Mechanical ventilation in patients with cardiogenic pulmonary edema

Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality. Patients from the LUNG SAFE cohort, a multicenter prospective cohor...

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Authors: Amado-Rodríguez, Laura|||0000-0002-8793-0213, Rodríguez-Garcia, Raquel, Albaiceta, Guillermo M.|||0000-0002-9276-3253, Pham, Tài|||0000-0002-4373-0711, Fan, Eddy, Madotto, Fabiana|||0000-0002-8829-9160, Laffey, John|||0000-0002-1246-9573, Pesenti, A., Brochard, Laurent, Esteban, Andrés|||0000-0002-0146-3328, Gattinoni, Luciano, Van Haren, Frank, Larsson, Anders, McAuley, Daniel F., Ranieri, Marco, Rubenfeld, Gordon, Taylor Thompson, B., Wrigge, Hermann, Slutsky, Arthur S., Rios, Fernando|||0000-0002-5419-7254, Sottiaux, Thierry, Depuydt, Pieter, Lora, Fredy S., Azevedo, Luciano Cesar, Bugedo, Guillermo, Qiu, Haibo, González, Marcos, Silesky, Juan, Cerny, Vladimir, Nielsen, Jonas, Jibaja, Manuel, Matamis, Dimitrios, Ranero, Jorge Luis, Amin, Pravin, Hashemian, S.M., Clarkson, Kevin, Kurahashi, Kyyoyasu, Villagomez, Asisclo, Zeggwagh, Amine Ali, Heunks, L.M., Laake, Jon Henrik|||0000-0001-6157-5359, Palo, Jose Emmanuel, do Vale Fernandes, Antero, Sandesc, Dorel, Arabi, Yaasen, Bumbasierevic, Vesna, Nin, Nicolas, Lorente, Jose A., Piquilloud, Lise|||0000-0002-4226-8772, Abroug, Fekri|||0000-0002-5626-5329, McNamee, Lia, Hurtado, Javier, Bajwa, Ed, Démpaire, Gabriel, Sula, Hektor, Nunci, Lordian, Cani, Alma, Zazu, Alan, Dellera, Christian, Insaurralde, Carolina S., Las Lomas, Sanatorio, Isidro, San, Alejandro, Risso V., Daldin, Julio, Vinzio, Mauricio, Fernandez, Ruben O., Cardonnet, Luis P., Bettini, Lisandro R., Bisso, Mariano Carboni, Osman, Emilio M., Setten, Mariano G., Lovazzano, Pablo, Alvarez, Javier, Villar, Veronica, Pozo, Norberto C., Grubissich, Nicolas, Plotnikow, Gustavo A.|||0000-0003-0115-870X, Vasquez, Daniela N., Ilutovich, Santiago, Tiribelli, Norberto, Chena, Ariel, Pellegrini, Carlos A., Saenz, María G., Estenssoro, Elisa, Brizuela, Matias, Gianinetto, Hernan, Gomez, Pablo E., Cerrato, Valeria I., Bezzi, Marco G., Borello, Silvina A., Loiacono, Flavia A., Fernandez, Adriana M., Knowles, Serena|||0000-0002-5028-3825, Reynolds, Claire, Inskip, Deborah M., Miller, Jennene J., Kong, Jing, Whitehead, Christina, Bihari, Shailesh|||0000-0001-7553-8620, Seven, Aylin, Krstevski, Amanda, Rodgers, Helen J., Millar, Rebecca T., McKenna, Toni E., Bailey, Irene M., Hanlon, Gabrielle C., Aneman, Anders, Lynch, Joan M., Azad, Raman, Neal, John, Woods, Paul W., Roberts, Brigit L., Kol, Mark R., Wong, Helen S., Riss, Katharina C., Staudinger, Thomas, Wittebole, Xavier, Berghe, Caroline, Bulpa, Pierre A., Dive, Alain M., Verstraete, Rik, Lebbinck, Herve, Vermassen, Joris, Meersseman, Philippe, Ceunen, Helga, Rosa, Jonas I., Beraldo, Daniel O., Piras, Claudio, Rampinelli, Adenilton M., Nassar Jr, Antonio P., Mataloun, Sergio, Moock, Marcelo, Thompson, Marlus