Pollution induces epigenetic effects that are stably transmitted across multiple generations

18 pages, 7 figures, 3 tables, supporting Information https://doi.org/10.1002/evl3.273.-- Data archiving: Genomic data has been deposited at the European Nucleotide Archive (ENA: https://www.ebi.ac.uk/ena) with the project accession PRJEB47706. Phenotypic data and processed genomic data, together wi...

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Authors: Harney, Ewan, Paterson, Steve, Collin, Hélène, Chan, Brian H.K., Bennett, Daimark, Plaistow, Stewart J.
Format: article
Status:Published version
Publication Date:2022
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/269575
Online Access:http://hdl.handle.net/10261/269575
Access Level:Open access
Keyword:Cytosine methylation
Daphnia pulex
Ecotoxicology
Gene body methylation
Transgenerational epigenetic inheritance
id ES_b4b3f005b16f6765d088d2dcbafc3a25
oai_identifier_str oai:digital.csic.es:10261/269575
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Pollution induces epigenetic effects that are stably transmitted across multiple generations
title Pollution induces epigenetic effects that are stably transmitted across multiple generations
spellingShingle Pollution induces epigenetic effects that are stably transmitted across multiple generations
Harney, Ewan
Cytosine methylation
Daphnia pulex
Ecotoxicology
Gene body methylation
Transgenerational epigenetic inheritance
title_short Pollution induces epigenetic effects that are stably transmitted across multiple generations
title_full Pollution induces epigenetic effects that are stably transmitted across multiple generations
title_fullStr Pollution induces epigenetic effects that are stably transmitted across multiple generations
title_full_unstemmed Pollution induces epigenetic effects that are stably transmitted across multiple generations
title_sort Pollution induces epigenetic effects that are stably transmitted across multiple generations
dc.creator.none.fl_str_mv Harney, Ewan
Paterson, Steve
Collin, Hélène
Chan, Brian H.K.
Bennett, Daimark
Plaistow, Stewart J.
author Harney, Ewan
author_facet Harney, Ewan
Paterson, Steve
Collin, Hélène
Chan, Brian H.K.
Bennett, Daimark
Plaistow, Stewart J.
author_role author
author2 Paterson, Steve
Collin, Hélène
Chan, Brian H.K.
Bennett, Daimark
Plaistow, Stewart J.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Natural Environment Research Council (UK)
Agencia Estatal de Investigación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Cytosine methylation
Daphnia pulex
Ecotoxicology
Gene body methylation
Transgenerational epigenetic inheritance
topic Cytosine methylation
Daphnia pulex
Ecotoxicology
Gene body methylation
Transgenerational epigenetic inheritance
description 18 pages, 7 figures, 3 tables, supporting Information https://doi.org/10.1002/evl3.273.-- Data archiving: Genomic data has been deposited at the European Nucleotide Archive (ENA: https://www.ebi.ac.uk/ena) with the project accession PRJEB47706. Phenotypic data and processed genomic data, together with R scripts for their analysis, have been deposited at Dryad (https://doi.org/10.5061/dryad.h9w0vt4k9)
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/269575
url http://hdl.handle.net/10261/269575
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Harney, Ewan; Paterson, Steve; Collin, Hélène; Chan, Brian H.K.; Bennett, Daimark; Plaistow, Stewart J.; 2022; Pollution induces epigenetic effects that are stably transmitted across multiple generations [Dataset]; Dryad; https://doi.org/10.5061/dryad.h9w0vt4k9
Harney, Ewan; Paterson, Steve; Collin, Hélène; Chan, Brian H.K; Bennett, Daimark; Plaistow, Stewart J.; 2022; Pollution induces epigenetic effects that are stably transmitted across multiple generations [Software]; Zenodo; Version 1; https://doi.org/10.5281/zenodo.5926900
https://doi.org/10.1002/evl3.273
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Society for the Study of Evolution
publisher.none.fl_str_mv Society for the Study of Evolution
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Pollution induces epigenetic effects that are stably transmitted across multiple generationsHarney, EwanPaterson, SteveCollin, HélèneChan, Brian H.K.Bennett, DaimarkPlaistow, Stewart J.Cytosine methylationDaphnia pulexEcotoxicologyGene body methylationTransgenerational epigenetic inheritance18 pages, 7 figures, 3 tables, supporting Information https://doi.org/10.1002/evl3.273.-- Data archiving: Genomic data has been deposited at the European Nucleotide Archive (ENA: https://www.ebi.ac.uk/ena) with the project accession PRJEB47706. Phenotypic data and processed genomic data, together with R scripts for their analysis, have been deposited at Dryad (https://doi.org/10.5061/dryad.h9w0vt4k9)It has been hypothesized that the effects of pollutants on phenotypes can be passed to subsequent generations through epigenetic inheritance, affecting populations long after the removal of a pollutant. But there is still little evidence that pollutants can induce persistent epigenetic effects in animals. Here, we show that low doses of commonly used pollutants induce genome-wide differences in cytosine methylation in the freshwater crustacean Daphnia pulex. Uniclonal populations were either continually exposed to pollutants or switched to clean water, and methylation was compared to control populations that did not experience pollutant exposure. Although some direct changes to methylation were only present in the continually exposed populations, others were present in both the continually exposed and switched to clean water treatments, suggesting that these modifications had persisted for 7 months (>15 generations). We also identified modifications that were only present in the populations that had switched to clean water, indicating a long-term legacy of pollutant exposure distinct from the persistent effects. Pollutant-induced differential methylation tended to occur at sites that were highly methylated in controls. Modifications that were observed in both continually and switched treatments were highly methylated in controls and showed reduced methylation in the treatments. On the other hand, modifications found just in the switched treatment tended to have lower levels of methylation in the controls and showed increase methylation in the switched treatment. In a second experiment, we confirmed that sublethal doses of the same pollutants generate effects on life histories for at least three generations following the removal of the pollutant. Our results demonstrate that even low doses of pollutants can induce transgenerational epigenetic effects that are stably transmitted over many generations. Persistent effects are likely to influence phenotypic development, which could contribute to the rapid adaptation, or extinction, of populations confronted by anthropogenic stressorsThis work was funded by the Natural Environment Research Council, UK as a standard grant (NE/I024437/1) awarded to SJP, DB, and SP, and a highlight grant (NE/N016017/1) awarded to SJP and SPWith the institutional support of the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000928-S)Peer reviewedSociety for the Study of EvolutionNatural Environment Research Council (UK)Agencia Estatal de Investigación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/269575reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésHarney, Ewan; Paterson, Steve; Collin, Hélène; Chan, Brian H.K.; Bennett, Daimark; Plaistow, Stewart J.; 2022; Pollution induces epigenetic effects that are stably transmitted across multiple generations [Dataset]; Dryad; https://doi.org/10.5061/dryad.h9w0vt4k9Harney, Ewan; Paterson, Steve; Collin, Hélène; Chan, Brian H.K; Bennett, Daimark; Plaistow, Stewart J.; 2022; Pollution induces epigenetic effects that are stably transmitted across multiple generations [Software]; Zenodo; Version 1; https://doi.org/10.5281/zenodo.5926900https://doi.org/10.1002/evl3.273Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2695752026-05-22T06:33:51Z
score 15,812429

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