Hierarchical Hybrid Coatings with Drug-Eluting Capacity for Mg Alloy Biomaterials

A hierarchical hybrid coating (HHC) comprising a ceramic oxide layer and two biodegradable polymeric (polycaprolactone, PCL) layers has been developed on Mg3Zn0.4Ca cast alloy in order to provide a controlled degradation rate and functionality by creating a favorable porous surface topography for ce...

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Detalhes bibliográficos
Autores: Nicolao-Gómez, Ana, Martínez-Campos, Enrique, Moreno, Lara, Rodríguez-Hernández, Juan, Matykina, Endzhe
Tipo de documento: conjunto de datos
Data de publicação:2023
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositório:Docta Complutense
Idioma:inglês
OAI Identifier:oai:docta.ucm.es:20.500.14352/91841
Acesso em linha:https://hdl.handle.net/20.500.14352/91841
Access Level:Acceso aberto
Palavra-chave:620
Magnesium
Implant
Plasma electrolytic oxidation
Polycaprolactone
Corrosion
Drug delivery
Materiales
2407.01 Cultivo Celular
3303.07 Tecnología de la Corrosión
3303.10 Recubrimiento Por Electrólisis
2206.10 Polímeros
2211.01 Aleaciones
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spelling Hierarchical Hybrid Coatings with Drug-Eluting Capacity for Mg Alloy BiomaterialsNicolao-Gómez, AnaMartínez-Campos, EnriqueMoreno, LaraRodríguez-Hernández, JuanMatykina, Endzhe620MagnesiumImplantPlasma electrolytic oxidationPolycaprolactoneCorrosionDrug deliveryMateriales2407.01 Cultivo Celular3303.07 Tecnología de la Corrosión3303.10 Recubrimiento Por Electrólisis2206.10 Polímeros2211.01 AleacionesA hierarchical hybrid coating (HHC) comprising a ceramic oxide layer and two biodegradable polymeric (polycaprolactone, PCL) layers has been developed on Mg3Zn0.4Ca cast alloy in order to provide a controlled degradation rate and functionality by creating a favorable porous surface topography for cell adhesion. The inner, ceramic layer formed by plasma electrolytic oxidation (PEO) has been enriched in bioactive elements (Ca, P, Si). The intermediate PCL layer sealed the defect in the PEO layer and the outer microporous PCL layer loaded with the appropriate active molecule, thus providing drug-eluting capacity. Morphological, chemical, and biological characterizations of the manufactured coatings loaded with ciprofloxacin (CIP) and paracetamol (PAR) have been carried out. In vitro assays with cell lines relevant for cardiovascular implants and bone prosthesis (endothelial cells and premyoblasts) showed that the drug-loaded coating allows for cell proliferation and viability. The study of CIP and PAR cytotoxicity and release rate indicated that the porous PCL layer does not release concentrations detrimental to the cells. However, complete system assays revealed that corrosion behavior and increase of the pH negatively affects cell viability. H2 evolution during corrosion of Mg alloy substrate generates blisters in PCL layer that accelerate the corrosion locally in crevice microenvironment. A detailed mechanism of the system degradation is disclosed. The accelerated degradation of the developed system may present interest for its further adaptation to new cancer therapy strategies.MDPIUniversidad Complutense de Madrid20232023-01-0120232023-01-01datasethttp://purl.org/coar/resource_type/c_ddb1AOhttp://purl.org/coar/version/c_b1a7d7d4d402bcceinfo:eu-repo/semantics/datasetapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/vnd.openxmlformats-officedocument.presentationml.presentationapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheetapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheetapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheetapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheetapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheetapplication/vnd.openxmlformats-officedocument.spreadsheetml.sheethttps://hdl.handle.net/20.500.14352/91841reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/918412026-06-02T12:44:21Z
dc.title.none.fl_str_mv Hierarchical Hybrid Coatings with Drug-Eluting Capacity for Mg Alloy Biomaterials
title Hierarchical Hybrid Coatings with Drug-Eluting Capacity for Mg Alloy Biomaterials