M., Gonçalves, Claudio H., Antônio, Ana Carolina P., Ascoli, Aline, Biondi, Rodrigo S., Fontenele, Danielle C., Nobrega, Danielle, Sales, Vanessa M., BinHJAbul Wahab, Ahmad Yazid, Ismail, Maizatul, Shindhe, Suresh, Beloncle, François, Davies, Kyle G., Cirone, Rob, Manoharan, Venika, Ismail, Mehvish, Goligher, Ewan C., Jassal, Mandeeep, Nishikawa, Erin, Javeed, Areej, Curley, Gerard|||0000-0003-0271-195X, Rittayamai, Nuttapol|||0000-0001-6844-6314, Parotto, Matteo|||0000-0003-1165-4264, Ferguson, Niall D., Mehta, Sangeeta|||0000-0002-7073-4769, Knoll, Jenny, Pronovost, Antoine, Canestrini, Sergio, Bruhn, Alejandro R., Garcia, Patricio H., Aliaga, Felipe A., Farías, Pamela A., Yumha, Jacob S., Ortiz, Claudia A., Salas, Javier E., Saez, Alejandro A., Vega, Luis D., Labarca, Eduardo F., Martinez, Felipe T., Carreño, Nicolás G., Lora, Pilar, Liu, Haitao, Liu, Ling, Tang, Rui, Luo, Xiaoming, An, Youzhong, Zhao, Huiying, Gao, Yan, Zhai, Zhe, Ye, Zheng L., Wang, Wei|||0000-0002-5750-6980, Li, Wenwen, Li, Qingdong, Zheng, Ruiqiang, Yu, Wenkui, Shen, Juanhong, Li, Xinyu, Yu, Tao, Lu, Weihua, Wu, Ya Q., Huang, Xiao B., He, Zhenyang, Lu, Yuanhua, Han, Hui, Zhang, Fan, Sun, Renhua, Wang, Hua X., Qin, Shu H., Zhu, Bao H., Zhao, Jun, Liu, Jian|||0000-0003-4199-1296, Li, Bin, Liu, Jing L., Zhou, Fa C., Li, Q.J., Zhang, X.Y., Li-Xin, Z., Xin-Hua, Q., Jiang, L., Gao, Y.N., Zhao, X.Y., Li, Y.Y., Li, X.L., Wang, C., Yao, Qingchun, Yu, R., Chen, K., Shao, H., Qin, B., Huang, Q.Q., Zhu, W.H., Hang, A.Y., Hua, M.X., Li, Yuda|||0000-0001-8031-6555, Xu, Y., Di, Y.D., Ling, L.L., Qin, T.H., Wang, S.H., Qin, J., Han, Y., Zhou, S., Vargas, M.P., Jimenez, J.I.S., Rojas, M.A.G., SolisQuesada, J.E., Ramirez-Alfaro, Christian M., Máca, Jan|||0000-0002-9771-0468, Sklienka, P., Gjedsted, Jakob, Christiansen, A., Nielsen, J., Villamagua, B.G., Llano, Iguel, Burtin, P., Buzancais, G., Beuret, P., Pelletier, N., Mortaza, S., Mercat, A., Chelly, J., Jochmans, Sébasien, Terzi, N., Daubin, C., Carteaux, G., de Prost, N., Chiche, Jean-Daniel, Daviaud, F., Fartoukh, M., Barberet, G., Biehler, J., Dellamonica, J., Doyen, D., Arnal, Jean-Michel, Briquet, A., Hraiech, S., Papazian, L., Follin, A., Roux, D., Messika, J., Kalaitzis, E., Dangers, L., Combes, A., Béduneau, G., Carpentier, D., Zogheib, Elie|||0000-0002-1112-1807, Dupont, H., Ricome, S., Santoli, F.L., Besset, S.L., Michel, P., Gelée, B., Danin, P.E., Goubaux, B., Crova, P.J., Phan, N.T., Berkelmans, F., Badie, Julio C., Tapponnier, R., Gally, J., Khebbeb, S., Herbrecht, J.E., Schneider, F., Declercq, P.L.M., Rigaud, J.P., Duranteau, J., Harrois, A., Chabanne, R., Marin, J., Bigot, C., Thibault, S., Ghazi, M., Boukhazna, M., Zein, Salem Ould, Richecoeur, J.R., Combaux, D.M., Grelon, F., Le