Genomic Instability and Epigenetic Changes during Aging

Aging is considered the deterioration of physiological functions along with an increased mortality rate. This scientific review focuses on the central importance of genomic instability during the aging process, encompassing a range of cellular and molecular changes that occur with advancing age. In...

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Detalles Bibliográficos
Autores: López-Gil, Lucía, Pascual-Ahuir, Amparo, Proft, Markus
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/336468
Acceso en línea:http://hdl.handle.net/10261/336468
Access Level:acceso abierto
Palabra clave:Aging
Genomic instability
Epigenetics
Chromatin
Histones
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spelling Genomic Instability and Epigenetic Changes during AgingLópez-Gil, LucíaPascual-Ahuir, AmparoProft, MarkusAgingGenomic instabilityEpigeneticsChromatinHistonesAging is considered the deterioration of physiological functions along with an increased mortality rate. This scientific review focuses on the central importance of genomic instability during the aging process, encompassing a range of cellular and molecular changes that occur with advancing age. In particular, this revision addresses the genetic and epigenetic alterations that contribute to genomic instability, such as telomere shortening, DNA damage accumulation, and decreased DNA repair capacity. Furthermore, the review explores the epigenetic changes that occur with aging, including modifications to histones, DNA methylation patterns, and the role of non-coding RNAs. Finally, the review discusses the organization of chromatin and its contribution to genomic instability, including heterochromatin loss, chromatin remodeling, and changes in nucleosome and histone abundance. In conclusion, this review highlights the fundamental role that genomic instability plays in the aging process and underscores the need for continued research into these complex biological mechanismsResearch of the authors was funded by grants from Ministerio de Ciencia, Innovación y Universidades PID2019-104214RB-I00 (A.P.-A., M.P.) and Agencia Valenciana de la Innovación INNEST/2021/266 (A.P.-A.)Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Agència Valenciana de la InnovacióProft, Markus [0000-0002-6788-5830]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2023202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/336468reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104214RB-I00https://doi.org/10.3390/ijms241814279Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3364682026-05-22T06:33:51Z
dc.title.none.fl_str_mv Genomic Instability and Epigenetic Changes during Aging
title Genomic Instability and Epigenetic Changes during Aging
spellingShingle Genomic Instability and Epigenetic Changes during Aging
López-Gil, Lucía
Aging
Genomic instability
Epigenetics
Chromatin
Histones
title_short Genomic Instability and Epigenetic Changes during Aging
title_full Genomic Instability and Epigenetic Changes during Aging
title_fullStr Genomic Instability and Epigenetic Changes during Aging
title_full_unstemmed Genomic Instability and Epigenetic Changes during Aging
title_sort Genomic Instability and Epigenetic Changes during Aging
dc.creator.none.fl_str_mv López-Gil, Lucía
Pascual-Ahuir, Amparo
Proft, Markus
author López-Gil, Lucía
author_facet López-Gil, Lucía
Pascual-Ahuir, Amparo
Proft, Markus
author_role author
author2 Pascual-Ahuir, Amparo
Proft, Markus
author2_role author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Agència Valenciana de la Innovació
Proft, Markus [0000-0002-6788-5830]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Aging
Genomic instability
Epigenetics
Chromatin
Histones
topic Aging
Genomic instability
Epigenetics
Chromatin
Histones
description Aging is considered the deterioration of physiological functions along with an increased mortality rate. This scientific review focuses on the central importance of genomic instability during the aging process, encompassing a range of cellular and molecular changes that occur with advancing age. In particular, this revision addresses the genetic and epigenetic alterations that contribute to genomic instability, such as telomere shortening, DNA damage accumulation, and decreased DNA repair capacity. Furthermore, the review explores the epigenetic changes that occur with aging, including modifications to histones, DNA methylation patterns, and the role of non-coding RNAs. Finally, the review discusses the organization of chromatin and its contribution to genomic instability, including heterochromatin loss, chromatin remodeling, and changes in nucleosome and histone abundance. In conclusion, this review highlights the fundamental role that genomic instability plays in the aging process and underscores the need for continued research into these complex biological mechanisms
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/336468
url http://hdl.handle.net/10261/336468
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104214RB-I00
https://doi.org/10.3390/ijms241814279
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
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instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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