Universal administration of nirsevimab in infants: an analysis of hospitalisations and paediatric intensive care unit admissions for RSV-associated lower respiratory tract infections

Producción Científica

Bibliographic Details
Authors: Bermudez Barrezueta, Lorena Concepción, Matías del Pozo, Vanesa, Marugán de Miguelsanz, José Manuel, Infante López, Elena, Uribe Reina, Pilar, Romero del Hombrebueno, Yara, Morales Moreno, Antonio Jesús, Rojo Rello, Silvia, Eiros Bouza, José María, Pino Vázquez, María de la Asunción
Format: article
Status:Published version
Publication Date:2025
Country:España
Institution:Universidad de Valladolid
Repository:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/75939
Online Access:https://doi.org/10.1007/s00431-025-06125-5
https://uvadoc.uva.es/handle/10324/75939
Access Level:Open access
Keyword:Lower respiratory tract infection
Nirsevimab
Paediatric intensive care unit
Respiratory syncytial virus
3201.10 Pediatría
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oai_identifier_str oai:uvadoc.uva.es:10324/75939
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spelling Universal administration of nirsevimab in infants: an analysis of hospitalisations and paediatric intensive care unit admissions for RSV-associated lower respiratory tract infectionsBermudez Barrezueta, Lorena ConcepciónMatías del Pozo, VanesaMarugán de Miguelsanz, José ManuelInfante López, ElenaUribe Reina, PilarRomero del Hombrebueno, YaraMorales Moreno, Antonio JesúsRojo Rello, SilviaEiros Bouza, José MaríaPino Vázquez, María de la AsunciónLower respiratory tract infectionNirsevimabPaediatric intensive care unitRespiratory syncytial virus3201.10 PediatríaProducción CientíficaThe aim of this study was to assess the impact of universal nirsevimab administration on hospitalisations and paediatric intensive care unit (PICU) admissions due to lower respiratory tract infection associated with respiratory syncytial virus (RSV-LRTI). An observational study was conducted at a tertiary hospital in Spain to compare the frequency and charac- teristics of children under five years of age hospitalised for RSV-LRTI between October 2023 and March 2024 (nirsevimab period), with the data from two prepandemic COVID- 19 seasons (2018–2019 and 2019–2020) and one postpandemic season (2022–2023). A total of 311 patients were included in the study. During the nirsevimab period, a decrease in the number of children hospitalised for RSV-LRTI was observed, particularly for children under six months of age. Compared with the pre- pandemic period, there was an 83.3% decrease in hospitalisations and a 73.3% reduction in PICU admissions in this age group. Similarly, compared with the postpandemic period, there was a 90.8% reduction in hospitalisations and an 87.9% reduction in PICU admissions. Furthermore, the median age was greater (15.6 months; IQR 11.1–27.3) than it was in the prepandemic period (4 months; IQR 1.6–8.9) and postpandemic period (3.4 months; IQR 1.5–10.6) (p < 0.001). Moreover, the length of hospital stay during the nirsevimab period (4 days; IQR 3–6) was shorter than that observed during the prepandemic period (6 days; IQR 4–9) and the postpandemic period (5 days; IQR 3–8) (p = 0.003). Conclusions: Following the introduction of universal immunoprophylaxis with nirsevimab, notable reductions in hospi- talisations and PICU admissions due to RSV-LRTI were observed among young infants. This resulted in a shift in the age profile and a shorter length of hospital stay.Open access funding provided by FEDER European Funds and the Junta De Castilla y León under the Research and Innovation Strategy for Smart Specialization (RIS3) of Castilla y León 2021-2027.Springer2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.1007/s00431-025-06125-5https://uvadoc.uva.es/handle/10324/75939reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidIngléshttps://link.springer.com/article/10.1007/s00431-025-06125-5info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:uvadoc.uva.es:10324/759392026-06-13T12:44:47Z
dc.title.none.fl_str_mv Universal administration of nirsevimab in infants: an analysis of hospitalisations and paediatric intensive care unit admissions for RSV-associated lower respiratory tract infections
title Universal administration of nirsevimab in infants: an analysis of hospitalisations and paediatric intensive care unit admissions for RSV-associated lower respiratory tract infections
spellingShingle Universal administration of nirsevimab in infants: an analysis of hospitalisations and paediatric intensive care unit admissions for RSV-associated lower respiratory tract infections
Bermudez Barrezueta, Lorena Concepción
Lower respiratory tract infection
Nirsevimab
Paediatric intensive care unit
Respiratory syncytial virus
3201.10 Pediatría
title_short Universal administration of nirsevimab in infants: an analysis of hospitalisations and paediatric intensive care unit admissions for RSV-associated lower respiratory tract infections
title_full Universal administration of nirsevimab in infants: an analysis of hospitalisations and paediatric intensive care unit admissions for RSV-associated lower respiratory tract infections
title_fullStr Universal administration of nirsevimab in infants: an analysis of hospitalisations and paediatric intensive care unit admissions for RSV-associated lower respiratory tract infections
title_full_unstemmed Universal administration of nirsevimab in infants: an analysis of hospitalisations and paediatric intensive care unit admissions for RSV-associated lower respiratory tract infections
title_sort Universal administration of nirsevimab in infants: an analysis of hospitalisations and paediatric intensive care unit admissions for RSV-associated lower respiratory tract infections
dc.creator.none.fl_str_mv Bermudez Barrezueta, Lorena Concepción
Matías del Pozo, Vanesa
Marugán de Miguelsanz, José Manuel
Infante López, Elena
Uribe Reina, Pilar
Romero del Hombrebueno, Yara
Morales Moreno, Antonio Jesús
Rojo Rello, Silvia
Eiros Bouza, José María
Pino Vázquez, María de la Asunción
author Bermudez Barrezueta, Lorena Concepción
author_facet Bermudez Barrezueta, Lorena Concepción
Matías del Pozo, Vanesa
Marugán de Miguelsanz, José Manuel
Infante López, Elena
Uribe Reina, Pilar
Romero del Hombrebueno, Yara
Morales Moreno, Antonio Jesús
Rojo Rello, Silvia
Eiros Bouza, José María
Pino Vázquez, María de la Asunción
author_role author
author2 Matías del Pozo, Vanesa
Marugán de Miguelsanz, José Manuel
Infante López, Elena
Uribe Reina, Pilar
Romero del Hombrebueno, Yara
Morales Moreno, Antonio Jesús
Rojo Rello, Silvia
Eiros Bouza, José María
Pino Vázquez, María de la Asunción
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Lower respiratory tract infection
Nirsevimab
Paediatric intensive care unit
Respiratory syncytial virus
3201.10 Pediatría
topic Lower respiratory tract infection
Nirsevimab
Paediatric intensive care unit
Respiratory syncytial virus
3201.10 Pediatría
description Producción Científica
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1007/s00431-025-06125-5
https://uvadoc.uva.es/handle/10324/75939
url https://doi.org/10.1007/s00431-025-06125-5
https://uvadoc.uva.es/handle/10324/75939
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://link.springer.com/article/10.1007/s00431-025-06125-5
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869417259872550912
score 15.811543

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