Moal, C., Sauvadet, E.P., Robine, A., Lemiale, V., Reuter, D., Dres, M., Demoule, A., Goldgran-Toledano, D., Baboi, Loredana, Guérin, C., Lohner, R., Kraßler, J., Schäfer, S., Zacharowski, Kai|||0000-0002-0212-9110, Meybohm, P., Reske, A.W., Simon, P., Hopf, H.B.F., Schuetz, M., Baltus, T., Papanikolaou, M.N., Papavasilopoulou, T.G., Zacharas, Giannis A., Ourailogloy, Vasilis, Mouloudi, E.K., Massa, E.V., Nagy, E.O., Stamou, E.E., Kiourtzieva, E.V., Oikonomou, M.A., Avila, L.E., Cortez, C.A., Citalán, J.E., Jog, S.A., Sable, S.D., Shah, B., Gurjar, Mohan|||0000-0002-8489-0324, Baronia, A.K., Memon, M., Muthuchellappan, R., Ramesh, V.J., Shenoy, A., Unnikrishnan, R., Dixit, S.B., Rhayakar, R.V., Ramakrishnan, N., Bhardwaj, V.K., Mahto, H.L., Sagar, S.V., Palaniswamy, V., Ganesan, D., Jamaati, H., Heidari, F., Meaney, E.A., Nichol, A., Knapman, K.M., O'Croinin, D., Dunne, E.S., Breen, D.M., Jaafar, Rola F., Dwyer, Rory, Amir, F., Ajetunmobi, Olaitan O., O'Muircheartaigh, A.C., Black, C.S., Treanor, N., Collins, D.V., Altaf, W., Zani, Gianluca|||0000-0002-7982-8913, Fusari, M., Spadaro, S., Volta, Carlo Alberto, Graziani, R., Brunettini, B., Palmese, S., Formenti, P., Umbrello, M., Lombardo, A., Pecci, E., Botteri, M., Savioli, M., Protti, A., Mattei, A., Schiavoni, L., Tinnirello, A., Todeschini, M., Giarratano, Antonino, Cortegiani, Andrea|||0000-0003-1416-9993, Sher, S., Rossi, A., Antonelli, M.M., Montini, L.M., Casalena, P., Scafetti, S., Panarello, G., Occhipinti, G., Patroniti, N., Pozzi, M., Biscione, R.R., Poli, M.M., Raimondi, F., Albiero, Daniela, Crapelli, Giulia, Beck, E., Pota, V., Schiavone, V., Molin, Alexandre, Tarantino, F., Monti, G., Frati, E., Mirabella, L., Cinnella, G.|||0000-0001-9864-2893, Fossali, Tommaso, Colombo, Riccardo, Terragni, P.|||0000-0002-4274-7546, Pattarino, Ilaria, Mojoli, Francesco|||0000-0002-6031-6336, Braschi, Antonio, Borotto, Erika E., Cracchiolo, Andrea Neville, Palma, Daniela Maria, Raponi, Francesco, Foti, Giuseppe, Vascotto, Ettore R., Coppadoro, Andrea|||0000-0003-1759-4071, Brazzi, Luca|||0000-0001-7059-0622, Floris, Leda, Iotti, Giorgio Antonio|||0000-0003-0305-8921, Venti, Aaron, Yamaguchi, Osamu, Takagi, Shunsuke, Maeyama, Hiroki N., Watanabe, Eizo, Yamaji, Yoshihiro, Shimizu, Kazuyoshi, Shiozaki, Kyoko, Futami, Satoru, Ryosuke, Sekine, Saito, Koji, Kameyama, Yoshinobu, Ueno, Keiko, Izawa, Masayo, Okuda, Nao, Suzuki, Hiroyuki, Harasawa, Tomofumi, Nasu, Michitaka, Takada, Tadaaki, Ito, Fumihito, Nunomiya, Shin, 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Rinia, M., Raaijmakers, M., Van Wezel, H.M., Heines, S.J., Strauch, U., Buise, M.P., Simonis, F.D., Schultz, M. J., Goodson, Jennifer C., Browne, T.S., Navarra, Leanlove, Hunt, A., Hutchison, R.A., Bailey, M.B., Newby, L., McArthur, C., Kalkoff, M., Mcleod, A., Casement, J., Hacking, D.J., Andersen, Finn H.