Graded changes in local functional connectivity of the cerebral cortex in young people with depression

Background: Major depressive disorder (MDD) is marked by significant changes to the local synchrony of spontaneous neural activity across various brain regions. However, many methods for assessing this local connectivity use fixed or arbitrary neighborhood sizes, resulting in a decreased capacity to...

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Autores: Jamieson, Alec J., Davey, Christopher G., Pujol Nuez, Jesús, Blanco Hinojo, Laura, 1981-, Harrison, Ben J.
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2025
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:dnet:recercat____::ac4f13e970f6c0bee5c14bca2a1bebc2
Acesso em linha:https://hdl.handle.net/10230/73108
http://dx.doi.org/10.1017/S0033291725000510
Access Level:Acceso aberto
Palavra-chave:Major depressive disorder
Adolescent
Local functional connectivity
Resting-state
Young adult
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spelling Graded changes in local functional connectivity of the cerebral cortex in young people with depressionJamieson, Alec J.Davey, Christopher G.Pujol Nuez, JesúsBlanco Hinojo, Laura, 1981-Harrison, Ben J.Major depressive disorderAdolescentLocal functional connectivityResting-stateYoung adultBackground: Major depressive disorder (MDD) is marked by significant changes to the local synchrony of spontaneous neural activity across various brain regions. However, many methods for assessing this local connectivity use fixed or arbitrary neighborhood sizes, resulting in a decreased capacity to capture smooth changes to the spatial gradient of local correlations. A newly developed method sensitive to classical anatomo-functional boundaries, Iso-Distant Average Correlation (IDAC), was therefore used to examine depression associated alterations to the local functional connectivity of the brain. Method: One-hundred and forty-seven adolescents and young adults with MDD and 94 healthy controls underwent a resting-state functional magnetic resonance imaging (fMRI) scan. Whole-brain functional connectivity maps of intracortical neural activity within iso-distant local areas (5-10, 15-20, and 25-30 mm) were generated to characterize local fMRI signal similarities. Results: Across all spatial distances, MDD participants demonstrated greater local functional connectivity of the bilateral posterior hippocampus, retrosplenial cortex, dorsal insula, fusiform gyrus, and supplementary motor area. Local connectivity alterations in short and medium distances (5-10 and 15-20 mm) in the mid insula cortex were additionally associated with expressive suppression use, independent of depressive symptom severity. Conclusions: Our study identified increased synchrony of the neural activity in several regions commonly implicated in the neurobiology of depression. These effects were relatively consistent across the three distances examined. Longitudinal investigation of this altered local connectivity will clarify whether these differences are also found in other age groups and if this relationship is modified by increased disease chronicity.Cambridge University Press2026202620252026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/10230/73108http://dx.doi.org/10.1017/S0033291725000510https://hdl.handle.net/10230/73108reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésPsychological Medicine. 2025 Mar 17:55:e88© The Author(s), 2025. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.http://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessoai:dnet:recercat____::ac4f13e970f6c0bee5c14bca2a1bebc22026-05-29T05:05:01Z
dc.title.none.fl_str_mv Graded changes in local functional connectivity of the cerebral cortex in young people with depression
title Graded changes in local functional connectivity of the cerebral cortex in young people with depression
spellingShingle Graded changes in local functional connectivity of the cerebral cortex in young people with depression
Jamieson, Alec J.
Major depressive disorder
Adolescent
Local functional connectivity
Resting-state
Young adult
title_short Graded changes in local functional connectivity of the cerebral cortex in young people with depression
title_full Graded changes in local functional connectivity of the cerebral cortex in young people with depression
title_fullStr Graded changes in local functional connectivity of the cerebral cortex in young people with depression
title_full_unstemmed Graded changes in local functional connectivity of the cerebral cortex in young people with depression
title_sort Graded changes in local functional connectivity of the cerebral cortex in young people with depression
dc.creator.none.fl_str_mv Jamieson, Alec J.
Davey, Christopher G.
Pujol Nuez, Jesús
Blanco Hinojo, Laura, 1981-
Harrison, Ben J.
author Jamieson, Alec J.
author_facet Jamieson, Alec J.
Davey, Christopher G.
Pujol Nuez, Jesús
Blanco Hinojo, Laura, 1981-
Harrison, Ben J.
author_role author
author2 Davey, Christopher G.
Pujol Nuez, Jesús
Blanco Hinojo, Laura, 1981-
Harrison, Ben J.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Major depressive disorder
Adolescent
Local functional connectivity
Resting-state
Young adult
topic Major depressive disorder
Adolescent
Local functional connectivity
Resting-state
Young adult
description Background: Major depressive disorder (MDD) is marked by significant changes to the local synchrony of spontaneous neural activity across various brain regions. However, many methods for assessing this local connectivity use fixed or arbitrary neighborhood sizes, resulting in a decreased capacity to capture smooth changes to the spatial gradient of local correlations. A newly developed method sensitive to classical anatomo-functional boundaries, Iso-Distant Average Correlation (IDAC), was therefore used to examine depression associated alterations to the local functional connectivity of the brain. Method: One-hundred and forty-seven adolescents and young adults with MDD and 94 healthy controls underwent a resting-state functional magnetic resonance imaging (fMRI) scan. Whole-brain functional connectivity maps of intracortical neural activity within iso-distant local areas (5-10, 15-20, and 25-30 mm) were generated to characterize local fMRI signal similarities. Results: Across all spatial distances, MDD participants demonstrated greater local functional connectivity of the bilateral posterior hippocampus, retrosplenial cortex, dorsal insula, fusiform gyrus, and supplementary motor area. Local connectivity alterations in short and medium distances (5-10 and 15-20 mm) in the mid insula cortex were additionally associated with expressive suppression use, independent of depressive symptom severity. Conclusions: Our study identified increased synchrony of the neural activity in several regions commonly implicated in the neurobiology of depression. These effects were relatively consistent across the three distances examined. Longitudinal investigation of this altered local connectivity will clarify whether these differences are also found in other age groups and if this relationship is modified by increased disease chronicity.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/10230/73108
http://dx.doi.org/10.1017/S0033291725000510
https://hdl.handle.net/10230/73108
url https://hdl.handle.net/10230/73108
http://dx.doi.org/10.1017/S0033291725000510
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Psychological Medicine. 2025 Mar 17:55:e88
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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