Analysis of 60 pharmaceuticals and personal care products in sewage sludge by ultra-high performance liquid chromatography and tandem mass spectroscopy

Producción Científica

Detalles Bibliográficos
Autores: Pérez Lemus, Nereida, López Serna, Rebeca, Pérez Elvira, Sara Isabel, Barrado Esteban, Enrique
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2022
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/51372
Acceso en línea:https://doi.org/10.1016/j.microc.2021.107148
https://uvadoc.uva.es/handle/10324/51372
Access Level:acceso abierto
Palabra clave:LC-MS/MS
Compounds of emerging concern (CECs)
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spelling Analysis of 60 pharmaceuticals and personal care products in sewage sludge by ultra-high performance liquid chromatography and tandem mass spectroscopyPérez Lemus, NereidaLópez Serna, RebecaPérez Elvira, Sara IsabelBarrado Esteban, EnriqueLC-MS/MSCompounds of emerging concern (CECs)Producción CientíficaThis paper presents a comparison of three different analytical proposals for the determination of 60 pharmaceuticals and personal care products (PPCPs) in solid urban sewage sludge. Two fast sample pretreatments, i.e., online solid-phase-extraction (online SPE) and direct injection (DI), were tested against the conventional offline solid phase extraction (offline SPE). In all cases, subsequently, extracts underwent ultra-high-performance-liquid chromatography coupled to tandem-mass-spectrometry (UHPLC-MS/MS), simultaneously operating in both positive and negative electrospray ionization (ESI) mode. In addition, as solid matrices, clean-up steps were necessarily preceded by ultra-sound-assisted extraction (UAE) in all cases. Matrix-matched quantification was combined with internal standard providing high reliability to all three approaches. Best performance was observed for the fully automatized and non-pretreated DI method, showing limits of detection below 30 ng g-1 for many of the target compounds, and recoveries between 80 and 120%. Finally, the best working method was validated and applied to the analysis of PPCPs in different dewatered digested sludge samples from the wastewater treatment plant (WWTP) in Valladolid (Spain). Acetaminophen was found at concentrations above 1,000 ng g-1.This work was supported by the University of Valladolid (UVa) through its General Foundation (063/136391), by the Spanish Government (MINECO-CTM2015-70722-R) and by the Regional Government of Castilla y León and the EU-FEDER (CLU 2017–09, UIC 071, INFRARED2018-UVA3, and VA080G18). It was partially carried out in the Laboratory of Instrumental Techniques from the UVa. The UVa is also recognized for the postdoctoral contract held by Rebeca López Serna (2018POSTDOC UVA12).Elsevier2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://doi.org/10.1016/j.microc.2021.107148https://uvadoc.uva.es/handle/10324/51372reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://www.sciencedirect.com/science/article/pii/S0026265X21012340?via%3Dihubinfo:eu-repo/semantics/openAccessoai:uvadoc.uva.es:10324/513722026-06-13T12:44:47Z
dc.title.none.fl_str_mv Analysis of 60 pharmaceuticals and personal care products in sewage sludge by ultra-high performance liquid chromatography and tandem mass spectroscopy
title Analysis of 60 pharmaceuticals and personal care products in sewage sludge by ultra-high performance liquid chromatography and tandem mass spectroscopy
spellingShingle Analysis of 60 pharmaceuticals and personal care products in sewage sludge by ultra-high performance liquid chromatography and tandem mass spectroscopy
Pérez Lemus, Nereida
LC-MS/MS
Compounds of emerging concern (CECs)
title_short Analysis of 60 pharmaceuticals and personal care products in sewage sludge by ultra-high performance liquid chromatography and tandem mass spectroscopy
title_full Analysis of 60 pharmaceuticals and personal care products in sewage sludge by ultra-high performance liquid chromatography and tandem mass spectroscopy
title_fullStr Analysis of 60 pharmaceuticals and personal care products in sewage sludge by ultra-high performance liquid chromatography and tandem mass spectroscopy
title_full_unstemmed Analysis of 60 pharmaceuticals and personal care products in sewage sludge by ultra-high performance liquid chromatography and tandem mass spectroscopy
title_sort Analysis of 60 pharmaceuticals and personal care products in sewage sludge by ultra-high performance liquid chromatography and tandem mass spectroscopy
dc.creator.none.fl_str_mv Pérez Lemus, Nereida
López Serna, Rebeca
Pérez Elvira, Sara Isabel
Barrado Esteban, Enrique
author Pérez Lemus, Nereida
author_facet Pérez Lemus, Nereida
López Serna, Rebeca
Pérez Elvira, Sara Isabel
Barrado Esteban, Enrique
author_role author
author2 López Serna, Rebeca
Pérez Elvira, Sara Isabel
Barrado Esteban, Enrique
author2_role author
author
author
dc.subject.none.fl_str_mv LC-MS/MS
Compounds of emerging concern (CECs)
topic LC-MS/MS
Compounds of emerging concern (CECs)
description Producción Científica
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1016/j.microc.2021.107148
https://uvadoc.uva.es/handle/10324/51372
url https://doi.org/10.1016/j.microc.2021.107148
https://uvadoc.uva.es/handle/10324/51372
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.sciencedirect.com/science/article/pii/S0026265X21012340?via%3Dihub
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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