|||0000-0003-3775-7325, Dolva, M.S., Barratt-Due, Andreas, Noremark, K.A.L., Søreide, E., Sjøbø, B., Guttormsen, A.B., LeonYoshido, H.H., Aguilar, R.Z., Oscanoa, F.A.M., Alisasis, A.U., Robles, J.B., Pasanting-Lim, R.A.B., Tan, B.C., Andruszkiewicz, P., Jakubowska, K., Coxo, C.M., Alvarez, A.M., Oliveira, B.S., Montanha, G.M., Barros, N.C., Pereira, C.S., Messias, A.M., Monteiro, J.M., Araujo, A.M., Catorze, N.T., Marum, S.M., Bouw, Maria José, Gomes, Rui M., Brito, Vânia A., Castro, Sílvia, Berger-Estilita, Joana|||0000-0002-8695-4264, Barros, Filipa M., Serra, Isabel M., Martinho, Aurelia M., Tomescu, Dana|||0000-0001-9673-5754, Marcu, Alexandra, Bedreag, Ovidiu Horea, Papurica, Marius, Corneci, Dan E., Negoita, Silvius Ioan, Grigoryev, Evgeny|||0000-0001-8370-3083, Gritsan, Alexey|||0000-0002-0500-2887, Gazenkampf, Andrey A., Almekhlafi, Ghaleb A.|||0000-0002-0323-7025, Albarrak, Mohamad M., Mustafa, Ghanem M., Maghrabi, Khalid A., Salahuddin, Nawal, Aisa, Tharwat Mahmoud, AlJabbary, Ahmed S., Tabhan, Edgardo, Trinidad, Olivia A., Al-Dorzi, Hasan M.|||0000-0002-3772-8949, Bumbasirevic, Vesna D., Jovanovic, Bojan M., Bolon, Stefan, Smith, Oliver I., Mancebo Cortes, Jordi|||0000-0003-3308-5410, Aguirre-Bermeo, Hernan|||0000-0001-7205-7020, López-Delgado, Juan Carlos|||0000-0003-3324-1129, Esteve, Francisco, Rialp, Gemma|||0000-0003-3614-3639, Forteza, Catalina, De Haro, Candelària, Artigas Raventós, Antoni|||0000-0002-8029-1017, De Cima-Iglesias, Sara, Seoane-Quiroga, Leticia, Ceniceros-Barros, Alexandra, RuizAguilar, Antonio L., Claraco-Vega, Luis Manuel, Soler, Juan Alfonso, del CarmenLorente, Maria, Hermosa, Cecilia, Gordo Vidal, Federico|||0000-0001-9605-1918, PrietoGonzález, Miryam, López-Messa, Juan B., Perez, Manuel P., Perez, Cesar P., Allue, Raquel Montorio, RocheCampo, Ferran, Ibañez-Santacruz, Marcos, Temprano, Susana, Pintado, María Consuelo, de Pablo Sánchez, Raúl|||0000-0003-0542-7882, Gómez, Pilar Ricart Aroa, Ruiz, Silvia Rodriguez, Iglesias Moles, Silvia, Jurado, Mª Teresa, Arizmendi, Alfons, Piacentini, Enrique A., Franco, Nieves, Honrubia, Teresa, Cheng, Meisy Perez, Losada, Elena Pérez, Blanco, Javier I., Yuste, Luís J., Carbayo-Gorriz, Cecilia, Cazorla-Barranquero, Francisca G., García Alonso, Francisco Javier, Alda, Rosa Sebastián, Algaba, Ángela, Navarro, Gonzalo, Cereijo, Enrique, Diaz-Rodriguez, Esther, Marcos, Diego Pastor, Montero, Laura Alvarez, Herrera Para, Luis|||0000-0002-0353-0141, Sanchez, Roberto Jimenez, Navalpotro, Miguel Angel Blasco, Abad, Ricardo Diaz, Montiel González, Raquel|||0000-0001-9553-1549, Toribio, Dácil Parrilla, González Castro, Alejandro|||0000-0001-5927-336X, Artiga, María José Domínguez, Peñuelas, Oscar|||0000-0003-1484-3933, Roser, Tomas P., Olga, Moreno F., Gallego Curto, Elena, Sánchez, Rocio Manzano, Vallverdú, Immaculada, Elisabet, Garcia M., Claverias Cabrera, Laura|||0000-0002-7170-3788, Magret, Mónica, Pellicer, Ana M., Rodriguez, Lucía L., Sánchez-Ballesteros, Jesus S., González-Salamanca, Ángela, Jimenez, Antonio G., Huerta, Francisco P., Díaz, Juan Carlos J.Sotillo, López, Esther Bermejo, Llinares Moya, David D., Alfonso, Alec A. Tallet, Palazon Sanchez, Eugenio Luis, Palazon