spellingShingle Hierarchical Hybrid Coatings with Drug-Eluting Capacity for Mg Alloy Biomaterials
Nicolao-Gómez, Ana
620
Magnesium
Implant
Plasma electrolytic oxidation
Polycaprolactone
Corrosion
Drug delivery
Materiales
2407.01 Cultivo Celular
3303.07 Tecnología de la Corrosión
3303.10 Recubrimiento Por Electrólisis
2206.10 Polímeros
2211.01 Aleaciones
title_short Hierarchical Hybrid Coatings with Drug-Eluting Capacity for Mg Alloy Biomaterials
title_full Hierarchical Hybrid Coatings with Drug-Eluting Capacity for Mg Alloy Biomaterials
title_fullStr Hierarchical Hybrid Coatings with Drug-Eluting Capacity for Mg Alloy Biomaterials
title_full_unstemmed Hierarchical Hybrid Coatings with Drug-Eluting Capacity for Mg Alloy Biomaterials
title_sort Hierarchical Hybrid Coatings with Drug-Eluting Capacity for Mg Alloy Biomaterials
dc.creator.none.fl_str_mv Nicolao-Gómez, Ana
Martínez-Campos, Enrique
Moreno, Lara
Rodríguez-Hernández, Juan
Matykina, Endzhe
author Nicolao-Gómez, Ana
author_facet Nicolao-Gómez, Ana
Martínez-Campos, Enrique
Moreno, Lara
Rodríguez-Hernández, Juan
Matykina, Endzhe
author_role author
author2 Martínez-Campos, Enrique
Moreno, Lara
Rodríguez-Hernández, Juan
Matykina, Endzhe
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 620
Magnesium
Implant
Plasma electrolytic oxidation
Polycaprolactone
Corrosion
Drug delivery
Materiales
2407.01 Cultivo Celular
3303.07 Tecnología de la Corrosión
3303.10 Recubrimiento Por Electrólisis
2206.10 Polímeros
2211.01 Aleaciones
topic 620
Magnesium
Implant
Plasma electrolytic oxidation
Polycaprolactone
Corrosion
Drug delivery
Materiales
2407.01 Cultivo Celular
3303.07 Tecnología de la Corrosión
3303.10 Recubrimiento Por Electrólisis
2206.10 Polímeros
2211.01 Aleaciones
description A hierarchical hybrid coating (HHC) comprising a ceramic oxide layer and two biodegradable polymeric (polycaprolactone, PCL) layers has been developed on Mg3Zn0.4Ca cast alloy in order to provide a controlled degradation rate and functionality by creating a favorable porous surface topography for cell adhesion. The inner, ceramic layer formed by plasma electrolytic oxidation (PEO) has been enriched in bioactive elements (Ca, P, Si). The intermediate PCL layer sealed the defect in the PEO layer and the outer microporous PCL layer loaded with the appropriate active molecule, thus providing drug-eluting capacity. Morphological, chemical, and biological characterizations of the manufactured coatings loaded with ciprofloxacin (CIP) and paracetamol (PAR) have been carried out. In vitro assays with cell lines relevant for cardiovascular implants and bone prosthesis (endothelial cells and premyoblasts) showed that the drug-loaded coating allows for cell proliferation and viability. The study of CIP and PAR cytotoxicity and release rate indicated that the porous PCL layer does not release concentrations detrimental to the cells. However, complete system assays revealed that corrosion behavior and increase of the pH negatively affects cell viability. H2 evolution during corrosion of Mg alloy substrate generates blisters in PCL layer that accelerate the corrosion locally in crevice microenvironment. A detailed mechanism of the system degradation is disclosed. The accelerated degradation of the developed system may present interest for its further adaptation to new cancer therapy strategies.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv dataset
http://purl.org/coar/resource_type/c_ddb1
AO
http://purl.org/coar/version/c_b1a7d7d4d402bcce
dc.type.openaire.fl_str_mv info:eu-repo/semantics/dataset
format dataset
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/91841
url https://hdl.handle.net/20.500.14352/91841
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/vnd.openxmlformats-officedocument.wordprocessingml.document
application/vnd.openxmlformats-officedocument.wordprocessingml.document
application/vnd.openxmlformats-officedocument.presentationml.presentation
application/vnd.openxmlformats-officedocument.spreadsheetml.sheet
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dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
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repository.mail.fl_str_mv
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