|||0000-0003-4468-1816 García Palomo, Andrés|||0000-0002-9159-9025 Ardanaz, Eva Molinuevo, Amaia Aragonés, Nuria Kogevinas, Manolis|||0000-0002-9605-0461 Pollán, Marina|||0000-0002-4328-1565 Llorca, Javier|||0000-0001-8569-861X |
| author |
Gomez-Acebo, Ines|||0000-0001-8793-8314 |
| author_facet |
Gomez-Acebo, Ines|||0000-0001-8793-8314 Dierssen-Sotos, Trinidad|||0000-0002-6127-0077 Palazuelos-Calderón, Camilo Pérez-Gómez, Beatriz|||0000-0002-4299-8214 Amiano, Pilar Guevara, Marcela|||0000-0001-9242-6364 Molina de la Torre, Antonio José Domingo, Laia|||0000-0003-4420-0891 Fernández-Ortiz, María|||0000-0003-0017-875X Moreno Aguado, Victor Raul|||0000-0002-2818-5487 Alguacil, Juan|||0000-0003-2703-9725 Fernández-Tardon, Guillermo|||0000-0002-7680-158X Ibáñez, Josefa Marcos-Gragera, Rafael|||0000-0001-9824-3657 Diaz-Santos, Marian Alonso, M. Henar Alonso Molero, Jessica|||0000-0002-1939-8798 Castaño-Vinyals, Gemma|||0000-0003-4468-1816 García Palomo, Andrés|||0000-0002-9159-9025 Ardanaz, Eva Molinuevo, Amaia Aragonés, Nuria Kogevinas, Manolis|||0000-0002-9605-0461 Pollán, Marina|||0000-0002-4328-1565 Llorca, Javier|||0000-0001-8569-861X |
| author_role |
author |
| author2 |
Dierssen-Sotos, Trinidad|||0000-0002-6127-0077 Palazuelos-Calderón, Camilo Pérez-Gómez, Beatriz|||0000-0002-4299-8214 Amiano, Pilar Guevara, Marcela|||0000-0001-9242-6364 Molina de la Torre, Antonio José Domingo, Laia|||0000-0003-4420-0891 Fernández-Ortiz, María|||0000-0003-0017-875X Moreno Aguado, Victor Raul|||0000-0002-2818-5487 Alguacil, Juan|||0000-0003-2703-9725 Fernández-Tardon, Guillermo|||0000-0002-7680-158X Ibáñez, Josefa Marcos-Gragera, Rafael|||0000-0001-9824-3657 Diaz-Santos, Marian Alonso, M. Henar Alonso Molero, Jessica|||0000-0002-1939-8798 Castaño-Vinyals, Gemma|||0000-0003-4468-1816 García Palomo, Andrés|||0000-0002-9159-9025 Ardanaz, Eva Molinuevo, Amaia Aragonés, Nuria Kogevinas, Manolis|||0000-0002-9605-0461 Pollán, Marina|||0000-0002-4328-1565 Llorca, Javier|||0000-0001-8569-861X |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Cohort Epidemiology Breast cancer Relative survival MCC-spain |
| topic |
Cohort Epidemiology Breast cancer Relative survival MCC-spain |
| description |
The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological prognostic score. The breast cancer MCC-Spain follow-up study is a prospective cohort study of 1685 incident breast cancer cases. Women between 20 and 85 years old were recruited between the years 2008 and 2013 in 18 hospitals located in 10 Spanish provinces and they have been followed until 2017/2018. Relative survival was estimated after 3, 5 and 8 years of follow-up using Ederer II method. In addition, Weibull regression adjusted by age, hospital, grade and stage was used to investigate prognosis factors. Among components of TNM staging system, tumour size greater than 50 mm (i.e. T3 or T4) more than doubled the risk of dying, while N3 nodal involvement and presence of metastasis had a huge effect on mortality. The AJCC pathological prognostic score strongly correlated with survival; thus, hazard ratios increased as the score rose, being 2.31, 4.00, 4.94, 7.92, 2.26, 14.9 and 58.9 for scores IB, IIA, IIB, IIIA, IIIB, IIIC and IV, respectively. Both TNM staging and histological/molecular biomarkers are associated with overall survival in Spanish women with breast cancer; when both are combined in the AJCC pathological prognosis score, the prognostic value improved with risk indices that increased rapidly as the pathological prognosis score increased The online version of this article (10.1007/s10549-020-05600-x) contains supplementary material, which is available to authorised users. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2 2020-01-01 2020 2020-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/227747 https://dx.doi.org/urn:doi:10.1007/s10549-020-05600-x |
| url |
https://ddd.uab.cat/record/227747 https://dx.doi.org/urn:doi:10.1007/s10549-020-05600-x |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI08/1770 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI08/0533 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI08/1359 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI09/00773 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI09/01286 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI09/01903 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI09/02078 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI09/01662 Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PI11/01403 Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PI11/01889 Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PI11/00226 Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PI11/01810 Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PI11/02213 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI12/00488 