Sanchez, Cesar, Sánchez, I. Rafael, Corcoles Gonzalez, Virgilio, Recio, Noelia N., Adamsson, Richard O., Rylander, Christian C., Holzgraefe, Bernhard|||0000-0002-5654-7764, Broman, Lars Mikael|||0000-0003-4124-4581, Wessbergh, Joanna, Persson, Linnea, Schiöler, Fredrik, Kedelv, Hans, Tibblin, A.O., Appelberg, Henrik, Hedlund, Lars, Helleberg, Johan, Eriksson, Karin E., Glietsch, Rita, Larsson, Niklas, Nygren, Ingela, Nunes, Silvia L., Morin, Anna Karin, Kander, Thomas|||0000-0002-5404-2981, Adolfsson, Anne, Zender, Hervé Olivier, Leemann-Refondini, Corinne, Elatrous, Souheil, Bouchoucha, Slaheddine, Chouchene, Imed, Ouanes, Islem, Souissi, Asma Ben|||0000-0001-7772-0573, Kamoun, Salma, Demirkiran, Oktay, Aker, Mustafa, Erbabacan, Emre, Ceylan, Ilkay|||0000-0003-3306-3107, Girgin, Nermin Kelebek, Özçelik, Menekşe, Unal, Necmettin|||0000-0002-9440-7893, Meço, Başak Ceyda Orbey, Akyol, Onat|||0000-0003-1316-7160, Derman, Süleyman S., Kennedy, Barry, Parhar, Ken Kuljit Singh, Srinivasa, L., McNamee, Latha, Hopkins, Phil Anthony, Mellis, Clare, Kakar, Vivek|||0000-0001-6353-3283, Hadfield, Daniel J., Vercueil, Andre E., Bhowmick, Kaushik, Humphreys, Sally K., Ferguson, Andrew J., Mckee, Raymond, Raj, Ashok Sundai, Fawkes, Danielle A., Watt, Philip, Twohey, Linda C., Jha, Rajeev R., Thomas, Matt, Morton, Alex, Kadaba, Varsha R., Smith, Mark J., Hormis, Anil P., Kannan, Santhana G., Namih, Miriam, Reschreiter, Henrik Peer, Camsooksai, Julie, Kumar, Alek, Rugonfalvi, Szabolcs, Nutt, Christopher L., Oneill, Orla, Seasman, Colette, Dempsey, Ged A., Scott, Christopher J., Ellis, Helen E., Mckechnie, Stuart R., Hutton, Paula J., Di Tomasso, Nora|||0000-0001-5706-8928, Vitale, Michela N., Griffin, Ruth O., Dean, Michael N., Cranshaw, Julius H., Willett, Emma L., Ioannou, Nicholas, Gillis, Sarah, Csábi, Péter, Macfadyen, Rosaleen, Dawson, Heidi, Preez, Pieter D., Williams, Alexandra J., Boyd, Owen F., de Gordoa, Laura Ortiz Ruiz, Bramall, Jon, Symmonds, Sophie, Chau, Simon K., Wenham, Tim N., Szakmany, Tamas|||0000-0003-3632-8844, Toth-Tarsoly, Piroska, McCalman, Katie H., Alexander, Peter D.G., Stephenson, Lorraine, Collyer, Thomas C., Chapman, Rhiannon, Cooper, Raphael, Allan, Russell Morton, Sim, Malcolm A. B., Wrathall, David Wayne, Irvine, Donald A., Zantua, Charing Kim S., Adams, John C., Burtenshaw, Andrew J., Sellors, Gareth P., Welters, Ingeborg|||0000-0002-3408-8798, Williams, Karen E., Hessell, Robert J., Oldroyd, Matthew G., Battle, Ceri|||0000-0002-7503-1931, Pillai, Suresh G., Kajtor, Istvan, Sivashanmugavel, Mageswaran, Okane, Sinead C., Donnelly, Adrian, Frigyik, Aniko D., Careless, Jon P., May, Martin M., Stewart, Richard, Trinder, Thomas John, Hagan, Samantha J., Cole, Jade M., MacFie, Caroline C., Dowling, Anna T., Hurtado, J., Nin, N., Nuñez, Edgardo, Pittini, Gustavo, Rodriguez, Ruben, Imperio, María C., Santos, Cristina|||0000-0002-7014-8014, França, Ana