Social avoidance and altered hypothalamic-pituitary-adrenal axis in a mouse model of anxious depression: the role of LPA1 receptor

Anxious depression is a prevalent disease with devastating consequences. Despite the lack of knowledge about the neurobiological basis of this subtype of depression, recently our group has identified a relationship between the LPA1 receptor, one of the six characterized G protein-coupled receptors (...

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Autores: Moreno-Fernández, R. D., Sampedro Piquero, Patricia, Gómez-Salas, F. J., Nieto-Quero, A., Estivill-Torrús, G., Rodríguez de Fonseca, F., Santín, L. J., Pedraza, C.
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/711814
Acceso en línea:http://hdl.handle.net/10486/711814
https://dx.doi.org/10.1016/j.bbr.2023.114681
Access Level:acceso abierto
Palabra clave:corticosterone
depression
dexamethasone
HPA-axis
LPA receptor 1
social preference
Psicología
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spelling Social avoidance and altered hypothalamic-pituitary-adrenal axis in a mouse model of anxious depression: the role of LPA1 receptorMoreno-Fernández, R. D.Sampedro Piquero, PatriciaGómez-Salas, F. J.Nieto-Quero, A.Estivill-Torrús, G.Rodríguez de Fonseca, F.Santín, L. J.Pedraza, C.corticosteronedepressiondexamethasoneHPA-axisLPA receptor 1social preferencePsicologíaAnxious depression is a prevalent disease with devastating consequences. Despite the lack of knowledge about the neurobiological basis of this subtype of depression, recently our group has identified a relationship between the LPA1 receptor, one of the six characterized G protein-coupled receptors (LPA1–6) for lysophosphatidic acid, with a mixed depressive-anxiety phenotype. Dysfunctional social behaviors, which have been related to increased activation of the hypothalamus-pituitary-adrenal (HPA) axis, are key symptoms of depression and are even more prominent in patients with comorbid anxiety and depressive disorders. Social behavior and HPA functioning were assessed in animals lacking the LPA1 receptor. For these purposes, we first examined social behaviors in wild-type and LPA1 receptor-null mice. In addition, a dexamethasone (DEX) suppression test was carried out. maLPA1-null mice exhibited social avoidance, a blunted response to DEX administration and an impaired circadian rhythm of corticosterone levels, which are features that are consistently dysregulated in many mental illnesses including anxious depression. Here, we have strengthened the previous experimental evidence for maLPA1-null mice to represent a good animal model of anxious depression, providing an opportunity to explore new therapeutic targets for the treatment of mood disorders, particularly this subtype of depressionElsevierDepartamento de Psicología Biológica y de la SaludFacultad de Psicología20232023-10-18research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/711814https://dx.doi.org/10.1016/j.bbr.2023.114681reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7118142026-06-23T12:46:27Z
dc.title.none.fl_str_mv Social avoidance and altered hypothalamic-pituitary-adrenal axis in a mouse model of anxious depression: the role of LPA1 receptor
title Social avoidance and altered hypothalamic-pituitary-adrenal axis in a mouse model of anxious depression: the role of LPA1 receptor
spellingShingle Social avoidance and altered hypothalamic-pituitary-adrenal axis in a mouse model of anxious depression: the role of LPA1 receptor
Moreno-Fernández, R. D.
corticosterone
depression
dexamethasone
HPA-axis
LPA receptor 1
social preference
Psicología
title_short Social avoidance and altered hypothalamic-pituitary-adrenal axis in a mouse model of anxious depression: the role of LPA1 receptor
title_full Social avoidance and altered hypothalamic-pituitary-adrenal axis in a mouse model of anxious depression: the role of LPA1 receptor
title_fullStr Social avoidance and altered hypothalamic-pituitary-adrenal axis in a mouse model of anxious depression: the role of LPA1 receptor
title_full_unstemmed Social avoidance and altered hypothalamic-pituitary-adrenal axis in a mouse model of anxious depression: the role of LPA1 receptor
title_sort Social avoidance and altered hypothalamic-pituitary-adrenal axis in a mouse model of anxious depression: the role of LPA1 receptor
dc.creator.none.fl_str_mv Moreno-Fernández, R. D.
Sampedro Piquero, Patricia
Gómez-Salas, F. J.
Nieto-Quero, A.
Estivill-Torrús, G.
Rodríguez de Fonseca, F.
Santín, L. J.
Pedraza, C.
author Moreno-Fernández, R. D.
author_facet Moreno-Fernández, R. D.
Sampedro Piquero, Patricia
Gómez-Salas, F. J.
Nieto-Quero, A.
Estivill-Torrús, G.
Rodríguez de Fonseca, F.
Santín, L. J.
Pedraza, C.
author_role author
author2 Sampedro Piquero, Patricia
Gómez-Salas, F. J.
Nieto-Quero, A.
Estivill-Torrús, G.
Rodríguez de Fonseca, F.
Santín, L. J.
Pedraza, C.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Psicología Biológica y de la Salud
Facultad de Psicología
dc.subject.none.fl_str_mv corticosterone
depression
dexamethasone
HPA-axis
LPA receptor 1
social preference
Psicología
topic corticosterone
depression
dexamethasone
HPA-axis
LPA receptor 1
social preference
Psicología
description Anxious depression is a prevalent disease with devastating consequences. Despite the lack of knowledge about the neurobiological basis of this subtype of depression, recently our group has identified a relationship between the LPA1 receptor, one of the six characterized G protein-coupled receptors (LPA1–6) for lysophosphatidic acid, with a mixed depressive-anxiety phenotype. Dysfunctional social behaviors, which have been related to increased activation of the hypothalamus-pituitary-adrenal (HPA) axis, are key symptoms of depression and are even more prominent in patients with comorbid anxiety and depressive disorders. Social behavior and HPA functioning were assessed in animals lacking the LPA1 receptor. For these purposes, we first examined social behaviors in wild-type and LPA1 receptor-null mice. In addition, a dexamethasone (DEX) suppression test was carried out. maLPA1-null mice exhibited social avoidance, a blunted response to DEX administration and an impaired circadian rhythm of corticosterone levels, which are features that are consistently dysregulated in many mental illnesses including anxious depression. Here, we have strengthened the previous experimental evidence for maLPA1-null mice to represent a good animal model of anxious depression, providing an opportunity to explore new therapeutic targets for the treatment of mood disorders, particularly this subtype of depression
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-10-18
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/711814
https://dx.doi.org/10.1016/j.bbr.2023.114681
url http://hdl.handle.net/10486/711814
https://dx.doi.org/10.1016/j.bbr.2023.114681
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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