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI12/00265 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI12/01270 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI12/00715 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI12/00150 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI14/01219 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI14/00613 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI15/00069 European Commission https://doi.org/10.13039/501100000780 036224 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2014/SGR-647 |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Tumour characteristics and survivorship in a cohort of breast cancerthe MCC-Spain studyGomez-Acebo, Ines|||0000-0001-8793-8314Dierssen-Sotos, Trinidad|||0000-0002-6127-0077Palazuelos-Calderón, CamiloPérez-Gómez, Beatriz|||0000-0002-4299-8214Amiano, PilarGuevara, Marcela|||0000-0001-9242-6364Molina de la Torre, Antonio JoséDomingo, Laia|||0000-0003-4420-0891Fernández-Ortiz, María|||0000-0003-0017-875XMoreno Aguado, Victor Raul|||0000-0002-2818-5487Alguacil, Juan|||0000-0003-2703-9725Fernández-Tardon, Guillermo|||0000-0002-7680-158XIbáñez, JosefaMarcos-Gragera, Rafael|||0000-0001-9824-3657Diaz-Santos, MarianAlonso, M. HenarAlonso Molero, Jessica|||0000-0002-1939-8798Castaño-Vinyals, Gemma|||0000-0003-4468-1816García Palomo, Andrés|||0000-0002-9159-9025Ardanaz, EvaMolinuevo, AmaiaAragonés, NuriaKogevinas, Manolis|||0000-0002-9605-0461Pollán, Marina|||0000-0002-4328-1565Llorca, Javier|||0000-0001-8569-861XCohortEpidemiologyBreast cancerRelative survivalMCC-spainThe objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological prognostic score. The breast cancer MCC-Spain follow-up study is a prospective cohort study of 1685 incident breast cancer cases. Women between 20 and 85 years old were recruited between the years 2008 and 2013 in 18 hospitals located in 10 Spanish provinces and they have been followed until 2017/2018. Relative survival was estimated after 3, 5 and 8 years of follow-up using Ederer II method. In addition, Weibull regression adjusted by age, hospital, grade and stage was used to investigate prognosis factors. Among components of TNM staging system, tumour size greater than 50 mm (i.e. T3 or T4) more than doubled the risk of dying, while N3 nodal involvement and presence of metastasis had a huge effect on mortality. The AJCC pathological prognostic score strongly correlated with survival; thus, hazard ratios increased as the score rose, being 2.31, 4.00, 4.94, 7.92, 2.26, 14.9 and 58.9 for scores IB, IIA, IIB, IIIA, IIIB, IIIC and IV, respectively. Both TNM staging and histological/molecular biomarkers are associated with overall survival in Spanish women with breast cancer; when both are combined in the AJCC pathological prognosis score, the prognostic value improved with risk indices that increased rapidly as the pathological prognosis score increased The online version of this article (10.1007/s10549-020-05600-x) contains supplementary material, which is available to authorised users.Universitat Autònoma de Barcelona 22020-01-0120202020-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/227747https://dx.doi.org/urn:doi:10.1007/s10549-020-05600-xreponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI08/1770Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI08/0533Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI08/1359Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI09/00773Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI09/01286Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI09/01903Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI09/02078Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI09/01662Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PI11/01403Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PI11/01889Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PI11/00226Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PI11/01810Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PI11/02213Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI12/00488Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI12/00265Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI12/01270Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI12/00715Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI12/00150Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI14/01219Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI14/00613Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI15/00069European Commission https://doi.org/10.13039/501100000780 036224Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2014/SGR-647open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2277472026-06-06T12:50:31Z |
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15,300724 |