G., Ebeid, Alejandro, Deicas, Alberto, Serra, Carolina, Uppalapati, Aditya, Kamel, Ghassan, BannerGoodspeed, Valerie M., Beitler, Jeremy R., Mukkera, Satyanarayana Reddy, Kulkarni, Shreedhar|||0000-0002-9521-8461, Shinn, John O., Gomaa, Dina, Tainter, Christopher R., Lee, Jarone, Mesar, Tomaz, Yeatts, Dale J., Warren, Jessica, Lanspa, Michael J., Miller, Russell R., Grissom, Colin K., Brown, Samuel M., Bauer, Philippe R., Gosselin, Ryan J., Kitch, Barrett T., Cohen, Jason E., Beegle, Scott H., Choudry, Shazia, Gueret, Renaud M., Tulaimat, Aiman, Stigler, William Steve, Batra, Hitesh, Huff, Nidhi G., Lamb, Keith D., Oetting, Trevor W., Mohr, Nicholas|||0000-0003-0497-5828, Judy, Claine, Saito, Shigeki, Kheir, Fayez M., Kheir, F., Schlichting, Adam B., Delsing, Angela S., Crouch, Daniel R., Elmasri, Mary, Crouch, D.R., Ismail, Dina, Dreyer, Kyle R., Blakeman, Thomas Christopher, Gomaa, D., Baro, Rebecca M., Hou, Peter Chuanyi, Seethala, Raghu R., Aisiku, Imoigele P., Henderson, Galen V., Frendl, György Y., Hou, Sen-Kuang, Owens, Robert Llewellyn, Schomer, Ashley M.
Format: article
Publication Date:2022
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:290514
Online Access:https://ddd.uab.cat/record/290514
https://dx.doi.org/urn:doi:10.1186/s40560-022-00648-x
Access Level:Open access
Keyword:Cardiogenic pulmonary edema
Driving pressure
Mechanical ventilation
Ventilator-induced lung injury
Description
Summary:Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality. Patients from the LUNG SAFE cohort, a multicenter prospective cohort study of patients undergoing mechanical ventilation, were studied. Relationships between ventilatory parameters and outcomes (ICU discharge/hospital mortality) were assessed using latent mixture analysis and a marginal structural model. From 4499 patients, 391 meeting CPE criteria (median age 70 [interquartile range 59-78], 40% female) were included. ICU and hospital mortality were 34% and 40%, respectively. ICU survivors were younger (67 [57-77] vs 74 [64-80] years, p < 0.001) and had lower driving (12 [8-16] vs 15 [11-17] cmHO, p < 0.001), plateau (20 [15-23] vs 22 [19-26] cmHO, p < 0.001) and peak (21 [17-27] vs 26 [20-32] cmHO, p < 0.001) pressures. Latent mixture analysis of patients receiving invasive mechanical ventilation on ICU day 1 revealed a subgroup ventilated with high pressures with lower probability of being discharged alive from the ICU (hazard ratio [HR] 0.79 [95% confidence interval 0.60-1.05], p = 0.103) and increased hospital mortality (HR 1.65 [1.16-2.36], p = 0.005). In a marginal structural model, driving pressures in the first week (HR 1.12 [1.06-1.18], p < 0.001) and tidal volume after day 7 (HR 0.69 [0.52-0.93], p = 0.015) were related to survival. Higher airway pressures in invasively ventilated patients with CPE are related to mortality. These patients may be exposed to an increased risk of ventilator-induced lung injury. Trial registration Clinicaltrials.gov NCT02010073.