Building a network of TP53 and IGHV testing reference centers across Spain: the Red53 initiative

© The Author(s) 2021.

Detalles Bibliográficos
Autores: Bosch, Francesc, Navarro, Blanca, Crespo, Marta, Alcoceba, Miguel, Bravo Sánchez, Julio, Tazón‐Vega, Bárbara, Serrano, Alicia, García-Alvarez, María, González Serrano, Lydia, Alonso-Torres, Pablo, Villanueva, Miguel, Loriente, Cristina, Abrisqueta, Pau, Peiró, Manel, García-Marco, José A., González, Marcos, Terol, María José
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/261123
Acceso en línea:http://hdl.handle.net/10261/261123
Access Level:acceso abierto
Palabra clave:CLL
IGHV mutational status
TP53 gene mutations
Laboratory network
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spelling Building a network of TP53 and IGHV testing reference centers across Spain: the Red53 initiativeBosch, FrancescNavarro, BlancaCrespo, MartaAlcoceba, MiguelBravo Sánchez, JulioTazón‐Vega, BárbaraSerrano, AliciaGarcía-Alvarez, MaríaGonzález Serrano, LydiaAlonso-Torres, PabloVillanueva, MiguelLoriente, CristinaAbrisqueta, PauPeiró, ManelGarcía-Marco, José A.González, MarcosTerol, María JoséCLLIGHV mutational statusTP53 gene mutationsLaboratory network© The Author(s) 2021.Among the different biomarkers predicting response in chronic lymphocytic leukemia (CLL), the most influential parameters are the mutational status of the IGHV genes and the presence of TP53 gene disruptions. Nevertheless, these important assessments are not readily available in most centers dealing with CLL patients. To provide this molecular testing across the country, the Spanish Cooperative Group on CLL (GELLC) established a network of four analytical reference centers. A total of 2153 samples from 256 centers were analyzed over a period of 30 months. In 9% of the patients, we found pathological mutations in the TP53 gene, whereas 48.96% were classified as IGHV unmutated. Results of the satisfaction survey of the program showed a Net Promoter Score of 85.15. Building a national network for molecular testing in CLL allowed the CLL population a broad access to complex biomarkers analysis that should translate into a more accurate and informed therapeutic decision-making.This work was supported in part by Janssen Pharmaceutical Companies of Johnson & Johnson. MC holds a contract from Ministerio de Ciencia, Innovación y Universidades (RYC-2012-12018).Springer NatureJanssen BiotechJohnson and Johnson Pharmaceutical Research and DevelopmentMinisterio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220212022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/261123reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO//RYC-2012-12018http://dx.doi.org/10.1007/s00277-020-04331-9Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2611232026-05-22T06:33:51Z
dc.title.none.fl_str_mv Building a network of TP53 and IGHV testing reference centers across Spain: the Red53 initiative
title Building a network of TP53 and IGHV testing reference centers across Spain: the Red53 initiative
spellingShingle Building a network of TP53 and IGHV testing reference centers across Spain: the Red53 initiative
Bosch, Francesc
CLL
IGHV mutational status
TP53 gene mutations
Laboratory network
title_short Building a network of TP53 and IGHV testing reference centers across Spain: the Red53 initiative
title_full Building a network of TP53 and IGHV testing reference centers across Spain: the Red53 initiative
title_fullStr Building a network of TP53 and IGHV testing reference centers across Spain: the Red53 initiative
title_full_unstemmed Building a network of TP53 and IGHV testing reference centers across Spain: the Red53 initiative
title_sort Building a network of TP53 and IGHV testing reference centers across Spain: the Red53 initiative
dc.creator.none.fl_str_mv Bosch, Francesc
Navarro, Blanca
Crespo, Marta
Alcoceba, Miguel
Bravo Sánchez, Julio
Tazón‐Vega, Bárbara
Serrano, Alicia
García-Alvarez, María
González Serrano, Lydia
Alonso-Torres, Pablo
Villanueva, Miguel
Loriente, Cristina
Abrisqueta, Pau
Peiró, Manel
García-Marco, José A.
González, Marcos
Terol, María José
author Bosch, Francesc
author_facet Bosch, Francesc
Navarro, Blanca
Crespo, Marta
Alcoceba, Miguel
Bravo Sánchez, Julio
Tazón‐Vega, Bárbara
Serrano, Alicia
García-Alvarez, María
González Serrano, Lydia
Alonso-Torres, Pablo
Villanueva, Miguel
Loriente, Cristina
Abrisqueta, Pau
Peiró, Manel
García-Marco, José A.
González, Marcos
Terol, María José
author_role author
author2 Navarro, Blanca
Crespo, Marta
Alcoceba, Miguel
Bravo Sánchez, Julio
Tazón‐Vega, Bárbara
Serrano, Alicia
García-Alvarez, María
González Serrano, Lydia
Alonso-Torres, Pablo
Villanueva, Miguel
Loriente, Cristina
Abrisqueta, Pau
Peiró, Manel
García-Marco, José A.
González, Marcos
Terol, María José
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Janssen Biotech
Johnson and Johnson Pharmaceutical Research and Development
Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv CLL
IGHV mutational status
TP53 gene mutations
Laboratory network
topic CLL
IGHV mutational status
TP53 gene mutations
Laboratory network
description © The Author(s) 2021.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/261123
url http://hdl.handle.net/10261/261123
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO//RYC-2012-12018
http://dx.doi.org/10.1007/s00277-020-04331-9
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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