Intracellular signals activated by canonical wnt ligands independent of GSK3 inhibition and β-catenin stabilization

In contrast to non-canonical ligands, canonical Wnts promote the stabilization of β-catenin, which is a prerequisite for formation of the TCF4/β-catenin transcriptional complex and activation of its target genes. This pathway is initiated by binding of Wnt ligands to the Frizzled/LRP5/6 receptor com...

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Detalhes bibliográficos
Autores: García de Herreros, Antonio, Duñach, Mireia
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/42948
Acesso em linha:http://hdl.handle.net/10230/42948
http://dx.doi.org/10.3390/cells8101148
Access Level:acceso abierto
Palavra-chave:Frizzled
LRP5/6
ROR2
STAT3
Wnt signaling
YAP/TAZ
β-catenin
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spelling Intracellular signals activated by canonical wnt ligands independent of GSK3 inhibition and β-catenin stabilizationGarcía de Herreros, AntonioDuñach, MireiaFrizzledLRP5/6ROR2STAT3Wnt signalingYAP/TAZβ-cateninIn contrast to non-canonical ligands, canonical Wnts promote the stabilization of β-catenin, which is a prerequisite for formation of the TCF4/β-catenin transcriptional complex and activation of its target genes. This pathway is initiated by binding of Wnt ligands to the Frizzled/LRP5/6 receptor complex, and it increases the half-life of β-catenin by precluding the phosphorylation of β-catenin by GSK3 and its binding to the βTrCP1 ubiquitin ligase. Other intercellular signals are also activated by Wnt ligands that do not inhibit GSK3 and increase β-catenin protein but that either facilitate β-catenin transcriptional activity or stimulate other transcriptional factors that cooperate with it. In this review, we describe the layers of complexity of these signals and discuss their crosstalk with β-catenin in activation of transcriptional targets.This research was funded by grants from the Ministerio de Ciencia, Innovación y Universidades (RTI2018-099719-B-100 cofunded by Fondos Feder, SAF2013-40922-R1 and SAF2016-76461-R). Support from ICREA Academia is also appreciated.MDPI201920192019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/42948http://dx.doi.org/10.3390/cells8101148reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésCells. 2019 Sep 25;8(10):1148info:eu-repo/grantAgreement/ES/1PE/SAF2013-40922-R1info:eu-repo/grantAgreement/ES/1PE/SAF2016-76461-R© García de Herreros A, Duñach M. by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/429482026-05-29T05:05:01Z
dc.title.none.fl_str_mv Intracellular signals activated by canonical wnt ligands independent of GSK3 inhibition and β-catenin stabilization
title Intracellular signals activated by canonical wnt ligands independent of GSK3 inhibition and β-catenin stabilization
spellingShingle Intracellular signals activated by canonical wnt ligands independent of GSK3 inhibition and β-catenin stabilization
García de Herreros, Antonio
Frizzled
LRP5/6
ROR2
STAT3
Wnt signaling
YAP/TAZ
β-catenin
title_short Intracellular signals activated by canonical wnt ligands independent of GSK3 inhibition and β-catenin stabilization
title_full Intracellular signals activated by canonical wnt ligands independent of GSK3 inhibition and β-catenin stabilization
title_fullStr Intracellular signals activated by canonical wnt ligands independent of GSK3 inhibition and β-catenin stabilization
title_full_unstemmed Intracellular signals activated by canonical wnt ligands independent of GSK3 inhibition and β-catenin stabilization
title_sort Intracellular signals activated by canonical wnt ligands independent of GSK3 inhibition and β-catenin stabilization
dc.creator.none.fl_str_mv García de Herreros, Antonio
Duñach, Mireia
author García de Herreros, Antonio
author_facet García de Herreros, Antonio
Duñach, Mireia
author_role author
author2 Duñach, Mireia
author2_role author
dc.subject.none.fl_str_mv Frizzled
LRP5/6
ROR2
STAT3
Wnt signaling
YAP/TAZ
β-catenin
topic Frizzled
LRP5/6
ROR2
STAT3
Wnt signaling
YAP/TAZ
β-catenin
description In contrast to non-canonical ligands, canonical Wnts promote the stabilization of β-catenin, which is a prerequisite for formation of the TCF4/β-catenin transcriptional complex and activation of its target genes. This pathway is initiated by binding of Wnt ligands to the Frizzled/LRP5/6 receptor complex, and it increases the half-life of β-catenin by precluding the phosphorylation of β-catenin by GSK3 and its binding to the βTrCP1 ubiquitin ligase. Other intercellular signals are also activated by Wnt ligands that do not inhibit GSK3 and increase β-catenin protein but that either facilitate β-catenin transcriptional activity or stimulate other transcriptional factors that cooperate with it. In this review, we describe the layers of complexity of these signals and discuss their crosstalk with β-catenin in activation of transcriptional targets.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/42948
http://dx.doi.org/10.3390/cells8101148
url http://hdl.handle.net/10230/42948
http://dx.doi.org/10.3390/cells8101148
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Cells. 2019 Sep 25;8(10):1148
info:eu-repo/grantAgreement/ES/1PE/SAF2013-40922-R1
info:eu-repo/grantAgreement/ES/1PE/SAF2016-76461-R
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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