PLA and PBAT-Based Electrospun Fibers Functionalized with Antibacterial Bio-Based Polymers
Antimicrobial fibers based on biodegradable polymers, poly(lactic acid) (PLA),and poly(butylene adipate-co-terephthalate) (PBAT) are prepared byelectrospinning. For this purpose, a biodegradable/bio-based polyitaconatecontaining azoles groups (PTTI) is incorporated at 10 wt.% into theelectrospinning...
| Autores: | , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/329625 |
| Acceso en línea: | http://hdl.handle.net/10261/329625 |
| Access Level: | acceso abierto |
| Palabra clave: | Antimicrobial fibers Cell viability Cytostatic effect Electrospinning Poly(lactic) acid |
| Sumario: | Antimicrobial fibers based on biodegradable polymers, poly(lactic acid) (PLA),and poly(butylene adipate-co-terephthalate) (PBAT) are prepared byelectrospinning. For this purpose, a biodegradable/bio-based polyitaconatecontaining azoles groups (PTTI) is incorporated at 10 wt.% into theelectrospinning formulations. The resulting fibers functionalized with azolemoieties are uniform and free of beads. Then, the accessible azole groups aresubjected toN-alkylation, treatment that provides cationic azolium groupswith antibacterial activity at the surface of fibers. The positive charge density,roughness, and wettability of the cationic fibers are evaluated and comparedwith flat films. It is confirmed that these parameters exert an important effecton the antimicrobial properties, as well as the length of the alkylating agentand the hydrophobicity of the matrix. The quaternized PLA/PTTI fibers exhibitthe highest efficiency against the tested bacteria, yielding a 4-Log reductionagainstS. aureusand 1.7-Log against MRSA. Then, biocompatibility andbioactivity of the fibers are evaluated in terms of adhesion, morphology andviability of fibroblasts. The results show no cytotoxic effect of the samples,however, a cytostatic effect is appreciated, which is ascribed to the strongelectrostatic interactions between the positive charge at the fiber surface andthe negative charge of the cell membranes |
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